Aliases for PAX7 Gene
External Ids for PAX7 Gene
Previous GeneCards Identifiers for PAX7 Gene
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for PAX7 Gene
PAX7 (Paired Box 7) is a Protein Coding gene. Diseases associated with PAX7 include Myopathy, Congenital, Progressive, With Scoliosis and Rhabdomyosarcoma 2. Among its related pathways are Transcriptional misregulation in cancer and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is PAX3.
UniProtKB/Swiss-Prot Summary for PAX7 Gene
Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.