Aliases for PBXIP1 Gene
External Ids for PBXIP1 Gene
Previous GeneCards Identifiers for PBXIP1 Gene
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
GeneCards Summary for PBXIP1 Gene
PBXIP1 (PBX Homeobox Interacting Protein 1) is a Protein Coding gene. Diseases associated with PBXIP1 include Leukemia and Pediatric Ependymoma. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity.
UniProtKB/Swiss-Prot Summary for PBXIP1 Gene
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.