Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PAWR Gene

Aliases for PAWR Gene

  • Pro-Apoptotic WT1 Regulator 2 3 5
  • PRKC, Apoptosis, WT1, Regulator 2 3
  • Prostate Apoptosis Response-4 2 3
  • PAR-4 3 4
  • PAR4 3 4
  • Prostate Apoptosis Response Protein PAR-4 3
  • Prostate Apoptosis Response Protein 4 3
  • Prostate Apoptosis Response 4 Protein 4
  • PRKC Apoptosis WT1 Regulator Protein 3
  • Transcriptional Repressor PAR4 3
  • WT1-Interacting Protein 3

External Ids for PAWR Gene

Previous GeneCards Identifiers for PAWR Gene

  • GC12M079960
  • GC12M080349
  • GC12M078488
  • GC12M077042

Summaries for PAWR Gene

Entrez Gene Summary for PAWR Gene

  • This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

GeneCards Summary for PAWR Gene

PAWR (Pro-Apoptotic WT1 Regulator) is a Protein Coding gene. Diseases associated with PAWR include Prostate Cancer and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Coregulation of Androgen receptor activity and Ceramide signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for PAWR Gene

  • Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Gene Wiki entry for PAWR Gene

Additional gene information for PAWR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAWR Gene

Genomics for PAWR Gene

GeneHancer (GH) Regulatory Elements for PAWR Gene

Promoters and enhancers for PAWR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I079684 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.9 1932 9.2 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF213 LOC105369864 PAWR ENSG00000258044 ENSG00000257894 NOP56P3
GH12I079545 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +142.7 142696 5.8 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ETS1 PAWR ENSG00000258044 ENSG00000257894 ENSG00000257474 NOP56P3
GH12I079557 Enhancer 1.1 Ensembl ENCODE 16 +132.0 131958 3.9 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 RARA ETS1 YY1 CREM NOP56P3 PAWR ENSG00000258044 ENSG00000257894 LOC105369864
GH12I079407 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.3 +281.8 281771 3 CTCF PKNOX1 MZF1 RAD21 RFX5 RELA ZNF335 GATA3 ZNF143 SMC3 PAWR ENSG00000258044 MIR1252 ENSG00000257894 LOC100420794 SYT1
GH12I079565 Enhancer 1 Ensembl ENCODE 10.9 +124.3 124274 1.9 ELF3 FOXA2 MLX RAD21 RARA YY1 SLC30A9 CREM MIXL1 MXD4 PAWR ENSG00000258044 NOP56P3 LOC105369864
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PAWR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAWR gene promoter:

Genomic Locations for PAWR Gene

Genomic Locations for PAWR Gene
chr12:79,574,979-79,691,097
(GRCh38/hg38)
Size:
116,119 bases
Orientation:
Minus strand
chr12:79,968,759-80,084,877
(GRCh37/hg19)

Genomic View for PAWR Gene

Genes around PAWR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAWR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAWR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAWR Gene

Proteins for PAWR Gene

  • Protein details for PAWR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ0-PAWR_HUMAN
    Recommended name:
    PRKC apoptosis WT1 regulator protein
    Protein Accession:
    Q96IZ0
    Secondary Accessions:
    • O75796
    • Q6FHY9
    • Q8N700

    Protein attributes for PAWR Gene

    Size:
    340 amino acids
    Molecular mass:
    36568 Da
    Quaternary structure:
    • Homooligomer. Interacts (via the C-terminal region) with WT1 (PubMed:8943350). Interacts with THAP1 (PubMed:12717420). Interacts with AATF (PubMed:14627703). Interacts with BACE1 (PubMed:15671026). Interacts with SPSB1 (via B30.2/SPRY domain); this interaction is direct and occurs in association with the Elongin BC complex (PubMed:17189197, PubMed:20561531). Interacts with SPSB2 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex (PubMed:17189197, PubMed:20561531). Interacts with SPSB4 (via B30.2/SPRY domain) (PubMed:20561531); this interaction occurs in association with the Elongin BC complex (PubMed:20561531). Component of a ternary complex composed of SQSTM1 and PRKCZ (PubMed:11755531). Interacts with actin (By similarity).

    Three dimensional structures from OCA and Proteopedia for PAWR Gene

neXtProt entry for PAWR Gene

Post-translational modifications for PAWR Gene

No data available for DME Specific Peptides for PAWR Gene

Domains & Families for PAWR Gene

Gene Families for PAWR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PAWR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PAWR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IZ0

UniProtKB/Swiss-Prot:

PAWR_HUMAN :
  • The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
Domain:
  • The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
  • The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity).
  • The B30.2/SPRY domain-binding motif mediates recognition by proteins containing a B30.2/SPRY domain.
genes like me logo Genes that share domains with PAWR: view

Function for PAWR Gene

Molecular function for PAWR Gene

GENATLAS Biochemistry:
PKC apoptosis WT1 regulator,prostate apoptosis reponse par-4,widely expressed
UniProtKB/Swiss-Prot Function:
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
UniProtKB/Swiss-Prot Induction:
By apoptosis.

