This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connect... See more...

Aliases for PCDH10 Gene

Aliases for PCDH10 Gene

  • Protocadherin 10 2 3 5
  • Protocadherin-10 3 4
  • KIAA1400 4
  • OL-PCDH 3
  • PCDH19 3

External Ids for PCDH10 Gene

Previous GeneCards Identifiers for PCDH10 Gene

  • GC04P135012
  • GC04P134373
  • GC04P134463
  • GC04P134529
  • GC04P134428
  • GC04P134070
  • GC04P129800

Summaries for PCDH10 Gene

Entrez Gene Summary for PCDH10 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for PCDH10 Gene

PCDH10 (Protocadherin 10) is a Protein Coding gene. Diseases associated with PCDH10 include Epileptic Encephalopathy, Early Infantile, 9 and Landau-Kleffner Syndrome. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH17.

UniProtKB/Swiss-Prot Summary for PCDH10 Gene

Gene Wiki entry for PCDH10 Gene

Additional gene information for PCDH10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCDH10 Gene

Genomics for PCDH10 Gene

GeneHancer (GH) Regulatory Elements for PCDH10 Gene

Promoters and enhancers for PCDH10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J133146 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.8 811 9.4 EP300 CTCF SP1 ZBTB26 TRIM28 SAP30 RAD21 TRIM22 NFYB HDAC2 ENSG00000250241 LOC101927359 PCDH10 lnc-C4orf33-9
GH04J133129 Enhancer 0.8 Ensembl ENCODE dbSUPER 8.2 -18.0 -17989 3.4 WT1 FOS GATA2 POLR2A NANOG ENSG00000250241 PCDH10 R3HDM2P1 lnc-PCDH10-10 LOC101927359
GH04J133097 Enhancer 0.6 Ensembl ENCODE 10.4 -52.3 -52289 1.2 TEAD4 POU5F1 NANOG ENSG00000250241 PCDH10 R3HDM2P1 lnc-PCDH10-10 LOC105377432 LOC101927359
GH04J133865 Enhancer 0.8 Ensembl ENCODE 6.7 +716.9 716929 1.9 TCF12 JUND FOS POLR2A FOSL2 CEBPB JUN RCOR1 FOSL1 EZH2 PCDH10 piR-60985-087 HSALNG0037246
GH04J133190 Enhancer 0.4 Ensembl 10.8 +41.0 41011 0.2 TCF7L2 TRIM28 CTBP1 PKNOX1 PCDH10 ENSG00000250241 lnc-C4orf33-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCDH10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCDH10

Top Transcription factor binding sites by QIAGEN in the PCDH10 gene promoter:
  • c-Myb
  • Pax-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP

Genomic Locations for PCDH10 Gene

Genomic Locations for PCDH10 Gene
chr4:133,149,290-133,208,606
(GRCh38/hg38)
Size:
59,317 bases
Orientation:
Plus strand
chr4:134,070,470-134,129,356
(GRCh37/hg19)
Size:
58,887 bases
Orientation:
Plus strand

Genomic View for PCDH10 Gene

Genes around PCDH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCDH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCDH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH10 Gene

Proteins for PCDH10 Gene

  • Protein details for PCDH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E7-PCD10_HUMAN
    Recommended name:
    Protocadherin-10
    Protein Accession:
    Q9P2E7
    Secondary Accessions:
    • Q4W5F6
    • Q96SF0

    Protein attributes for PCDH10 Gene

    Size:
    1040 amino acids
    Molecular mass:
    112936 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDH10 Gene

Post-translational modifications for PCDH10 Gene

  • Glycosylation at Asn273 and Asn557
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDH10 Gene

No data available for DME Specific Peptides for PCDH10 Gene

Domains & Families for PCDH10 Gene

Gene Families for PCDH10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PCDH10 Gene

Suggested Antigen Peptide Sequences for PCDH10 Gene

GenScript: Design optimal peptide antigens:
  • Protocadherin-10 (PCD10_HUMAN)
  • Protocadherin 10 (Q14DV7_HUMAN)
  • cDNA, FLJ95150, Homo sapiens protocadherin 10 (PCDH10), transcript variant 2, mRNA (Q96SF0_HUMAN)
genes like me logo Genes that share domains with PCDH10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PCDH10 Gene

Function for PCDH10 Gene

Molecular function for PCDH10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein.

