Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCDHA10 Gene

Aliases for PCDHA10 Gene

  • Protocadherin Alpha 10 2 3 5
  • Ortholog To Mouse CNR8 2 3
  • KIAA0345-Like 4 2 3
  • PCDH-Alpha-10 3 4
  • CNRS8 3 4
  • Protocadherin Alpha-10 3
  • PCDH-ALPHA10 3
  • CNRN8 3
  • CRNR8 3
  • CNR8 3

External Ids for PCDHA10 Gene

Previous HGNC Symbols for PCDHA10 Gene

  • CNRS8

Previous GeneCards Identifiers for PCDHA10 Gene

  • GC05P140052
  • GC05P140757
  • GC05P140159
  • GC05P140202
  • GC05P140195
  • GC05P140166
  • GC05P140226
  • GC05P140231
  • GC05P140236
  • GC05P140244
  • GC05P140254
  • GC05P140263
  • GC05P140273
  • GC05P140282
  • GC05P140293
  • GC05P140303
  • GC05P140312
  • GC05P140323
  • GC05P140344
  • GC05P135380
  • GC05P140356
  • GC05P140371
  • GC05P140386
  • GC05P140400
  • GC05P140416
  • GC05P140429
  • GC05P140448
  • GC05P141274
  • GC05P141494
  • GC05P141601
  • GC05P141701
  • GC05P141803
  • GC05P141901
  • GC05P142010

Summaries for PCDHA10 Gene

Entrez Gene Summary for PCDHA10 Gene

  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHA10 Gene

PCDHA10 (Protocadherin Alpha 10) is a Protein Coding gene. Diseases associated with PCDHA10 include Protocadherin-Alpha Gene Cluster. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHA6.

UniProtKB/Swiss-Prot for PCDHA10 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Additional gene information for PCDHA10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHA10 Gene

Genomics for PCDHA10 Gene

GeneHancer (GH) Regulatory Elements for PCDHA10 Gene

Promoters and enhancers for PCDHA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140855 Promoter 0.9 EPDnew 550.8 +0.0 27 0.1 CTCF ZNF654 ZNF2 RAD21 ZNF335 ZNF213 POLR2A SMC3 MAFK PCDHA10 PCDHA14 PCDHA9 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2
GH05I140036 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.8 -815.4 -815397 7 SIN3A ZNF2 IRF4 GLIS2 ZNF207 ZNF143 ATF7 KLF7 FOS RUNX3 NRG2 PCDHA2 PCDHA3 PCDHA7 PURA PCDHA6 PCDHA10 DNAJC18 PFDN1 MATR3
GH05I140637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 -216.9 -216877 2.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TMCO6 HARS2 ANKHD1 WDR55 HDAC3 LOC102723915 SRA1 PURA MALINC1 CD14
GH05I141319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +464.8 464767 1.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF213 TAF7 PCDHB15 ANKHD1 ENSG00000272108 WDR55 PCDHB9 LOC102723915 FCHSD1 PCDHB18P PCDHB6
GH05I140717 Promoter/Enhancer 1.6 Ensembl ENCODE 11.4 -136.7 -136747 2.7 MLX IRF4 ZNF213 E2F8 ZNF416 ZNF143 SP3 PPARGC1A MEF2D GLIS1 GC05P142207 VTRNA1-2 PURA PCDHB18P PCDHB19P PCDHB15 PCDHB12 PCDHB3 PCDHB9 PCDHB13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCDHA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCDHA10 gene promoter:

Genomic Locations for PCDHA10 Gene

Genomic Locations for PCDHA10 Gene
chr5:140,855,883-141,012,344
(GRCh38/hg38)
Size:
156,462 bases
Orientation:
Plus strand
chr5:140,235,595-140,391,929
(GRCh37/hg19)

Genomic View for PCDHA10 Gene

Genes around PCDHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHA10 Gene

Proteins for PCDHA10 Gene

  • Protein details for PCDHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5I2-PCDAA_HUMAN
    Recommended name:
    Protocadherin alpha-10
    Protein Accession:
    Q9Y5I2
    Secondary Accessions:
    • A1L493
    • O75280
    • Q9NRU2

