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Aliases for PCED1A Gene

Aliases for PCED1A Gene

  • PC-Esterase Domain Containing 1A 2 3 5
  • Family With Sequence Similarity 113, Member A 2 3
  • Sarcoma Antigen NY-SAR-23 3 4
  • C20orf81 3 4
  • FAM113A 3 4
  • PC-Esterase Domain-Containing Protein 1A 3
  • Chromosome 20 Open Reading Frame 81 2
  • Protein FAM113A 4
  • BA12M19.1 3

External Ids for PCED1A Gene

Previous HGNC Symbols for PCED1A Gene

  • C20orf81
  • FAM113A

Summaries for PCED1A Gene

Entrez Gene Summary for PCED1A Gene

  • The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

GeneCards Summary for PCED1A Gene

PCED1A (PC-Esterase Domain Containing 1A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is PCED1B.

Additional gene information for PCED1A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCED1A Gene

Genomics for PCED1A Gene

GeneHancer (GH) Regulatory Elements for PCED1A Gene

Promoters and enhancers for PCED1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I002839 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.6 +0.4 355 2.5 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF213 E2F8 ZNF207 PCED1A VPS16 NOP56 GNRH2
GH20I003044 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.7 -204.7 -204712 2.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B MRPS26 PCED1A VPS16 ZNF343 ADAM33 ITPA GNRH2 GC20P003063
GH20I002870 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -31.4 -31375 4.7 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 PTPRA VPS16 PCED1A NOP56 ENSG00000241690 TMEM239 C20orf141 ITPA GC20M002886
GH20I002101 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +738.2 738172 4.1 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 STK35 GC20M002101 SNRPB VPS16 ZNF343 ACTG1P3 NOP56 ENSG00000229728 PCED1A GC20M002129
GH20I003809 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 12.5 -970.7 -970744 4.7 HDGF PKNOX1 CLOCK FOXA2 ARNT MLX ZFP64 ARID4B NEUROD1 SIN3A ENSG00000274949 GC20M003810 VPS16 ENSG00000229539 ADAM33 UBOX5 PCED1A C20orf194 MAVS CDC25B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCED1A on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCED1A Gene

Genomic Locations for PCED1A Gene
5,930 bases
Minus strand

Genomic View for PCED1A Gene

Genes around PCED1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCED1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCED1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCED1A Gene

Proteins for PCED1A Gene

  • Protein details for PCED1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PC-esterase domain-containing protein 1A
    Protein Accession:
    Secondary Accessions:
    • Q5JUA5
    • Q5JUA6
    • Q6PK19
    • Q86WF5
    • Q96CG7
    • Q9H1Q6
    • Q9H6D1

    Protein attributes for PCED1A Gene

    454 amino acids
    Molecular mass:
    51782 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO65166.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCED1A Gene


neXtProt entry for PCED1A Gene

Post-translational modifications for PCED1A Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCED1A Gene

Domains & Families for PCED1A Gene

Gene Families for PCED1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PCED1A Gene


Suggested Antigen Peptide Sequences for PCED1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PC-esterase family.
  • Belongs to the PC-esterase family.
genes like me logo Genes that share domains with PCED1A: view

Function for PCED1A Gene

Gene Ontology (GO) - Molecular Function for PCED1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PCED1A: view
genes like me logo Genes that share phenotypes with PCED1A: view

Animal Models for PCED1A Gene

MGI Knock Outs for PCED1A:

Animal Model Products

CRISPR Products

miRNA for PCED1A Gene

miRTarBase miRNAs that target PCED1A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCED1A Gene

Localization for PCED1A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCED1A gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PCED1A Gene

Pathways & Interactions for PCED1A Gene

SuperPathways for PCED1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCED1A Gene


No data available for Pathways by source and SIGNOR curated interactions for PCED1A Gene

Drugs & Compounds for PCED1A Gene

No Compound Related Data Available

Transcripts for PCED1A Gene

Unigene Clusters for PCED1A Gene

PC-esterase domain containing 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCED1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP7: - - -
SP8: - -

Relevant External Links for PCED1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCED1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCED1A Gene

NURSA nuclear receptor signaling pathways regulating expression of PCED1A Gene:


SOURCE GeneReport for Unigene cluster for PCED1A Gene:

genes like me logo Genes that share expression patterns with PCED1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCED1A Gene

Orthologs for PCED1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PCED1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCED1A 33 34
  • 99.78 (n)
(Canis familiaris)
Mammalia PCED1A 33 34
  • 91.56 (n)
(Mus musculus)
Mammalia Pced1a 33 16 34
  • 85.37 (n)
(Bos Taurus)
Mammalia PCED1A 33 34
  • 84.54 (n)
(Rattus norvegicus)
Mammalia Pced1a 33
  • 82.66 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
(Danio rerio)
Actinopterygii fam113 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea D2030.8 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8488 34
  • 26 (a)
Species where no ortholog for PCED1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCED1A Gene

Gene Tree for PCED1A (if available)
Gene Tree for PCED1A (if available)

Paralogs for PCED1A Gene

Paralogs for PCED1A Gene

(2) SIMAP similar genes for PCED1A Gene using alignment to 2 proteins: Pseudogenes for PCED1A Gene

genes like me logo Genes that share paralogs with PCED1A: view

Variants for PCED1A Gene

Sequence variations from dbSNP and Humsavar for PCED1A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000067326 -- 2,841,068(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000133986 -- 2,840,141(-) G/A intron_variant
rs1000250978 -- 2,835,310(-) G/A downstream_transcript_variant
rs1000390265 -- 2,840,592(-) G/A 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000523206 -- 2,840,764(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PCED1A Gene

Variant ID Type Subtype PubMed ID
nsv952978 CNV deletion 24416366
nsv833895 CNV loss 17160897
nsv522009 CNV gain 19592680
nsv3261 CNV deletion 18451855
nsv1057464 CNV gain 25217958
esv3645020 CNV gain 21293372
esv2762056 CNV gain 21179565

Variation tolerance for PCED1A Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCED1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCED1A Gene

Disorders for PCED1A Gene

Additional Disease Information for PCED1A

No disorders were found for PCED1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCED1A Gene

Publications for PCED1A Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V … Aravind L (Biology direct 2010) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for PCED1A Gene

Sources for PCED1A Gene

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