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Aliases for PCLAF Gene
Aliases for PCLAF Gene
External Ids for PCLAF Gene
- HGNC: 28961
- Entrez Gene: 9768
- Ensembl: ENSG00000166803
- OMIM: 610696
- UniProtKB: Q15004
Previous HGNC Symbols for PCLAF Gene
- KIAA0101
Previous GeneCards Identifiers for PCLAF Gene
- GC15M064366
- GC15M064369
- GC15M064395
- GC15M064549
Summaries for PCLAF Gene
GeneCards Summary for PCLAF Gene
PCLAF (PCNA Clamp Associated Factor) is a Protein Coding gene. Diseases associated with PCLAF include Thyroid Carcinoma and Heart Conduction Disease. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and DNA Double-Strand Break Repair. An important paralog of this gene is ENSG00000259316.
UniProtKB/Swiss-Prot Summary for PCLAF Gene
-
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Additional gene information for PCLAF Gene
- HGNC(28961)
- Entrez Gene(9768)
- Ensembl(ENSG00000166803)
- OMIM(610696)
- UniProtKB(Q15004)
- Open Targets Platform(ENSG00000166803)
- Search for PCLAF at DataMed
- Search for PCLAF at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCLAF Gene
Genomics for PCLAF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PCLAF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PCLAF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCLAF
Genomic Locations for PCLAF Gene
Genomic Locations for PCLAF Gene
- chr15:64,364,304-64,387,687
- (GRCh38/hg38)
- Size:
- 23,384 bases
- Orientation:
- Minus strand
- chr15:64,657,193-64,679,886
- (GRCh37/hg19)
- Size:
- 22,694 bases
- Orientation:
- Minus strand
Genomic View for PCLAF Gene
Genes around PCLAF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by HGNC
- 15q22.31 by Entrez Gene
- 15q22.31 by Ensembl
PCLAF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCLAF Gene
Proteins for PCLAF Gene
-
Protein details for PCLAF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15004-PAF15_HUMAN
- Recommended name:
- PCNA-associated factor
- Protein Accession:
- Q15004
- A6NNU5
- A8K3Y3
- G9G694
- G9G696
Protein attributes for PCLAF Gene
- Size:
- 111 amino acids
- Molecular mass:
- 11986 Da
- Quaternary structure:
-
- Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.
- SequenceCaution:
-
- Sequence=BAA03491.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer.
Three dimensional structures from OCA and Proteopedia for PCLAF Gene
Post-translational modifications for PCLAF Gene
- Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.
-
Ubiquitination at Lys15 and Lys63
- NX_Q15004 (NX_Q15004-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PCLAF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PCNA-Associated Factor Antibody
- Creative Diagnostics Anti-KIAA0101 monoclonal antibody, clone 4D22-2G22
- Creative Biolabs Mouse Anti-PCLAF Recombinant Antibody (3C11-1F11)
-
Custom Antibody ServicesOriGene Antibodies for PCLAF
- Novus Biologicals Antibodies for PCLAF
-
Abcam antibodies for PCLAF
- Invitrogen Antibodies for PCLAF (AFLGC-PCLAF)
- Sino Biological Antibodies for PCLAF
Protein Products
-
OriGene Purified Proteins for PCLAF
- Search Origene for MassSpec and Protein Over-expression Lysates for PCLAF
- Origene Custom Protein Services for PCLAF
- Sino Biological Recombinant Proteins for PCLAF
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PCLAF
-
Abcam proteins for PCLAF
No data available for DME Specific Peptides for PCLAF Gene
Domains & Families for PCLAF Gene
Gene Families for PCLAF Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PCLAF Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCLAF Gene
- GenScript: Design optimal peptide antigens:
-
- p15PAF (PAF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15004UniProtKB/Swiss-Prot:
PAF15_HUMAN :- The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
- Domain:
-
- The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
- The KEN box is required for the association with the APC/C complex.
- The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
- The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrate's degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (PubMed:21700221).
Function for PCLAF Gene
Molecular function for PCLAF Gene
- UniProtKB/Swiss-Prot Function:
- PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
- UniProtKB/Swiss-Prot Induction:
- By UV irradiation. By ATF3 in response to UV-stress.
