The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific inter... See more...

Aliases for PCBP2 Gene

Aliases for PCBP2 Gene

  • Poly(RC) Binding Protein 2 2 3 5
  • Poly(RC)-Binding Protein 2 2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein E2 3 4
  • Heterogenous Nuclear Ribonucleoprotein E2 2 3
  • Alpha-CP2 3 4
  • HnRNP-E2 2 3
  • HnRNP E2 3 4
  • HNRNPE2 2 3
  • HNRPE2 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • PCBP2 5

External Ids for PCBP2 Gene

Previous GeneCards Identifiers for PCBP2 Gene

  • GC12P053844
  • GC12P053960
  • GC12P053562
  • GC12P052132
  • GC12P050885

Summaries for PCBP2 Gene

Entrez Gene Summary for PCBP2 Gene

  • The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

GeneCards Summary for PCBP2 Gene

PCBP2 (Poly(RC) Binding Protein 2) is a Protein Coding gene. Diseases associated with PCBP2 include Semantic Dementia and Tremor, Hereditary Essential, 4. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP1.

UniProtKB/Swiss-Prot Summary for PCBP2 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
  • (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP2 Gene

Additional gene information for PCBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCBP2 Gene

Genomics for PCBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PCBP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCBP2

Top Transcription factor binding sites by QIAGEN in the PCBP2 gene promoter:
  • Bach2
  • E47
  • Elk-1
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • MIF-1
  • RORalpha1
  • Tal-1beta
  • TBP

Genomic Locations for PCBP2 Gene

Genomic Locations for PCBP2 Gene
chr12:53,452,102-53,481,162
(GRCh38/hg38)
Size:
29,061 bases
Orientation:
Plus strand
chr12:53,835,525-53,874,946
(GRCh37/hg19)
Size:
39,422 bases
Orientation:
Plus strand

Genomic View for PCBP2 Gene

Genes around PCBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP2 Gene

Proteins for PCBP2 Gene

  • Protein details for PCBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15366-PCBP2_HUMAN
    Recommended name:
    Poly(rC)-binding protein 2
    Protein Accession:
    Q15366
    Secondary Accessions:
    • A8K7X6
    • B4DXP5
    • F8VYL7
    • G3V0E8
    • I6L8F9
    • Q32Q82
    • Q59HD4
    • Q68Y55
    • Q6IPF4
    • Q6PKG5

    Protein attributes for PCBP2 Gene

    Size:
    365 amino acids
    Molecular mass:
    38580 Da
    Quaternary structure:
    • Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains).
    SequenceCaution:
    • Sequence=BAD92062.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP2 Gene

    Alternative splice isoforms for PCBP2 Gene

neXtProt entry for PCBP2 Gene

Post-translational modifications for PCBP2 Gene

  • Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • (Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.
  • Ubiquitination at Lys78, Lys115, Lys185, and Lys322
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCBP2 Gene

Domains & Families for PCBP2 Gene

Gene Families for PCBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PCBP2 Gene

InterPro:
Blocks:
  • KH domain
  • KH, type 1
ProtoNet:

Suggested Antigen Peptide Sequences for PCBP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77432, highly similar to Homo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 2, mRNA (A8K7X6_HUMAN)
  • cDNA FLJ58476, highly similar to Poly(rC)-binding protein 2 (B4DLC0_HUMAN)
  • cDNA FLJ54752, highly similar to Poly(rC)-binding protein 2 (B4DRD7_HUMAN)
  • cDNA FLJ58339, highly similar to Poly(rC)-binding protein 2 (B4DXP5_HUMAN)
  • Heterogeneous nuclear ribonucleoprotein E2 (PCBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15366

UniProtKB/Swiss-Prot:

PCBP2_HUMAN :
  • The KH domains mediates poly(C) binding.
Domain:
  • The KH domains mediates poly(C) binding.
genes like me logo Genes that share domains with PCBP2: view

Function for PCBP2 Gene

Molecular function for PCBP2 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
GENATLAS Biochemistry:
poly(rC)-binding protein 2,expressed in keratinocytes and other cells

Phenotypes From GWAS Catalog for PCBP2 Gene

Gene Ontology (GO) - Molecular Function for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IBA 21873635
GO:0003723 RNA binding IDA 7607214
GO:0003729 mRNA binding IBA 21873635
genes like me logo Genes that share ontologies with PCBP2: view
genes like me logo Genes that share phenotypes with PCBP2: view

Animal Models for PCBP2 Gene

MGI Knock Outs for PCBP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCBP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCBP2 Gene

Localization for PCBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP2 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 3
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 19029303
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with PCBP2: view

