Aliases for PCGF3 Gene
External Ids for PCGF3 Gene
Previous HGNC Symbols for PCGF3 Gene
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCGF3 Gene
PCGF3 (Polycomb Group Ring Finger 3) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. An important paralog of this gene is PCGF5.
UniProtKB/Swiss-Prot Summary for PCGF3 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).