Phenotypes From GWAS Catalog for PCDH10 Gene

Gene Ontology (GO) - Molecular Function for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDH10: view
genes like me logo Genes that share phenotypes with PCDH10: view

Animal Models for PCDH10 Gene

MGI Knock Outs for PCDH10:

Animal Model Products

  • Taconic Biosciences Mouse Models for PCDH10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCDH10 Gene

Localization for PCDH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCDH10 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDH10: view

Pathways & Interactions for PCDH10 Gene

PathCards logo

SuperPathways for PCDH10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDH10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDH10 Gene

Drugs & Compounds for PCDH10 Gene

(1) Drugs for PCDH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with PCDH10: view

Transcripts for PCDH10 Gene

mRNA/cDNA for PCDH10 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH10 Gene

No ASD Table

Relevant External Links for PCDH10 Gene

GeneLoc Exon Structure for
PCDH10

Expression for PCDH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCDH10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDH10 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Caudate (basal ganglia) (x4.7), and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for PCDH10 Gene

This gene is overexpressed in Amniocyte (40.2) and Fetal Brain (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PCDH10 Gene



Protein tissue co-expression partners for PCDH10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCDH10

SOURCE GeneReport for Unigene cluster for PCDH10 Gene:

Hs.192859

mRNA Expression by UniProt/SwissProt for PCDH10 Gene:

Q9P2E7-PCD10_HUMAN
Tissue specificity: Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.

Evidence on tissue expression from TISSUES for PCDH10 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PCDH10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PCDH10 Gene

Orthologs for PCDH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCDH10 30
  • 99.46 (n)
oppossum
(Monodelphis domestica)
Mammalia PCDH10 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCDH10 30
  • 92.29 (n)
dog
(Canis familiaris)
Mammalia LOC102156925 30
  • 91.68 (n)
mouse
(Mus musculus)
Mammalia Pcdh10 17 31 30
  • 89.72 (n)
chicken
(Gallus gallus)
Aves PCDH10 30
  • 85.2 (n)
lizard
(Anolis carolinensis)
Reptilia PCDH10 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh10 30
  • 74.91 (n)
zebrafish
(Danio rerio)
Actinopterygii pcdh10b 31 30
  • 76 (a)
OneToMany
pcdh10a 31 30
  • 73.37 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
ManyToMany
CSA.7308 31
  • 19 (a)
ManyToMany
Species where no ortholog for PCDH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH10 Gene

ENSEMBL:
Gene Tree for PCDH10 (if available)
TreeFam:
Gene Tree for PCDH10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCDH10: view image

Paralogs for PCDH10 Gene

genes like me logo Genes that share paralogs with PCDH10: view

Variants for PCDH10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCDH10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
713855 Likely Benign: not provided 133,163,110(+) C/G SYNONYMOUS_VARIANT
715498 Likely Benign: not provided 133,151,688(+) T/G SYNONYMOUS_VARIANT
729743 Likely Benign: not provided 133,151,118(+) G/A SYNONYMOUS_VARIANT
730296 Likely Benign: not provided 133,151,423(+) C/T MISSENSE_VARIANT
731715 Benign: not provided 133,150,710(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PCDH10 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDH10 Gene

Variant ID Type Subtype PubMed ID
esv274926 CNV gain+loss 21479260
esv3602276 CNV loss 21293372
nsv470078 CNV gain 18288195
nsv595466 CNV loss 21841781

Variation tolerance for PCDH10 Gene

Residual Variation Intolerance Score: 1.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCDH10 Gene

Human Gene Mutation Database (HGMD)
PCDH10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCDH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCDH10 Gene

Disorders for PCDH10 Gene

MalaCards: The human disease database

(21) MalaCards diseases for PCDH10 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PCDH10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PCDH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCDH10 Gene

Publications for PCDH10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers. (PMID: 20353276) Yu B … Zhang W (Neoplasma 2010) 3 23 54
  3. Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer. (PMID: 19084528) Yu J … Sung JJ (Gastroenterology 2009) 3 23 54
  4. Identifying autism loci and genes by tracing recent shared ancestry. (PMID: 18621663) Morrow EM … Walsh CA (Science (New York, N.Y.) 2008) 3 23 54
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q … Maniatis T (Genome research 2001) 3 4 54

Products for PCDH10 Gene

Sources for PCDH10 Gene