The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific inter... See more...

Aliases for PCBP2 Gene

Aliases for PCBP2 Gene

  • Poly(RC) Binding Protein 2 2 3 5
  • Poly(RC)-Binding Protein 2 2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein E2 3 4
  • Heterogenous Nuclear Ribonucleoprotein E2 2 3
  • Alpha-CP2 3 4
  • HnRNP E2 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • HnRNP-E2 3
  • HNRNPE2 3
  • HNRPE2 3

External Ids for PCBP2 Gene

Previous GeneCards Identifiers for PCBP2 Gene

  • GC12P053844
  • GC12P053960
  • GC12P053562
  • GC12P052132
  • GC12P050885

Summaries for PCBP2 Gene

Entrez Gene Summary for PCBP2 Gene

  • The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

GeneCards Summary for PCBP2 Gene

PCBP2 (Poly(RC) Binding Protein 2) is a Protein Coding gene. Diseases associated with PCBP2 include Semantic Dementia and Leukemia, Chronic Myeloid. Among its related pathways are Gene Expression and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP1.

UniProtKB/Swiss-Prot Summary for PCBP2 Gene

  • Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
  • (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).

Gene Wiki entry for PCBP2 Gene

Additional gene information for PCBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PCBP2 Gene

Genomics for PCBP2 Gene

GeneHancer (GH) Regulatory Elements for PCBP2 Gene

Promoters and enhancers for PCBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053452 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 524.1 +1.0 999 3.8 RXRA FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 PCBP2 AAAS TARBP2 NPFF ZNF740 C12orf10 MAP3K12 PRR13 HNRNPA1 CBX5
GH12J053440 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -9.5 -9518 4.7 ZNF217 SIN3A USF1 POLR2G SP1 NCOR1 GTF2E2 PHF8 ZBTB5 POLR2A PRR13 ENSG00000257379 lnc-MAP3K12-4 PCBP2 SP1 AAAS
GH12J053971 Promoter/Enhancer 2.7 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 48.1 +551.2 551210 63 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 POLR2G USF1 NCOR1 HOXC8 HOXC4 HOXC11 HOXC9 HOXC6 HOXC10 HOXC5 HNRNPA1 ATF7 ZNF740
GH12J052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 48.9 -549.2 -549174 16.1 LARP7 EP300 HNRNPK ZNF217 CTCF ZSCAN5C TCF12 NRF1 POLR2G USF1 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 CSAD EIF4B ENSG00000257550 TARBP2
GH12J053179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 54.1 -270.4 -270384 4.8 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G ZNF740 CSAD PCBP2 ATF7 ENSG00000257550 SP1 AAAS EIF4B SOAT2 CALCOCO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCBP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PCBP2

Top Transcription factor binding sites by QIAGEN in the PCBP2 gene promoter:
  • Bach2
  • E47
  • Elk-1
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • MIF-1
  • RORalpha1
  • Tal-1beta
  • TBP

Genomic Locations for PCBP2 Gene

Genomic Locations for PCBP2 Gene
chr12:53,452,102-53,481,162
(GRCh38/hg38)
Size:
29,061 bases
Orientation:
Plus strand
chr12:53,835,525-53,874,946
(GRCh37/hg19)
Size:
39,422 bases
Orientation:
Plus strand

Genomic View for PCBP2 Gene

Genes around PCBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCBP2 Gene

Proteins for PCBP2 Gene

  • Protein details for PCBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15366-PCBP2_HUMAN
    Recommended name:
    Poly(rC)-binding protein 2
    Protein Accession:
    Q15366
    Secondary Accessions:
    • A8K7X6
    • B4DXP5
    • F8VYL7
    • G3V0E8
    • I6L8F9
    • Q32Q82
    • Q59HD4
    • Q68Y55
    • Q6IPF4
    • Q6PKG5

