Aliases for PCLAF Gene
Aliases for PCLAF Gene
External Ids for PCLAF Gene
- HGNC: 28961
- Entrez Gene: 9768
- Ensembl: ENSG00000166803
- OMIM: 610696
- UniProtKB: Q15004
Previous HGNC Symbols for PCLAF Gene
- KIAA0101
Summaries for PCLAF Gene
GeneCards Summary for PCLAF Gene
PCLAF (PCNA Clamp Associated Factor) is a Protein Coding gene. Diseases associated with PCLAF include Posterolateral Myocardial Infarction and Hepatitis C Virus. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and DNA Double-Strand Break Repair. An important paralog of this gene is ENSG00000259316.
UniProtKB/Swiss-Prot for PCLAF Gene
-
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCLAF Gene
Genomics for PCLAF Gene
GeneHancer (GH) Regulatory Elements for PCLAF Gene
Promoters and enhancers for PCLAF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PCLAF on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PCLAF Gene
Genomic Locations for PCLAF Gene
- chr15:64,364,311-64,387,687
- (GRCh38/hg38)
- Size:
- 23,377 bases
- Orientation:
- Minus strand
- chr15:64,657,193-64,679,886
- (GRCh37/hg19)
- Size:
- 22,694 bases
- Orientation:
- Minus strand
Genomic View for PCLAF Gene
Genes around PCLAF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
- 15q22.31 by Ensembl
PCLAF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCLAF Gene
Proteins for PCLAF Gene
-
Protein details for PCLAF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15004-PAF15_HUMAN
- Recommended name:
- PCNA-associated factor
- Protein Accession:
- Q15004
- A6NNU5
- A8K3Y3
- G9G694
- G9G696
Protein attributes for PCLAF Gene
- Size:
- 111 amino acids
- Molecular mass:
- 11986 Da
- Quaternary structure:
-
- Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.
- Miscellaneous:
-
- Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer.
- SequenceCaution:
-
- Sequence=BAA03491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for PCLAF Gene
- Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PCLAF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PCLAF
- Novus Biologicals Antibodies for PCLAF
-
Abcam antibodies for PCLAF
- Invitrogen Antibodies for PCLAF
- Search GeneTex for Antibodies for PCLAF
- Sino Biological Antibodies for PCLAF
Protein Products
-
OriGene Purified Proteins for PCLAF
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- ProSpec Recombinant Proteins for PCLAF
- Search GeneTex for Proteins for PCLAF
-
Abcam proteins for PCLAF
Assay Products
No data available for DME Specific Peptides for PCLAF Gene
Domains & Families for PCLAF Gene
Gene Families for PCLAF Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PCLAF Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15004UniProtKB/Swiss-Prot:
PAF15_HUMAN :- The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
- Domain:
-
- The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).
- The KEN box is required for the association with the APC/C complex.
- The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
- The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrates degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (PubMed:21700221).
Function for PCLAF Gene
Molecular function for PCLAF Gene
- UniProtKB/Swiss-Prot Function:
- PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
- UniProtKB/Swiss-Prot Induction:
- By UV irradiation. By ATF3 in response to UV-stress.
Phenotypes From GWAS Catalog for PCLAF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 23000965 |
| GO:0005515 | protein binding | IPI | 21628590 |
Phenotypes for PCLAF Gene
- MGI mutant phenotypes for PCLAF:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PCLAF:
Animal Models for PCLAF Gene
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PCLAF
-
CRISPR Products
-
OriGene CRISPR knockouts for PCLAF
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-
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- GenScript: Design CRISPR guide RNA sequences for PCLAF
miRNA for PCLAF Gene
- miRTarBase miRNAs that target PCLAF
-
- hsa-mir-193b-3p (MIRT016453)
- hsa-mir-124-3p (MIRT022855)
- hsa-mir-122-5p (MIRT023371)
- hsa-mir-181a-5p (MIRT025163)
- hsa-mir-26b-5p (MIRT029795)
- hsa-mir-1227-3p (MIRT072611)
- hsa-mir-466 (MIRT506876)
- hsa-mir-539-5p (MIRT506877)
- hsa-mir-4643 (MIRT506878)
- hsa-mir-4789-3p (MIRT506879)
- hsa-mir-519c-3p (MIRT506880)
- hsa-mir-519b-3p (MIRT506881)
- hsa-mir-519a-3p (MIRT506882)
- hsa-mir-93-5p (MIRT506883)
- hsa-mir-526b-3p (MIRT506884)
- hsa-mir-519d-3p (MIRT506885)
- hsa-mir-20b-5p (MIRT506886)
- hsa-mir-20a-5p (MIRT506887)
- hsa-mir-17-5p (MIRT506888)
