Aliases for PAXBP1 Gene
External Ids for PAXBP1 Gene
Previous HGNC Symbols for PAXBP1 Gene
Previous GeneCards Identifiers for PAXBP1 Gene
This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]
GeneCards Summary for PAXBP1 Gene
PAXBP1 (PAX3 And PAX7 Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is GCFC2.
UniProtKB/Swiss-Prot Summary for PAXBP1 Gene
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).