    Protein attributes for PCBP2 Gene

    Size:
    365 amino acids
    Molecular mass:
    38580 Da
    Quaternary structure:
    • Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains).
    SequenceCaution:
    • Sequence=BAD92062.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCBP2 Gene

    Alternative splice isoforms for PCBP2 Gene

neXtProt entry for PCBP2 Gene

Post-translational modifications for PCBP2 Gene

  • Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • (Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.
  • Ubiquitination at Lys78, Lys115, Lys185, and Lys322
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCBP2 Gene

Domains & Families for PCBP2 Gene

Gene Families for PCBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PCBP2 Gene

Blocks:
  • KH domain
  • KH, type 1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCBP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77432, highly similar to Homo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 2, mRNA (A8K7X6_HUMAN)
  • cDNA FLJ58476, highly similar to Poly(rC)-binding protein 2 (B4DLC0_HUMAN)
  • cDNA FLJ54752, highly similar to Poly(rC)-binding protein 2 (B4DRD7_HUMAN)
  • cDNA FLJ58339, highly similar to Poly(rC)-binding protein 2 (B4DXP5_HUMAN)
  • Heterogeneous nuclear ribonucleoprotein E2 (PCBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15366

UniProtKB/Swiss-Prot:

PCBP2_HUMAN :
  • The KH domains mediates poly(C) binding.
Domain:
  • The KH domains mediates poly(C) binding.
genes like me logo Genes that share domains with PCBP2: view

Function for PCBP2 Gene

Molecular function for PCBP2 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
GENATLAS Biochemistry:
poly(rC)-binding protein 2,expressed in keratinocytes and other cells

Phenotypes From GWAS Catalog for PCBP2 Gene

Gene Ontology (GO) - Molecular Function for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 7607214
GO:0005515 protein binding IPI 16713569
GO:0019899 enzyme binding IPI 19881509
genes like me logo Genes that share ontologies with PCBP2: view
genes like me logo Genes that share phenotypes with PCBP2: view

Animal Models for PCBP2 Gene

MGI Knock Outs for PCBP2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCBP2 Gene

Localization for PCBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCBP2 Gene

Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCBP2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
mitochondrion 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 19029303
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with PCBP2: view

Pathways & Interactions for PCBP2 Gene

genes like me logo Genes that share pathways with PCBP2: view

Pathways by source for PCBP2 Gene

1 BioSystems pathway for PCBP2 Gene
1 KEGG pathway for PCBP2 Gene
2 Cell Signaling Technology pathways for PCBP2 Gene

Gene Ontology (GO) - Biological Process for PCBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002376 immune system process IEA --
GO:0016070 RNA metabolic process TAS --
GO:0016071 mRNA metabolic process NAS 7556077
GO:0032480 negative regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with PCBP2: view

No data available for SIGNOR curated interactions for PCBP2 Gene

Drugs & Compounds for PCBP2 Gene

(1) Drugs for PCBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PCBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCBP2: view

Transcripts for PCBP2 Gene

mRNA/cDNA for PCBP2 Gene

7 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: -
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for PCBP2 Gene

GeneLoc Exon Structure for
PCBP2

Expression for PCBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCBP2 Gene



Protein tissue co-expression partners for PCBP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PCBP2

SOURCE GeneReport for Unigene cluster for PCBP2 Gene:

Hs.546271

mRNA Expression by UniProt/SwissProt for PCBP2 Gene:

Q15366-PCBP2_HUMAN
Tissue specificity: Detected in all tissues examined.

Evidence on tissue expression from TISSUES for PCBP2 Gene

  • Liver(4.8)
  • Lung(4.8)
  • Nervous system(4.8)
  • Eye(4.7)
  • Blood(3.7)
  • Intestine(3.6)
  • Skin(2.7)
  • Bone marrow(2.4)
  • Kidney(2.3)
  • Lymph node(2.3)
  • Thyroid gland(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Muscle(2.2)
  • Spleen(2.2)
  • Stomach(2.2)
  • Heart(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PCBP2: view