- hsa-mir-106b-5p (MIRT506889)
- hsa-mir-106a-5p (MIRT506890)
- hsa-mir-548t-5p (MIRT506891)
- hsa-mir-548az-5p (MIRT506892)
- hsa-mir-616-5p (MIRT638548)
- hsa-mir-373-5p (MIRT638549)
- hsa-mir-371b-5p (MIRT638550)
- hsa-mir-6747-3p (MIRT638551)
- hsa-mir-6727-3p (MIRT638552)
- hsa-mir-4722-3p (MIRT638553)
- hsa-mir-4705 (MIRT638554)
- hsa-mir-4698 (MIRT638555)
- hsa-mir-8063 (MIRT638556)
- hsa-mir-3156-5p (MIRT638557)
- hsa-mir-551b-5p (MIRT638558)
- hsa-mir-335-3p (MIRT642579)
- hsa-mir-4715-3p (MIRT642580)
- hsa-mir-664b-3p (MIRT642581)
- hsa-mir-579-3p (MIRT642582)
- hsa-mir-5696 (MIRT642583)
- hsa-mir-7151-3p (MIRT642584)
- hsa-mir-5095 (MIRT642585)
- hsa-mir-661 (MIRT642586)
- hsa-mir-3116 (MIRT642587)
- hsa-mir-1254 (MIRT642588)
- hsa-mir-149-5p (MIRT642589)
- hsa-mir-153-5p (MIRT642590)
- hsa-mir-1250-3p (MIRT642591)
- hsa-mir-6504-3p (MIRT642592)
- hsa-mir-455-5p (MIRT642593)
- hsa-mir-4438 (MIRT642594)
- hsa-mir-7703 (MIRT715861)
- hsa-mir-6807-5p (MIRT715862)
- hsa-mir-4252 (MIRT715863)
- hsa-mir-4793-3p (MIRT715864)
- hsa-mir-1273g-3p (MIRT715865)
- hsa-mir-3934-5p (MIRT715866)
- hsa-mir-512-5p (MIRT715867)
- hsa-mir-552-3p (MIRT715868)
- hsa-mir-24-3p (MIRT720517)
- hsa-mir-4284 (MIRT720518)
- hsa-mir-6872-3p (MIRT720519)
- hsa-mir-183-5p (MIRT733502)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCLAF
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Clone Products
- Sino Biological Human cDNA Clone for PCLAF
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
- genomics-online: cdna clones - Search results for available KIAA0101 gene related products
- orf clones - Search results for available KIAA0101 gene related products
- Applied Biological Materials Clones for PCLAF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PCLAF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCLAF Gene
Localization for PCLAF Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCLAF Gene
- Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites (PubMed:21628590). Colocalizes with centrosomes in perinuclear region (PubMed:21673012).
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| lysosome | 2 |
| endoplasmic reticulum | 1 |
- Centrosome (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 21628590 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA,IDA | 21673012 |
Pathways & Interactions for PCLAF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for PCLAF Gene
4 Reactome pathways for PCLAF Gene
Interacting Proteins for PCLAF Gene
Selected Interacting proteins:
ENSP00000300035
Q15004-PAF15_HUMAN
for PCLAF Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for PCLAF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006260 | DNA replication | IDA | 23000965 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA,IDA | 21628590 |
| GO:0007098 | centrosome cycle | IMP | 21673012 |
| GO:0009411 | response to UV | IDA | 23000965 |
Transcripts for PCLAF Gene
mRNA/cDNA for PCLAF Gene
- (2) REFSEQ mRNAs :
- (712) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000300035 2194 bps (uc002ank.5)
- ENST00000380258 911 bps (uc002anl.5)
- ENST00000559519 749 bps (uc059kfq.1)
- ENST00000558008 766 bps (uc059kfr.1)
- ENST00000558043 689 bps (uc059kfs.1)
CRISPR Products
-
OriGene CRISPR knockouts for PCLAF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCLAF
- genomics-online: gRNA clones - Search results for available KIAA0101 gene related products
- Applied Biological Materials CRISPR for PCLAF
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PCLAF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCLAF
- Browse OriGene Inhibitory RNA Products For PCLAF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCLAF
- genomics-online: shRNA clones - Search results for available KIAA0101 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PCLAF
- VectorBuilder custom plasmid, inducible vectors for PCLAF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCLAF
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
- genomics-online: cdna clones - Search results for available KIAA0101 gene related products
- orf clones - Search results for available KIAA0101 gene related products
- Applied Biological Materials Clones for PCLAF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PCLAF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
NURSA nuclear receptor signaling pathways regulating expression of PCLAF Gene:
PCLAFmRNA Expression by UniProt/SwissProt for PCLAF Gene:
Q15004-PAF15_HUMAN
Tissue specificity:
Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.
