Aliases for PCGF2 Gene
Aliases for PCGF2 Gene
External Ids for PCGF2 Gene
- HGNC: 12929
- Entrez Gene: 7703
- Ensembl: ENSG00000277258
- OMIM: 600346
- UniProtKB: P35227
Previous HGNC Symbols for PCGF2 Gene
- ZNF144
- RNF110
Previous GeneCards Identifiers for PCGF2 Gene
- GC17M034144
- GC17M036890
- GC17M032686
Summaries for PCGF2 Gene
-
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCGF2 Gene
PCGF2 (Polycomb Group Ring Finger 2) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and ubiquitin-protein transferase activity. An important paralog of this gene is BMI1.
UniProtKB/Swiss-Prot for PCGF2 Gene
-
Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF2 Gene
Genomics for PCGF2 Gene
GeneHancer (GH) Regulatory Elements for PCGF2 Gene
Promoters and enhancers for PCGF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PCGF2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PCGF2 gene promoter:
-
- YY1
- p300
- LCR-F1
- AREB6
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- MyoD
- Ik-3
Regulatory Element Products
Genomic Locations for PCGF2 Gene
Genomic Locations for PCGF2 Gene
- chr17:38,733,897-38,749,817
- (GRCh38/hg38)
- Size:
- 15,921 bases
- Orientation:
- Minus strand
- chr17:36,890,150-36,906,070
- (GRCh37/hg19)
- Size:
- 15,921 bases
- Orientation:
- Minus strand
Genomic View for PCGF2 Gene
Genes around PCGF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
PCGF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PCGF2 Gene
Proteins for PCGF2 Gene
-
Protein details for PCGF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35227-PCGF2_HUMAN
- Recommended name:
- Polycomb group RING finger protein 2
- Protein Accession:
- P35227
- A6NGD8
Protein attributes for PCGF2 Gene
- Size:
- 344 amino acids
- Molecular mass:
- 37788 Da
- Quaternary structure:
-
- Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex (PubMed:19636380, PubMed:21282530, PubMed:26151332). Interacts with CBX8, RING1 AND RNF2 (PubMed:19636380). Interacts with CBX7 (By similarity). Interacts with PHC2 (By similarity).
Protein Expression for PCGF2 Gene
Post-translational modifications for PCGF2 Gene
- Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PCGF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PCGF2
- Novus Biologicals Antibodies for PCGF2
-
Abcam antibodies for PCGF2
- Invitrogen Antibodies for PCGF2 (AFLGC-PCGF2)
- GeneTex PCGF2 Antibody for PCGF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PCGF2
Protein Products
-
OriGene Purified Proteins for PCGF2
- Search Origene for MassSpec and Protein Over-expression Lysates for PCGF2
- Origene Custom Protein Services for PCGF2
- Search GeneTex for Proteins for PCGF2
-
Abcam proteins for PCGF2
Assay Products
No data available for DME Specific Peptides for PCGF2 Gene
Domains & Families for PCGF2 Gene
Gene Families for PCGF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PCGF2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PCGF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PCGF2 Gene
Function for PCGF2 Gene
Molecular function for PCGF2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Phenotypes From GWAS Catalog for PCGF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 8325509 |
| GO:0005515 | protein binding | IPI | 16182291 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PCGF2 Gene
- MGI mutant phenotypes for PCGF2:
-
inferred from 3 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for PCGF2:
Animal Models for PCGF2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PCGF2
-
CRISPR Products
-
OriGene CRISPR knockouts for PCGF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCGF2
- genomics-online: gRNA clones - Search results for available PCGF2 gene related products
- Applied Biological Materials CRISPR for PCGF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCGF2
- GenScript: Design CRISPR guide RNA sequences for PCGF2
miRNA for PCGF2 Gene
- miRTarBase miRNAs that target PCGF2
-
- hsa-mir-33a-5p (MIRT028183)
- hsa-mir-296-3p (MIRT038479)
- hsa-mir-548t-3p (MIRT076945)
- hsa-mir-548aa (MIRT076947)
- hsa-mir-548ap-3p (MIRT076951)
- hsa-mir-1277-5p (MIRT522008)
- hsa-mir-493-5p (MIRT522009)
- hsa-mir-190a-3p (MIRT522010)
- hsa-mir-340-5p (MIRT522011)
- hsa-mir-5011-5p (MIRT522012)
- hsa-mir-3163 (MIRT522013)
- hsa-mir-5580-3p (MIRT522014)
- hsa-mir-548ay-3p (MIRT522015)
- hsa-mir-548at-3p (MIRT522016)
- hsa-mir-548as-3p (MIRT522017)
- hsa-mir-384 (MIRT707976)
- hsa-mir-3685 (MIRT707977)
- hsa-mir-337-3p (MIRT707978)
- hsa-mir-202-5p (MIRT707979)
- hsa-mir-21-5p (MIRT733305)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCGF2
- Browse OriGene Inhibitory RNA Products For PCGF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCGF2
- genomics-online: shRNA clones - Search results for available PCGF2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PCGF2
- Addgene plasmids for PCGF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCGF2
- genomics-online: cdna clones - Search results for available PCGF2 gene related products
- orf clones - Search results for available PCGF2 gene related products
- Applied Biological Materials Clones for PCGF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PCGF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCGF2 Gene