Phenotypes From GWAS Catalog for PCLAF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IBA,IDA | 23000965 |
| GO:0005515 | protein binding | IPI | 21628590 |
Phenotypes for PCLAF Gene
- MGI mutant phenotypes for PCLAF:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PCLAF:
Animal Models for PCLAF Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PCLAF - Select products 50% OFF >
- * PCLAF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PCLAF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCLAF
miRNA for PCLAF Gene
- miRTarBase miRNAs that target PCLAF
-
- hsa-miR-193b-3p (MIRT016453)
- hsa-miR-124-3p (MIRT022855)
- hsa-miR-122-5p (MIRT023371)
- hsa-miR-181a-5p (MIRT025163)
- hsa-miR-26b-5p (MIRT029795)
- hsa-miR-1227-3p (MIRT072611)
- hsa-miR-466 (MIRT506876)
- hsa-miR-539-5p (MIRT506877)
- hsa-miR-4643 (MIRT506878)
- hsa-miR-4789-3p (MIRT506879)
- hsa-miR-519c-3p (MIRT506880)
- hsa-miR-519b-3p (MIRT506881)
- hsa-miR-519a-3p (MIRT506882)
- hsa-miR-93-5p (MIRT506883)
- hsa-miR-526b-3p (MIRT506884)
- hsa-miR-519d-3p (MIRT506885)
- hsa-miR-20b-5p (MIRT506886)
- hsa-miR-20a-5p (MIRT506887)
- hsa-miR-17-5p (MIRT506888)
- hsa-miR-106b-5p (MIRT506889)
- hsa-miR-106a-5p (MIRT506890)
- hsa-miR-548t-5p (MIRT506891)
- hsa-miR-548az-5p (MIRT506892)
- mmu-miR-539-3p (MIRT592375)
- mmu-miR-381-3p (MIRT592376)
- mmu-miR-3082-5p (MIRT600015)
- mmu-miR-759 (MIRT600016)
- mmu-miR-804 (MIRT600017)
- mmu-miR-1195 (MIRT600018)
- mmu-miR-3089-5p (MIRT600019)
- mmu-miR-706 (MIRT600020)
- mmu-miR-665-3p (MIRT600021)
- hsa-miR-616-5p (MIRT638548)
- hsa-miR-373-5p (MIRT638549)
- hsa-miR-371b-5p (MIRT638550)
- hsa-miR-6747-3p (MIRT638551)
- hsa-miR-6727-3p (MIRT638552)
- hsa-miR-4722-3p (MIRT638553)
- hsa-miR-4705 (MIRT638554)
- hsa-miR-4698 (MIRT638555)
- hsa-miR-8063 (MIRT638556)
- hsa-miR-3156-5p (MIRT638557)
- hsa-miR-551b-5p (MIRT638558)
- hsa-miR-335-3p (MIRT642579)
- hsa-miR-4715-3p (MIRT642580)
- hsa-miR-664b-3p (MIRT642581)
- hsa-miR-579-3p (MIRT642582)
- hsa-miR-5696 (MIRT642583)
- hsa-miR-7151-3p (MIRT642584)
- hsa-miR-5095 (MIRT642585)
- hsa-miR-661 (MIRT642586)
- hsa-miR-3116 (MIRT642587)
- hsa-miR-1254 (MIRT642588)
- hsa-miR-149-5p (MIRT642589)
- hsa-miR-153-5p (MIRT642590)
- hsa-miR-1250-3p (MIRT642591)
- hsa-miR-6504-3p (MIRT642592)
- hsa-miR-455-5p (MIRT642593)
- hsa-miR-4438 (MIRT642594)
- hsa-miR-7703 (MIRT715861)
- hsa-miR-6807-5p (MIRT715862)
- hsa-miR-4252 (MIRT715863)
- hsa-miR-4793-3p (MIRT715864)
- hsa-miR-1273g-3p (MIRT715865)
- hsa-miR-3934-5p (MIRT715866)
- hsa-miR-512-5p (MIRT715867)
- hsa-miR-552-3p (MIRT715868)
- hsa-miR-24-3p (MIRT720517)
- hsa-miR-4284 (MIRT720518)
- hsa-miR-6872-3p (MIRT720519)
- hsa-miR-183-5p (MIRT733502)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCLAF
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCLAF
Clone Products
- Applied Biological Materials (abm): Clones for PCLAF - Select products 50% OFF >
- * PCLAF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PCLAF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
Cell Line Products
-
Horizon Cell Lines for PCLAF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCLAF Gene
Localization for PCLAF Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCLAF Gene
- Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites (PubMed:21628590). Colocalizes with centrosomes in perinuclear region (PubMed:21673012).
