Aliases for PCGF5 Gene
External Ids for PCGF5 Gene
Previous HGNC Symbols for PCGF5 Gene
Previous GeneCards Identifiers for PCGF5 Gene
GeneCards Summary for PCGF5 Gene
PCGF5 (Polycomb Group Ring Finger 5) is a Protein Coding gene. Diseases associated with PCGF5 include Brill-Zinsser Disease. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. An important paralog of this gene is PCGF3.
UniProtKB/Swiss-Prot Summary for PCGF5 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).