Localization for PCGF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PCGF2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 19636380 |
| GO:0001739 | sex chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016604 | nuclear body | IEA | -- |
Pathways & Interactions for PCGF2 Gene
Pathways by source for PCGF2 Gene
1 KEGG pathway for PCGF2 Gene
Interacting Proteins for PCGF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for SIGNOR curated interactions for PCGF2 Gene
Transcripts for PCGF2 Gene
mRNA/cDNA for PCGF2 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (324) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000616199 3062 bps (uc060eng.1)
- ENST00000610747 459 bps (uc060enh.1)
- ENST00000611883 2179 bps (uc060eni.1)
- ENST00000616129 1534 bps (uc060enj.1)
- ENST00000618941 1499 bps (uc060enk.1)
Unigene Clusters for PCGF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PCGF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PCGF2
- genomics-online: gRNA clones - Search results for available PCGF2 gene related products
- Applied Biological Materials CRISPR for PCGF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PCGF2
- GenScript: Design CRISPR guide RNA sequences for PCGF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PCGF2
- Browse OriGene Inhibitory RNA Products For PCGF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCGF2
- genomics-online: shRNA clones - Search results for available PCGF2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PCGF2
- Addgene plasmids for PCGF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PCGF2
- genomics-online: cdna clones - Search results for available PCGF2 gene related products
- orf clones - Search results for available PCGF2 gene related products
- Applied Biological Materials Clones for PCGF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PCGF2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCGF2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PCGF2 Gene:
PCGF2SOURCE GeneReport for Unigene cluster for PCGF2 Gene:
Hs.371617mRNA Expression by UniProt/SwissProt for PCGF2 Gene:
P35227-PCGF2_HUMAN
Tissue specificity:
Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
Evidence on tissue expression from TISSUES for PCGF2 Gene
- Intestine(4.2)
- Nervous system(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for PCGF2
-
OriGene qPCR primer pairs and template standards for PCGF2
- genomics-online: primer clones - Search results for available PCGF2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCGF2 Gene
Orthologs for PCGF2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PCGF2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PCGF2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PCGF2 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pcgf2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pcgf2 16 33 |
|
||
| chicken (Gallus gallus) |
Aves | PCGF2 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pcgf2 33 |
|
- Species where no ortholog for PCGF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for PCGF2 Gene
- ENSEMBL:
- Gene Tree for PCGF2 (if available)
- TreeFam:
- Gene Tree for PCGF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PCGF2: view image
Paralogs for PCGF2 Gene
Variants for PCGF2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000304779 | -- | 38,736,662(-) | G/A | intron_variant | |
| rs1000440255 | -- | 38,736,764(-) | G/A | intron_variant | |
| rs1000556927 | -- | 38,747,616(-) | G/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000572430 | -- | 38,736,518(-) | G/A | intron_variant | |
| rs1000621822 | -- | 38,741,542(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PCGF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCGF2 Gene
Disorders for PCGF2 Gene
Additional Disease Information for PCGF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PCGF2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF2 Gene
Publications for PCGF2 Gene
- Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. (PMID: 8325509) Ishida A … Kanno M (Gene 1993) 2 3 4 22 58
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 22 58
- The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. (PMID: 19585577) Wang W … Habuchi T (International journal of cancer 2009) 3 22 44 58
- BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. (PMID: 26151332) Taherbhoy AM … Cochran AG (Nature communications 2015) 3 4 58
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4 58
Products for PCGF2 Gene
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- antibodies-online: Search results for 70 available PCGF2 Antibodies ranked by validation data
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- antibodies-online: Search results for 4 available PCGF2 Proteins ranked by validation data
- Compare Top PCGF2 Proteins
- GeneTex PCGF2 Antibody for PCGF2
- Search GeneTex for Proteins for PCGF2
- Santa Cruz Biotechnology (SCBT) Antibodies for PCGF2
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- Horizon Cell Lines for PCGF2
- genomics-online: cdna clones - Search results for available PCGF2 gene related products
- orf clones - Search results for available PCGF2 gene related products
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Sources for PCGF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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