Pathways & Interactions for PCBP2 Gene

genes like me logo Genes that share pathways with PCBP2: view

Pathways by source for PCBP2 Gene

1 BioSystems pathway for PCBP2 Gene
1 KEGG pathway for PCBP2 Gene
2 Cell Signaling Technology pathways for PCBP2 Gene

SIGNOR curated interactions for PCBP2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002376 immune system process IEA --
GO:0010468 regulation of gene expression IBA 21873635
GO:0016032 viral process IEA --
GO:0016070 RNA metabolic process TAS --
genes like me logo Genes that share ontologies with PCBP2: view

Drugs & Compounds for PCBP2 Gene

(1) Drugs for PCBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP2: view

Transcripts for PCBP2 Gene

mRNA/cDNA for PCBP2 Gene

7 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCBP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: -
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for PCBP2 Gene

GeneLoc Exon Structure for
PCBP2

Expression for PCBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCBP2 Gene



Protein tissue co-expression partners for PCBP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCBP2

SOURCE GeneReport for Unigene cluster for PCBP2 Gene:

Hs.546271

mRNA Expression by UniProt/SwissProt for PCBP2 Gene:

Q15366-PCBP2_HUMAN
Tissue specificity: Detected in all tissues examined.

Evidence on tissue expression from TISSUES for PCBP2 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Lung(4.8)
  • Blood(4.8)
  • Eye(4.7)
  • Intestine(4)
  • Skin(3.5)
  • Kidney(3.2)
  • Bone marrow(3.1)
  • Muscle(3)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Heart(2.8)
  • Stomach(2.6)
  • Thyroid gland(2.6)
  • Adrenal gland(2.6)
  • Pancreas(2.6)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with PCBP2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCBP2 Gene

Orthologs for PCBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PCBP2 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
OneToMany
PCBP2 30
  • 98.81 (n)
-- 31
  • 98 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia PCBP2 30 31
  • 98.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pcbp2 30 17 31
  • 97.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pcbp2 30
  • 97.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
Chicken
(Gallus gallus)
Aves LOC426023 30
  • 89.77 (n)
PCBP2 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PCBP2 31
  • 98 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pcbp3 30
  • 77.97 (n)
Str.8469 30
Zebrafish
(Danio rerio)
Actinopterygii pcbp2 30
  • 77.15 (n)
PCBP2 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mub 32
  • 46 (a)
Species where no ortholog for PCBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PCBP2 Gene

ENSEMBL:
Gene Tree for PCBP2 (if available)
TreeFam:
Gene Tree for PCBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCBP2: view image

Paralogs for PCBP2 Gene

(14) SIMAP similar genes for PCBP2 Gene using alignment to 15 proteins:

  • PCBP2_HUMAN
  • B4DLC0_HUMAN
  • B4DXP5_HUMAN
  • F8VRH0_HUMAN
  • F8VTZ0_HUMAN
  • F8VXH9_HUMAN
  • F8VZX2_HUMAN
  • F8W0G4_HUMAN
  • F8W1G6_HUMAN
  • G3V0E8_HUMAN
  • H3BND9_HUMAN
  • H3BRU6_HUMAN
  • H3BSP4_HUMAN
  • H3BSS4_HUMAN
  • L8E745_HUMAN

Pseudogenes.org Pseudogenes for PCBP2 Gene

genes like me logo Genes that share paralogs with PCBP2: view

Variants for PCBP2 Gene

Additional dbSNP identifiers (rs#s) for PCBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCBP2 Gene

Variant ID Type Subtype PubMed ID
esv3629541 CNV loss 21293372
nsv714 CNV insertion 18451855

Variation tolerance for PCBP2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PCBP2 Gene

Disorders for PCBP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PCBP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
semantic dementia
  • semantic primary progressive aphasia
tremor, hereditary essential, 4
  • etm4
leukemia, chronic myeloid
  • cml
frontotemporal dementia
  • ftd
- elite association - COSMIC cancer census association via MalaCards
Search PCBP2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PCBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCBP2 Gene

Publications for PCBP2 Gene

  1. Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms. (PMID: 18701464) Du Z … James TL (The Journal of biological chemistry 2008) 3 4 23
  2. X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. (PMID: 17526645) Du Z … James TL (RNA (New York, N.Y.) 2007) 3 4 23
  3. Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A. (PMID: 8833161) Tommerup N … Leffers H (Genomics 1996) 2 3 23
  4. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. (PMID: 24371074) Chase AJ … Semler BL (Journal of virology 2014) 3 4
  5. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. (PMID: 20211135) Eiring AM … Perrotti D (Cell 2010) 3 23

Products for PCBP2 Gene