Evidence on tissue expression from TISSUES for PCLAF Gene
- Nervous system(4.9)
- Bone marrow(4.3)
- Adrenal gland(4)
- Blood(3.8)
- Lung(2.8)
- Intestine(2.5)
- Liver(2.5)
- Heart(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for PCLAF
-
OriGene qPCR primer pairs for PCLAF
- genomics-online: primer clones - Search results for available KIAA0101 gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCLAF Gene
Orthologs for PCLAF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIAA0101 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PAF 34 |
|
OneToOne | |
| KIAA0101 33 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Ns5atp9 33 |
|
||
| mouse (Mus musculus) |
Mammalia | 2810417H13Rik 34 33 |
|
OneToOne | |
| Pclaf 16 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | KIAA0101 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KIAA0101 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KIAA0101 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KIAA0101 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kiaa0101 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100333229 33 |
|
||
| Dr.12145 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8724 33 |
|
- Species where no ortholog for PCLAF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PCLAF Gene
- ENSEMBL:
- Gene Tree for PCLAF (if available)
- TreeFam:
- Gene Tree for PCLAF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PCLAF: view image
Paralogs for PCLAF Gene
Paralogs for PCLAF Gene
Variants for PCLAF Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029826 | -- | 64,383,845(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000047199 | -- | 64,377,908(-) | C/G/T | intron_variant | |
| rs1000052251 | -- | 64,379,350(-) | G/T | intron_variant | |
| rs1000130516 | -- | 64,366,703(-) | T/C | intron_variant | |
| rs1000220255 | -- | 64,389,473(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1224n106 | CNV | deletion | 24896259 |
| esv1497681 | CNV | deletion | 17803354 |
| esv2319425 | CNV | deletion | 18987734 |
| esv2675981 | CNV | deletion | 23128226 |
| esv2749782 | CNV | deletion | 23290073 |
| esv2749783 | CNV | deletion | 23290073 |
| esv3337124 | CNV | insertion | 20981092 |
| esv3552562 | CNV | deletion | 23714750 |
| esv3636733 | CNV | loss | 21293372 |
| esv3892709 | CNV | loss | 25118596 |
| esv4243 | CNV | loss | 18987735 |
| nsv94581 | CNV | deletion | 16902084 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PCLAF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PCLAF
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCLAF Gene
Disorders for PCLAF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| posterolateral myocardial infarction |
|
|
| hepatitis c virus |
|
|
| heart conduction disease |
|
|
| lateral myocardial infarction |
|
|
| blue toe syndrome |
|
|
Search PCLAF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PCLAF
No data available for UniProtKB/Swiss-Prot and Genatlas for PCLAF Gene
Publications for PCLAF Gene
- p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. (PMID: 11313979) Yu P … Luo Y (Oncogene 2001) 2 3 4 22 58
- The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. (PMID: 16288740) Simpson F … Wicking C (Experimental cell research 2006) 2 3 4 58
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen LK … Choudhary C (Nature cell biology 2012) 3 4 58
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. (PMID: 21628590) Emanuele MJ … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
- Regulation of ubiquitin chain initiation to control the timing of substrate degradation. (PMID: 21700221) Williamson A … Rape M (Molecular cell 2011) 3 4 58
Products for PCLAF Gene
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- Plasmid Preparation
- GenScript Custom Peptide Services for PCLAF
- Sino Biological Human cDNA Clone for PCLAF
- Sino Biological Recombinant Proteins for PCLAF
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PCLAF
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PCLAF
- Novus Biologicals lysates and proteins for PCLAF
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PCLAF
- Abcam proteins for PCLAF
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PCLAF
- VectorBuilder custom plasmid, inducible vectors for PCLAF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PCLAF
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 81 available KIAA0101 Antibodies ranked by validation data
- Compare Top KIAA0101 Antibodies
- antibodies-online: Search results for 19 available KIAA0101 Elisa Kits ranked by validation data
- Compare Top KIAA0101 Elisa Kits
- antibodies-online: Search results for 11 available KIAA0101 Proteins ranked by validation data
- Compare Top KIAA0101 Proteins
- Search GeneTex for Antibodies for PCLAF
- Search GeneTex for Proteins for PCLAF
- Horizon Cell Lines for PCLAF
- genomics-online: cdna clones - Search results for available KIAA0101 gene related products
- orf clones - Search results for available KIAA0101 gene related products
- genomics-online: gRNA clones - Search results for available KIAA0101 gene related products
- genomics-online: primer clones - Search results for available KIAA0101 gene related products
- genomics-online: shRNA clones - Search results for available KIAA0101 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCLAF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCLAF
- GeneCopoeia miRNA 3'UTR Target clone products for PCLAF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCLAF
Sources for PCLAF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt