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Aliases for PCDHA@ Gene

Aliases for PCDHA@ Gene

  • Protocadherin Alpha Cluster, Complex Locus 2 3
  • Protocadherin Alpha Cluster 2 3
  • Cadherin-Related Neuronal Receptor 1 3
  • CNRS1 3
  • CNR1 3

External Ids for PCDHA@ Gene

Previous HGNC Symbols for PCDHA@ Gene

  • CNRS1

Previous GeneCards Identifiers for PCDHA@ Gene

  • GC05U990123
  • GC05P140147
  • GC05P141362
  • GC05P141544
  • GC05P141651
  • GC05P141751
  • GC05P141852
  • GC05P141959
  • GC05P142060

Summaries for PCDHA@ Gene

Entrez Gene Summary for PCDHA@ Gene

  • The protocadherin alpha gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have a genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 genes and 1 pseudogene, which are members of the cadherin superfamily and related to the mouse CNR genes. The sequence of the 13 upstream genes and the pseudogene are highly similar to one another, while a subfamily (C) contains two more distantly related coding sequences. The alpha cluster genes are organized in a tandem array of 15 large, variable region exons followed by a constant region, which contains 3 exons shared by all genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the alpha cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA@ Gene

PCDHA@ (Protocadherin Alpha Cluster, Complex Locus) is a Gene Cluster. Diseases associated with PCDHA@ include Protocadherin-Alpha Gene Cluster.

Additional gene information for PCDHA@ Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA@ Gene

Genomics for PCDHA@ Gene

GeneHancer (GH) Regulatory Elements for PCDHA@ Gene

Promoters and enhancers for PCDHA@ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140786 Promoter 0.8 EPDnew 550.8 -0.2 -170 0.1 CTCF PKNOX1 GATA3 ZNF654 ZNF2 RAD21 PCDHA1 PCDHA@ PIR48875 GC05P142218
GH05I140801 Promoter 1.1 EPDnew Ensembl 0.4 +15.0 15001 0.2 CTCF PCDHA3 PCDHGA11 PCDHA2 PCDHA4 PCDHA1 PCDHA@ ENSG00000279726
GH05I140802 Promoter 0.7 EPDnew 0.4 +14.8 14758 0.1 CTCF ZNF654 PCDHA3 PCDHA2 PCDHA4 PCDHA1 PCDHA@ ENSG00000279726
GH05I140794 Promoter 0.6 EPDnew 0.4 +8.6 8644 0.1 CTCF PCDHA2 PCDHA1 PCDHA3 PCDHA@ ENSG00000279726
GH05I140795 Promoter 0.6 EPDnew 0.4 +8.5 8542 0.1 CTCF PCDHA2 PCDHA1 PCDHA@ ENSG00000279726
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCDHA@ on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCDHA@ Gene

Genomic Locations for PCDHA@ Gene
226,054 bases
Plus strand

Genomic View for PCDHA@ Gene

Genes around PCDHA@ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHA@ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHA@ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA@ Gene

Proteins for PCDHA@ Gene

Post-translational modifications for PCDHA@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCDHA@ Gene

Domains & Families for PCDHA@ Gene

Gene Families for PCDHA@ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHA@: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PCDHA@ Gene

Function for PCDHA@ Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCDHA@ Gene

Localization for PCDHA@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PCDHA@ Gene

Pathways & Interactions for PCDHA@ Gene

SuperPathways for PCDHA@ Gene

No Data Available

Interacting Proteins for PCDHA@ Gene

Gene Ontology (GO) - Biological Process for PCDHA@ Gene


No data available for Pathways by source and SIGNOR curated interactions for PCDHA@ Gene

Drugs & Compounds for PCDHA@ Gene

No Compound Related Data Available

Transcripts for PCDHA@ Gene

mRNA/cDNA for PCDHA@ Gene

(66) Additional mRNA sequences :

Unigene Clusters for PCDHA@ Gene

Protocadherin alpha cluster, complex locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA@ Gene

No ASD Table

Relevant External Links for PCDHA@ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHA@ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCDHA@ Gene

mRNA expression in normal human tissues for PCDHA@ Gene

NURSA nuclear receptor signaling pathways regulating expression of PCDHA@ Gene:


SOURCE GeneReport for Unigene cluster for PCDHA@ Gene:

genes like me logo Genes that share expression patterns with PCDHA@: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHA@ Gene

Orthologs for PCDHA@ Gene

No data available for Orthologs and Evolution for PCDHA@ Gene

Paralogs for PCDHA@ Gene

No data available for Paralogs for PCDHA@ Gene

Variants for PCDHA@ Gene

Additional Variant Information for PCDHA@ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PCDHA@ Gene

Disorders for PCDHA@ Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCDHA@ Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
protocadherin-alpha gene cluster
  • pcdha@
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PCDHA@

Genetic Association Database
Human Genome Epidemiology Navigator
genes like me logo Genes that share disorders with PCDHA@: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCDHA@ Gene

Publications for PCDHA@ Gene

  1. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PMID: 19054571) Gregório SP … Dias-Neto E (Psychiatry research 2009) 3 44 58
  2. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q … Maniatis T (Genome research 2001) 3 22 58
  3. Genomic organization of the family of CNR cadherin genes in mice and humans. (PMID: 10662547) Sugino H … Yagi T (Genomics 2000) 2 3 58
  4. A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 58
  5. Protocadherin α (PCDHA) as a novel susceptibility gene for autism. (PMID: 23031252) Anitha A … Mori N (Journal of psychiatry & neuroscience : JPN 2013) 3 58

Products for PCDHA@ Gene

Sources for PCDHA@ Gene

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