    Protein attributes for PCDHA10 Gene

    Size:
    948 amino acids
    Molecular mass:
    102875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHA10 Gene

Post-translational modifications for PCDHA10 Gene

  • Glycosylation at Asn256, Asn264, and Asn547

Other Protein References for PCDHA10 Gene

No data available for DME Specific Peptides for PCDHA10 Gene

Domains & Families for PCDHA10 Gene

Gene Families for PCDHA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PCDHA10 Gene

Suggested Antigen Peptide Sequences for PCDHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCDHA10: view

No data available for UniProtKB/Swiss-Prot for PCDHA10 Gene

Function for PCDHA10 Gene

Molecular function for PCDHA10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Phenotypes From GWAS Catalog for PCDHA10 Gene

Gene Ontology (GO) - Molecular Function for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHA10: view
genes like me logo Genes that share phenotypes with PCDHA10: view

Animal Model Products

miRNA for PCDHA10 Gene

miRTarBase miRNAs that target PCDHA10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDHA10 Gene

Localization for PCDHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHA10 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDHA10 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10380929
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHA10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PCDHA10 Gene

Pathways & Interactions for PCDHA10 Gene

SuperPathways for PCDHA10 Gene

No Data Available

Interacting Proteins for PCDHA10 Gene

Gene Ontology (GO) - Biological Process for PCDHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 10380929
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development TAS 10380929
genes like me logo Genes that share ontologies with PCDHA10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDHA10 Gene

Drugs & Compounds for PCDHA10 Gene

(1) Drugs for PCDHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with PCDHA10: view

Transcripts for PCDHA10 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA10 Gene

No ASD Table

Relevant External Links for PCDHA10 Gene

GeneLoc Exon Structure for
PCDHA10
ECgene alternative splicing isoforms for
PCDHA10

Expression for PCDHA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCDHA10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHA10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for PCDHA10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDHA10 Gene



Protein tissue co-expression partners for PCDHA10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCDHA10 Gene:

PCDHA10

Evidence on tissue expression from TISSUES for PCDHA10 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PCDHA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDHA10 Gene

Orthologs for PCDHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDHA10 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia PCDHA10 33
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Pcdha9 33 16
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Pcdha10 33
  • 83.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves PCDHA11 34
  • 53 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii pcdh1a6 34
  • 42 (a)
ManyToMany
pcdh2ab1 34
  • 42 (a)
ManyToMany
pcdh2ab11 34
  • 42 (a)
ManyToMany
pcdh2ab3 34
  • 42 (a)
ManyToMany
pcdh2ab8 34
  • 42 (a)
ManyToMany
AL929558.4 34
  • 41 (a)
ManyToMany
CT573264.5 34
  • 41 (a)
ManyToMany
pcdh1a3 34
  • 41 (a)
ManyToMany
pcdh2ab6 34
  • 41 (a)
ManyToMany
pcdh2ab7 34
  • 41 (a)
ManyToMany
CR847851.3 34
  • 40 (a)
ManyToMany
CR847851.4 34
  • 40 (a)
ManyToMany
CR847851.5 34 34
  • 40 (a)
ManyToMany
CR847851.6 34
  • 40 (a)
ManyToMany
CR847851.8 34
  • 40 (a)
ManyToMany
CT573264.4 34
  • 40 (a)
ManyToMany
pcdh2aa1 34 34
  • 40 (a)
ManyToMany
pcdh2aa15 34
  • 40 (a)
ManyToMany
pcdh2ab10 34
  • 40 (a)
ManyToMany
pcdh2ab2 34 34
  • 40 (a)
ManyToMany
pcdh2ab9 34
  • 40 (a)
ManyToMany
AL929558.3 34
  • 39 (a)
ManyToMany
CR847851.1 34
  • 39 (a)
ManyToMany
pcdh2aa3 34 34
  • 39 (a)
ManyToMany
pcdh2ab12 34 34
  • 39 (a)
ManyToMany
pcdh2ac 34
  • 38 (a)
ManyToMany
CABZ01112358.1 34
  • 36 (a)
ManyToMany
pcdhb 34
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
ManyToMany
CSA.7308 34
  • 19 (a)
ManyToMany
Species where no ortholog for PCDHA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHA10 Gene