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| mitochondrion | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Centrosome (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 21628590 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA,IDA | 21673012 |
Pathways & Interactions for PCLAF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for PCLAF Gene
4 Reactome pathways for PCLAF Gene
Interacting Proteins for PCLAF Gene
Selected Interacting proteins:
Q15004-PAF15_HUMAN
ENSP00000300035
for PCLAF Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PCLAF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006260 | DNA replication | IDA | 23000965 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 21628590 |
| GO:0007098 | centrosome cycle | IMP | 21673012 |
| GO:0009411 | response to UV | IDA | 23000965 |
Transcripts for PCLAF Gene
mRNA/cDNA for PCLAF Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300035 2132 nts (view in UCSC)
- ENST00000380258 911 nts (view in UCSC)
- ENST00000558008 766 nts (view in UCSC)
- ENST00000558043 689 nts (view in UCSC)
- ENST00000558250 807 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PCLAF - Select products 50% OFF >
- * PCLAF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PCLAF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCLAF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCLAF
- Browse OriGene Inhibitory RNA Products For PCLAF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCLAF
Clone Products
- Applied Biological Materials (abm): Clones for PCLAF - Select products 50% OFF >
- * PCLAF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PCLAF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
Relevant External Links for PCLAF Gene
- GeneLoc Exon Structure for
- PCLAF
Expression for PCLAF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCLAF
mRNA Expression by UniProt/SwissProt for PCLAF Gene:
Q15004-PAF15_HUMAN
Tissue specificity:
Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.
Evidence on tissue expression from TISSUES for PCLAF Gene
- Nervous system(4.9)
- Bone marrow(4.6)
- Adrenal gland(4.2)
- Blood(3.9)
- Liver(3)
- Intestine(2.8)
- Lung(2.8)
- Heart(2.7)
- Lymph node(2.6)
- Skin(2.6)
- Spleen(2.4)
- Muscle(2.3)
- Stomach(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for PCLAF
-
OriGene qPCR primer pairs and template standards for PCLAF
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCLAF Gene
Orthologs for PCLAF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KIAA0101 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PAF 31 |
|
OneToOne | |
| KIAA0101 30 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Ns5atp9 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | 2810417H13Rik 30 31 |
|
OneToOne | |
| Pclaf 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | KIAA0101 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KIAA0101 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KIAA0101 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KIAA0101 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kiaa0101 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100333229 30 |
|
||
| Dr.12145 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8724 30 |
|
- Species where no ortholog for PCLAF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PCLAF Gene
- ENSEMBL:
- Gene Tree for PCLAF (if available)
- TreeFam:
- Gene Tree for PCLAF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PCLAF: view image
Paralogs for PCLAF Gene
Paralogs for PCLAF Gene
Variants for PCLAF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCLAF Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11554313 | - | p.Glu79Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1224n106 | CNV | deletion | 24896259 |
| esv1497681 | CNV | deletion | 17803354 |
| esv2319425 | CNV | deletion | 18987734 |
| esv2675981 | CNV | deletion | 23128226 |
| esv2749782 | CNV | deletion | 23290073 |
| esv2749783 | CNV | deletion | 23290073 |
| esv3337124 | CNV | insertion | 20981092 |
| esv3552562 | CNV | deletion | 23714750 |
| esv3636733 | CNV | loss | 21293372 |
| esv3892709 | CNV | loss | 25118596 |
| esv4243 | CNV | loss | 18987735 |
| nsv94581 | CNV | deletion | 16902084 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PCLAF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PCLAF
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCLAF Gene
Disorders for PCLAF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thyroid carcinoma |
|
|
| heart conduction disease |
|
|
| posterolateral myocardial infarction |
|
|
| cardiac tamponade |
|
|
| anaerobic pneumonia |
|
|
Search PCLAF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PCLAF
No data available for UniProtKB/Swiss-Prot and Genatlas for PCLAF Gene
Publications for PCLAF Gene
- p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. (PMID: 11313979) Yu P … Luo Y (Oncogene 2001) 2 3 4 23
- The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. (PMID: 16288740) Simpson F … Wicking C (Experimental cell research 2006) 2 3 4
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen LK … Choudhary C (Nature cell biology 2012) 3 4
- KIAA0101 interacts with BRCA1 and regulates centrosome number. (PMID: 21673012) Kais Z … Parvin JD (Molecular cancer research : MCR 2011) 3 4
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. (PMID: 21628590) Emanuele MJ … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
ExternalLinks
Products for PCLAF Gene
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- Abcam proteins for PCLAF
- Find your target
- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for PCLAF (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PCLAF (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PCLAF (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PCLAF CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PCLAF
- antibodies-online: Show 13 available KIAA0101 Antibodies ranked by validation data
- Compare Top KIAA0101 Antibodies
- antibodies-online: Show 22 available KIAA0101 Elisa Kits ranked by validation data
- Compare Top KIAA0101 Elisa Kits
- antibodies-online: Show 8 available KIAA0101 Proteins ranked by validation data
- Compare Top KIAA0101 Proteins
- Horizon Cell Lines for PCLAF
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCLAF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PCLAF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCLAF
Sources for PCLAF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB