This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, sub... See more...

Aliases for PCDHGA10 Gene

Aliases for PCDHGA10 Gene

  • Protocadherin Gamma Subfamily A, 10 2 3 5
  • Protocadherin Gamma-A10 3 4
  • PCDH-GAMMA-A10 2 3
  • PCDH-Gamma-A10 4
  • PCDHGA10 5

External Ids for PCDHGA10 Gene

Previous GeneCards Identifiers for PCDHGA10 Gene

  • GC05P140595
  • GC05P141315
  • GC05P140719
  • GC05P140777
  • GC05P140798
  • GC05P140737
  • GC05P140741
  • GC05P140854
  • GC05P140875
  • GC05P140880
  • GC05P140900
  • GC05P140934
  • GC05P140956
  • GC05P140977
  • GC05P141001
  • GC05P141016
  • GC05P141032
  • GC05P135937
  • GC05P141113
  • GC05P141155
  • GC05P141173
  • GC05P141207
  • GC05P141247
  • GC05P141334
  • GC05P141390
  • GC05P141457
  • GC05P141535
  • GC05P142457
  • GC05P142561
  • GC05P142672
  • GC05P142872
  • GC05P141638
  • GC05P141739
  • GC05P141838
  • GC05P141941
  • GC05P142045
  • GC05P142153
  • GC05P142251
  • GC05P142353

Summaries for PCDHGA10 Gene

Entrez Gene Summary for PCDHGA10 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA10 Gene

PCDHGA10 (Protocadherin Gamma Subfamily A, 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA8.

UniProtKB/Swiss-Prot Summary for PCDHGA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Additional gene information for PCDHGA10 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCDHGA10 Gene

Genomics for PCDHGA10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PCDHGA10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCDHGA10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCDHGA10

Top Transcription factor binding sites by QIAGEN in the PCDHGA10 gene promoter:
  • AhR
  • c-Ets-1
  • COMP1
  • CREB
  • deltaCREB
  • FOXD3
  • HOXA5
  • Max
  • p300

Genomic Locations for PCDHGA10 Gene

Genomic Locations for PCDHGA10 Gene
chr5:141,412,987-141,512,979
(GRCh38/hg38)
Size:
99,993 bases
Orientation:
Plus strand
chr5:140,792,743-140,892,546
(GRCh37/hg19)
Size:
99,804 bases
Orientation:
Plus strand

Genomic View for PCDHGA10 Gene

Genes around PCDHGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA10 Gene

Proteins for PCDHGA10 Gene

  • Protein details for PCDHGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5H3-PCDGA_HUMAN
    Recommended name:
    Protocadherin gamma-A10
    Protein Accession:
    Q9Y5H3
    Secondary Accessions:
    • Q9Y5E0

    Protein attributes for PCDHGA10 Gene

    Size:
    936 amino acids
    Molecular mass:
    101447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA10 Gene

Post-translational modifications for PCDHGA10 Gene

  • Glycosylation at Asn51, Asn423, and Asn549
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA10 Gene

Domains & Families for PCDHGA10 Gene

Gene Families for PCDHGA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PCDHGA10 Gene

Suggested Antigen Peptide Sequences for PCDHGA10 Gene

GenScript: Design optimal peptide antigens:
  • Protocadherin gamma-A10 (PCDGA_HUMAN)
  • Protocadherin gamma subfamily A, 10 (Q52LL2_HUMAN)
genes like me logo Genes that share domains with PCDHGA10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PCDHGA10 Gene

Function for PCDHGA10 Gene

Molecular function for PCDHGA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Phenotypes From GWAS Catalog for PCDHGA10 Gene

Gene Ontology (GO) - Molecular Function for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view
genes like me logo Genes that share phenotypes with PCDHGA10: view

Animal Model Products

CRISPR Products

miRNA for PCDHGA10 Gene

miRTarBase miRNAs that target PCDHGA10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCDHGA10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHGA10 Gene

Localization for PCDHGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDHGA10 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view

Pathways & Interactions for PCDHGA10 Gene

PathCards logo

SuperPathways for PCDHGA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCDHGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGA10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHGA10 Gene

Drugs & Compounds for PCDHGA10 Gene

(1) Drugs for PCDHGA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with PCDHGA10: view

Transcripts for PCDHGA10 Gene

mRNA/cDNA for PCDHGA10 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCDHGA10

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA10 Gene

No ASD Table

Relevant External Links for PCDHGA10 Gene

GeneLoc Exon Structure for
PCDHGA10

Expression for PCDHGA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCDHGA10 Gene

Protein differential expression in normal tissues from HIPED for PCDHGA10 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCDHGA10 Gene



Protein tissue co-expression partners for PCDHGA10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCDHGA10

Evidence on tissue expression from TISSUES for PCDHGA10 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PCDHGA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHGA10 Gene

Orthologs for PCDHGA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA10 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia PCDHGA10 30
  • 87.97 (n)
Dog
(Canis familiaris)
Mammalia PCDHGA10 30
  • 85.4 (n)
Rat
(Rattus norvegicus)
Mammalia Pcdhga10 30
  • 84.79 (n)
Mouse
(Mus musculus)
Mammalia Pcdhga10 30 17
  • 84.59 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 71 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 52 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
Species where no ortholog for PCDHGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PCDHGA10 Gene

ENSEMBL:
Gene Tree for PCDHGA10 (if available)
TreeFam:
Gene Tree for PCDHGA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCDHGA10: view image

Paralogs for PCDHGA10 Gene

genes like me logo Genes that share paralogs with PCDHGA10: view

Variants for PCDHGA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCDHGA10 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
720930 Likely Benign: not provided 141,413,426(+) G/T MISSENSE_VARIANT,INTRON_VARIANT
736375 Likely Benign: not provided 141,413,207(+) C/G NONSENSE,INTRON_VARIANT
776069 Likely Benign: not provided 141,415,107(+) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT
780961 Benign: not provided 141,413,826(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
782455 Likely Benign: not provided 141,415,363(+) C/T NONSENSE,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PCDHGA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA10 Gene

Variant ID Type Subtype PubMed ID
esv25744 CNV gain 19812545
esv2730847 CNV deletion 23290073
esv2759382 CNV gain 17122850
esv3606987 CNV gain 21293372
nsv1123990 CNV deletion 24896259
nsv1125852 CNV tandem duplication 24896259
nsv327707 CNV deletion 16902084
nsv462470 CNV loss 19166990
nsv518799 CNV loss 19592680
nsv519627 CNV loss 19592680
nsv599922 CNV loss 21841781
nsv599923 CNV loss 21841781
nsv980740 CNV duplication 23825009

Variation tolerance for PCDHGA10 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCDHGA10 Gene

Human Gene Mutation Database (HGMD)
PCDHGA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHGA10 Gene

Disorders for PCDHGA10 Gene

Additional Disease Information for PCDHGA10

No disorders were found for PCDHGA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCDHGA10 Gene

Publications for PCDHGA10 Gene

  1. A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 4
  2. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. (PMID: 30631154) Hu Q … Yang L (Cell research 2019) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for PCDHGA10 Gene

  • Biorbyt antibodies for PCDHGA10

Sources for PCDHGA10 Gene