ENSEMBL:
Gene Tree for PCDHA10 (if available)
TreeFam:
Gene Tree for PCDHA10 (if available)

Paralogs for PCDHA10 Gene

Variants for PCDHA10 Gene

Sequence variations from dbSNP and Humsavar for PCDHA10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs150254638 uncertain-significance, Hirschsprung disease 1 140,978,974(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs193920994 uncertain-significance, Malignant tumor of prostate 140,857,214(+) C/T coding_sequence_variant, missense_variant
rs139390480 likely-benign, not specified 140,856,945(+) A/T coding_sequence_variant, synonymous_variant
rs386352346 uncertain-significance, not provided 140,929,288(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000122176 -- 140,965,777(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PCDHA10 Gene

Variant ID Type Subtype PubMed ID
dgv10093n54 CNV loss 21841781
dgv10094n54 CNV loss 21841781
dgv10095n54 CNV loss 21841781
dgv10097n54 CNV loss 21841781
dgv10098n54 CNV loss 21841781
dgv10099n54 CNV loss 21841781
dgv10100n54 CNV loss 21841781
dgv10101n54 CNV loss 21841781
dgv10102n54 CNV loss 21841781
dgv10103n54 CNV loss 21841781
dgv10104n54 CNV loss 21841781
dgv10105n54 CNV loss 21841781
dgv1043e199 CNV deletion 23128226
dgv138e203 CNV loss 21179565
dgv1652e212 CNV loss 25503493
dgv1653e212 CNV loss 25503493
dgv3182n106 CNV deletion 24896259
dgv971n67 CNV loss 20364138
esv2421858 CNV deletion 20811451
esv2505753 CNV deletion 19546169
esv26168 CNV gain 19812545
esv2657537 CNV deletion 23128226
esv2730839 CNV deletion 23290073
esv2759382 CNV gain 17122850
esv29977 CNV gain 17803354
esv33939 CNV gain+loss 17666407
esv3566721 CNV deletion 23714750
esv3606958 CNV loss 21293372
esv3606959 CNV gain 21293372
esv3890744 CNV loss 25118596
nsv1031849 CNV loss 25217958
nsv10753 CNV gain 18304495
nsv10754 CNV gain 18304495
nsv1135376 CNV deletion 24896259
nsv1161301 OTHER complex 26073780
nsv442962 CNV loss 18776908
nsv514324 CNV loss 21397061
nsv599841 CNV loss 21841781
nsv599894 CNV loss 21841781
nsv599902 CNV loss 21841781
nsv599903 CNV loss 21841781
nsv599904 CNV loss 21841781
nsv819207 CNV gain 19587683
nsv820841 CNV deletion 20802225
nsv823262 CNV gain 20364138
nsv823263 CNV gain 20364138
nsv823264 CNV gain 20364138
nsv830508 CNV loss 17160897
nsv964954 CNV duplication 23825009
nsv964955 CNV duplication 23825009
nsv964956 CNV duplication 23825009
nsv968252 CNV duplication 23825009
nsv968992 CNV duplication 23825009

Variation tolerance for PCDHA10 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.16; 93.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCDHA10 Gene

Human Gene Mutation Database (HGMD)
PCDHA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDHA10 Gene

Disorders for PCDHA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCDHA10 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
protocadherin-alpha gene cluster
  • pcdha@
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PCDHA10

genes like me logo Genes that share disorders with PCDHA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCDHA10 Gene

Publications for PCDHA10 Gene

  1. A striking organization of a large family of human neural cadherin-like cell adhesion genes. (PMID: 10380929) Wu Q … Maniatis T (Cell 1999) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C … Li SS (Proteomics 2007) 3 58

Products for PCDHA10 Gene

Sources for PCDHA10 Gene

Content
Loading form....