Phenotypes From GWAS Catalog for PAWR Gene

Gene Ontology (GO) - Molecular Function for PAWR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 8943350
GO:0003779 actin binding ISS --
GO:0005515 protein binding IPI 11755531
GO:0019899 enzyme binding IDA 15671026
GO:0043522 leucine zipper domain binding IPI 14627703
genes like me logo Genes that share ontologies with PAWR: view
genes like me logo Genes that share phenotypes with PAWR: view

Animal Models for PAWR Gene

MGI Knock Outs for PAWR:

Animal Model Products

miRNA for PAWR Gene

miRTarBase miRNAs that target PAWR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PAWR Gene

Localization for PAWR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAWR Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAWR gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PAWR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus TAS,IDA 14627703
GO:0005737 cytoplasm IDA,TAS 14627703
GO:0005884 colocalizes_with actin filament ISS,IBA --
genes like me logo Genes that share ontologies with PAWR: view

Pathways & Interactions for PAWR Gene

genes like me logo Genes that share pathways with PAWR: view

Pathways by source for PAWR Gene

2 Cell Signaling Technology pathways for PAWR Gene

Gene Ontology (GO) - Biological Process for PAWR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA,ISS --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PAWR: view

No data available for SIGNOR curated interactions for PAWR Gene

Drugs & Compounds for PAWR Gene

(8) Drugs for PAWR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PAWR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PAWR: view

Transcripts for PAWR Gene

Unigene Clusters for PAWR Gene

PRKC, apoptosis, WT1, regulator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAWR Gene

No ASD Table

Relevant External Links for PAWR Gene

GeneLoc Exon Structure for
PAWR
ECgene alternative splicing isoforms for
PAWR

Expression for PAWR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAWR Gene

Protein differential expression in normal tissues from HIPED for PAWR Gene

This gene is overexpressed in Amniocyte (13.5), Bone marrow stromal cell (13.0), and Prostate (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAWR Gene



NURSA nuclear receptor signaling pathways regulating expression of PAWR Gene:

PAWR

SOURCE GeneReport for Unigene cluster for PAWR Gene:

Hs.643130

mRNA Expression by UniProt/SwissProt for PAWR Gene:

Q96IZ0-PAWR_HUMAN
Tissue specificity: Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.

Evidence on tissue expression from TISSUES for PAWR Gene

  • Kidney(4.3)
  • Liver(4.3)
  • Blood(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with PAWR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAWR Gene

Orthologs for PAWR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PAWR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAWR 33 34
  • 99.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PAWR 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAWR 33 34
  • 90.78 (n)
cow
(Bos Taurus)
Mammalia PAWR 33 34
  • 87.04 (n)
mouse
(Mus musculus)
Mammalia Pawr 33 16 34
  • 80.62 (n)
rat
(Rattus norvegicus)
Mammalia Pawr 33
  • 79.25 (n)
oppossum
(Monodelphis domestica)
Mammalia PAWR 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAWR 33 34
  • 74.51 (n)
lizard
(Anolis carolinensis)
Reptilia PAWR 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pawr 33
  • 67.16 (n)
zebrafish
(Danio rerio)
Actinopterygii pawr 33 34
  • 59.26 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3107 33
Species where no ortholog for PAWR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PAWR Gene

ENSEMBL:
Gene Tree for PAWR (if available)
TreeFam:
Gene Tree for PAWR (if available)

Paralogs for PAWR Gene

genes like me logo Genes that share paralogs with PAWR: view

No data available for Paralogs for PAWR Gene

Variants for PAWR Gene

Sequence variations from dbSNP and Humsavar for PAWR Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000013756 -- 79,666,324(-) G/C genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000045571 -- 79,687,809(-) A/T intron_variant
rs1000084046 -- 79,603,202(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000089507 -- 79,598,568(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000110527 -- 79,620,912(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAWR Gene

Variant ID Type Subtype PubMed ID
nsv476592 CNV novel sequence insertion 20440878
nsv1043290 CNV loss 25217958
esv3549463 CNV deletion 23714750
esv3344325 CNV insertion 20981092
esv3307239 CNV mobile element insertion 20981092

Variation tolerance for PAWR Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAWR Gene

Human Gene Mutation Database (HGMD)
PAWR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAWR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAWR Gene

Disorders for PAWR Gene

MalaCards: The human disease database

(2) MalaCards diseases for PAWR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search PAWR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PAWR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PAWR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAWR Gene

Publications for PAWR Gene

  1. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. (PMID: 8943350) Johnstone RW … Shi Y (Molecular and cellular biology 1996) 2 3 4 22 58
  2. Association of missense variants of the PRKC, apoptosis, WT1, regulator (PAWR) gene with schizophrenia. (PMID: 18281137) Wang LH … Chen CH (Progress in neuro-psychopharmacology & biological psychiatry 2008) 3 22 44 58
  3. No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. (PMID: 16969273) Weller AE … Berrettini WH (Psychiatric genetics 2006) 3 22 44 58
  4. PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. (PMID: 15671026) Xie J … Guo Q (The Journal of biological chemistry 2005) 3 4 22 58
  5. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PMID: 14627703) Guo Q … Xie J (The Journal of biological chemistry 2004) 3 4 22 58

Products for PAWR Gene

Sources for PAWR Gene

Content
Loading form....