Aliases for PCGF2 Gene
External Ids for PCGF2 Gene
Previous HGNC Symbols for PCGF2 Gene
Previous GeneCards Identifiers for PCGF2 Gene
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCGF2 Gene
PCGF2 (Polycomb Group Ring Finger 2) is a Protein Coding gene. Diseases associated with PCGF2 include Turnpenny-Fry Syndrome and External Ear Disease. Among its related pathways are Metabolism of proteins and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and ubiquitin-protein transferase activity. An important paralog of this gene is BMI1.
UniProtKB/Swiss-Prot Summary for PCGF2 Gene
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).