Aliases for PCDHGC3 Gene
External Ids for PCDHGC3 Gene
Previous HGNC Symbols for PCDHGC3 Gene
Previous GeneCards Identifiers for PCDHGC3 Gene
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCDHGC3 Gene
PCDHGC3 (Protocadherin Gamma Subfamily C, 3) is a Protein Coding gene. Diseases associated with PCDHGC3 include Nonsyndromic Deafness. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGB2.
UniProtKB/Swiss-Prot for PCDHGC3 Gene
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.