Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCDHG@ Gene

Aliases for PCDHG@ Gene

  • Protocadherin Gamma Cluster 2 3
  • Protocadherin Gamma Cluster Extended 3
  • PCDH2 3
  • PCDH4 3
  • PCDHG 3

External Ids for PCDHG@ Gene

Previous GeneCards Identifiers for PCDHG@ Gene

  • GC05U990121
  • GC05P141095
  • GC05P141129
  • GC05P141432
  • GC05P141556
  • GC05P141660
  • GC05P141760
  • GC05P141861
  • GC05P141970
  • GC05P142068

Summaries for PCDHG@ Gene

Entrez Gene Summary for PCDHG@ Gene

  • The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma cluster includes 22 genes divided into 3 subfamilies, all part of the cadherin superfamily. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. In addition, ORNT2 and TAF2F are included in the cluster due to their localization between protocadherin clusters beta and gamma on chromosome five. The protocadherin genes are organized in a tandem array of 22 large, variable region exons followed by a constant region, which contains 3 exons shared by all protocadherin genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHG@ Gene

PCDHG@ (Protocadherin Gamma Cluster) is a Gene Cluster. Diseases associated with PCDHG@ include Protocadherin-Gamma Gene Cluster.

Additional gene information for PCDHG@ Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHG@ Gene

Genomics for PCDHG@ Gene

GeneHancer (GH) Regulatory Elements for PCDHG@ Gene

Promoters and enhancers for PCDHG@ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I141331 Promoter 1.3 EPDnew Ensembl 550.8 -0.2 -185 0.2 ZNF335 CTCF ZNF654 TEAD1 ZNF143 ZNF384 RAD21 PCDHG@ PCDHGA1 GC05M141306
GH05I141330 Promoter 0.7 EPDnew 550.8 +0.1 75 0.1 ZNF335 CTCF PCDHG@ PCDHGA1 PCDHGA2
GH05I141332 Enhancer 0.3 Ensembl 550.8 +0.2 216 0.2 CTCF PCDHGA1 PCDHG@ PCDHGA2
GH05I141349 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.4 +19.5 19513 0.4 ELF3 ARID4B SIN3A ZNF2 RAD21 ZNF335 ZNF143 SMARCA5 ZNF654 ZBTB11 ENSG00000280026 PCDHGB1 PCDHGA3 PCDHGA2 PCDHG@ PCDHGA1
GH05I141334 Enhancer 0.6 FANTOM5 0.8 +3.8 3791 0 KLF1 SP3 SP2 KLF4 ZNF335 POLR2A VEZF1 GABPB1 CREM PCDHB15 PCDHGC4 PCDHB12 PCDHG@ PCDHGA1 PCDHGA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCDHG@ on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCDHG@ Gene

Genomic Locations for PCDHG@ Gene
chr5:141,330,685-141,512,979
(GRCh38/hg38)
Size:
182,295 bases
Orientation:
Plus strand

Genomic View for PCDHG@ Gene

Genes around PCDHG@ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHG@ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHG@ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHG@ Gene

Proteins for PCDHG@ Gene

Post-translational modifications for PCDHG@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHG@ Gene

Domains & Families for PCDHG@ Gene

Gene Families for PCDHG@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHG@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHG@ Gene

Function for PCDHG@ Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHG@ Gene

Localization for PCDHG@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PCDHG@ Gene

Pathways & Interactions for PCDHG@ Gene

SuperPathways for PCDHG@ Gene

No Data Available

Interacting Proteins for PCDHG@ Gene

Gene Ontology (GO) - Biological Process for PCDHG@ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCDHG@ Gene

Drugs & Compounds for PCDHG@ Gene

No Compound Related Data Available

Transcripts for PCDHG@ Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHG@ Gene

No ASD Table

Relevant External Links for PCDHG@ Gene

GeneLoc Exon Structure for
PCDHG@
ECgene alternative splicing isoforms for
PCDHG@

No data available for mRNA/cDNA for PCDHG@ Gene

Expression for PCDHG@ Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHG@ Gene:

PCDHG@
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHG@ Gene

Orthologs for PCDHG@ Gene

No data available for Orthologs and Evolution for PCDHG@ Gene

Paralogs for PCDHG@ Gene

No data available for Paralogs for PCDHG@ Gene

Variants for PCDHG@ Gene

Additional Variant Information for PCDHG@ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHG@

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PCDHG@ Gene

Disorders for PCDHG@ Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCDHG@ Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
protocadherin-gamma gene cluster
  • pcdhg@
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PCDHG@: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for PCDHG@ Gene

Publications for PCDHG@ Gene

  1. Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. (PMID: 19956686) Dallosso AR … Malik K (PLoS genetics 2009) 3 22 58
  2. A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 58
  3. Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact. (PMID: 19776259) Garrett AM … Weiner JA (The Journal of neuroscience : the official journal of the Society for Neuroscience 2009) 22 58
  4. Gamma protocadherin expression in the embryonic chick nervous system. (PMID: 17200686) Cronin KD … Capehart AA (International journal of biological sciences 2006) 22 58
  5. Differential expression of individual gamma-protocadherins during mouse brain development. (PMID: 15964765) Frank M … Kemler R (Molecular and cellular neurosciences 2005) 22 58

Products for PCDHG@ Gene

Sources for PCDHG@ Gene

Content
Loading form....