Aliases for PBK Gene
External Ids for PBK Gene
Previous GeneCards Identifiers for PBK Gene
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PBK Gene
PBK (PDZ Binding Kinase) is a Protein Coding gene. Diseases associated with PBK include Plexiform Neurofibroma and Central Corneal Ulcer. Among its related pathways are DNA Damage and 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot Summary for PBK Gene
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.