This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011] See more...

Aliases for PBOV1 Gene

Aliases for PBOV1 Gene

  • Prostate And Breast Cancer Overexpressed 1 2 3 5
  • UROC28 2 3 4
  • UC28 2 3 4
  • Prostate And Breast Cancer Overexpressed Gene 1 Protein 3 4
  • Protein UROC28 4
  • DJ171N11.2 3
  • PBOV1 5

External Ids for PBOV1 Gene

Previous GeneCards Identifiers for PBOV1 Gene

  • GC06M138472
  • GC06M138517
  • GC06M138578

Summaries for PBOV1 Gene

Entrez Gene Summary for PBOV1 Gene

  • This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011]

GeneCards Summary for PBOV1 Gene

PBOV1 (Prostate And Breast Cancer Overexpressed 1) is a Protein Coding gene. Diseases associated with PBOV1 include Granular Cell Carcinoma and Papillary Transitional Carcinoma.

Additional gene information for PBOV1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PBOV1 Gene

Genomics for PBOV1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PBOV1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J138219 Enhancer 0.6 dbSUPER 600.7 -1.6 -1624 0.5 GATAD2A ATF7 RCOR2 RXRB CEBPA SOX13 SMAD4 CEBPB NFIL3 RARA PBOV1 RF00017-5806 ARFGEF3 SMIM28
GH06J138220 Enhancer 0.2 dbSUPER 600.7 -1.0 -975 0.7 PBOV1 ARFGEF3 RF00017-5806 SMIM28
GH06J137970 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 19.7 +248.0 248023 0.3 JUND NR2C1 ETV6 MGA HMBOX1 TARDBP NFE2 NR2C2 GABPA MYC PBOV1 LOC107986545 LINC02528 LINC02865 TNFAIP3 PERP
GH06J138257 Enhancer 0.9 ENCODE dbSUPER 10.9 -40.0 -40041 2.2 GATAD2A RCOR2 FOXA1 RXRB IRF2 GABPA CEBPA SOX13 RFX3 TCF7 PBOV1 ARFGEF3 RF00017-5807 RF00017-5806 SMIM28
GH06J138182 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.9 +35.4 35390 2.2 USF1 ZNF189 SP1 CHD2 PBOV1 PERP ARFGEF3 RF00017-5805
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PBOV1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PBOV1

Top Transcription factor binding sites by QIAGEN in the PBOV1 gene promoter:
  • AML1a
  • GATA-1
  • HEN1
  • Lhx3a
  • LHX3b
  • NF-AT3
  • NF-AT4
  • Pbx1a

Genomic Locations for PBOV1 Gene

Genomic Locations for PBOV1 Gene
chr6:138,215,986-138,218,491
(GRCh38/hg38)
Size:
2,506 bases
Orientation:
Minus strand
chr6:138,537,123-138,539,627
(GRCh37/hg19)
Size:
2,505 bases
Orientation:
Minus strand

Genomic View for PBOV1 Gene

Genes around PBOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBOV1 Gene

Proteins for PBOV1 Gene

  • Protein details for PBOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY1-PBOV1_HUMAN
    Recommended name:
    Prostate and breast cancer overexpressed gene 1 protein
    Protein Accession:
    Q9GZY1

    Protein attributes for PBOV1 Gene

    Size:
    135 amino acids
    Molecular mass:
    15722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PBOV1 Gene

Post-translational modifications for PBOV1 Gene

No Post-translational modifications

Other Protein References for PBOV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBOV1 Gene

Domains & Families for PBOV1 Gene

Gene Families for PBOV1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PBOV1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PBOV1 Gene

GenScript: Design optimal peptide antigens:
  • Protein UROC28 (PBOV1_HUMAN)
genes like me logo Genes that share domains with PBOV1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PBOV1 Gene

Function for PBOV1 Gene

genes like me logo Genes that share phenotypes with PBOV1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PBOV1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PBOV1 Gene

Localization for PBOV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBOV1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PBOV1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PBOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PBOV1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PBOV1 Gene

Pathways & Interactions for PBOV1 Gene

PathCards logo

SuperPathways for PBOV1 Gene

No Data Available

Interacting Proteins for PBOV1 Gene

Gene Ontology (GO) - Biological Process for PBOV1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PBOV1 Gene

Drugs & Compounds for PBOV1 Gene

No Compound Related Data Available

Transcripts for PBOV1 Gene

mRNA/cDNA for PBOV1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PBOV1

Alternative Splicing Database (ASD) splice patterns (SP) for PBOV1 Gene

No ASD Table

Relevant External Links for PBOV1 Gene

GeneLoc Exon Structure for
PBOV1

Expression for PBOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PBOV1 Gene

mRNA differential expression in normal tissues according to GTEx for PBOV1 Gene

This gene is overexpressed in Brain - Cerebellum (x10.4) and Brain - Cerebellar Hemisphere (x5.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PBOV1

SOURCE GeneReport for Unigene cluster for PBOV1 Gene:

Hs.302016

mRNA Expression by UniProt/SwissProt for PBOV1 Gene:

Q9GZY1-PBOV1_HUMAN
Tissue specificity: Expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary, and peripheral blood leukocytes. Up-regulated expression in prostate, breast, and bladder cancer, but not in lung and colon cancer.
genes like me logo Genes that share expression patterns with PBOV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PBOV1 Gene

Orthologs for PBOV1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PBOV1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PBOV1 30
  • 99.75 (n)
Species where no ortholog for PBOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PBOV1 Gene

ENSEMBL:
Gene Tree for PBOV1 (if available)
TreeFam:
Gene Tree for PBOV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PBOV1: view image

Paralogs for PBOV1 Gene

No data available for Paralogs for PBOV1 Gene

Variants for PBOV1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PBOV1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs6927706 - p.Ile73Thr

Additional dbSNP identifiers (rs#s) for PBOV1 Gene

Variation tolerance for PBOV1 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PBOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PBOV1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PBOV1 Gene

Disorders for PBOV1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PBOV1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
granular cell carcinoma
  • granular cell adenocarcinoma
papillary transitional carcinoma
  • papillary transitional cell carcinoma
testis seminoma
  • seminoma
bladder cancer
  • bladder cancer, somatic
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PBOV1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PBOV1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PBOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBOV1 Gene

Publications for PBOV1 Gene

  1. Enhanced expression of the UROC28 gene in human breast cancer: relationship to ERBB2 gene expression. (PMID: 12553037) Kamagata C … Watanabe N (Anticancer research 2002) 2 3 23
  2. Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers. (PMID: 11156405) An G … Veltri RW (Cancer research 2000) 2 3 4
  3. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou MA … Kyriacou K (Breast cancer research and treatment 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for PBOV1 Gene

Sources for PBOV1 Gene