Aliases for PAX7 Gene
External Ids for PAX7 Gene
Previous GeneCards Identifiers for PAX7 Gene
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for PAX7 Gene
PAX7 (Paired Box 7) is a Protein Coding gene. Diseases associated with PAX7 include Rhabdomyosarcoma 2 and Embryonal Rhabdomyosarcoma. Among its related pathways are Transcriptional misregulation in cancer and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is PAX3.
UniProtKB/Swiss-Prot Summary for PAX7 Gene
Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.