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Aliases for PAUPAR Gene

Subcategory (RNA class) for PAUPAR Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for PAUPAR Gene

  • PAX6 Upstream Antisense RNA 2 3 5

External Ids for PAUPAR Gene

Previous GeneCards Identifiers for PAUPAR Gene

  • GC00U936036
  • GC11U902383
  • GC11P031826
  • GC11P031825
  • GC11P031820
  • GC11P031822

Summaries for PAUPAR Gene

Entrez Gene Summary for PAUPAR Gene

  • This gene is thought to produce a functional long non-coding RNA. Knockdown of this transcript results in genome-wide changes in gene expression, particularly of cell cyle genes, indicating a role in regulating differentiation. This transcript may bind to the promoter region of target genes and may also interact with the transcription factor Pax6 (paired box 6). [provided by RefSeq, Feb 2015]

GeneCards Summary for PAUPAR Gene

PAUPAR (PAX6 Upstream Antisense RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PAUPAR include Melanoma, Uveal and Neuroblastoma 1.

Additional gene information for PAUPAR Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAUPAR Gene

Genomics for PAUPAR Gene

GeneHancer (GH) Regulatory Elements for PAUPAR Gene

Promoters and enhancers for PAUPAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J031809 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.9 -940 5.7 SP1 ZFX CC2D1A ZNF148 ZSCAN21 SP7 PRDM1 EGR1 CREB1 GLIS2 PAX6-AS1 PAUPAR ENSG00000285283 PAX6 GC11P031784
GH11J031815 Promoter/Enhancer 1.3 Ensembl dbSUPER 0.7 +3.9 3894 0.8 ZFX SP7 PRDM1 PKNOX1 ZBTB8A ZIC2 ZEB2 ZNF629 ZNF692 ZNF341 GC11P031828 PAX6 ENSG00000285283 PAUPAR PAX6-AS1
GH11J031817 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 0.4 +5.2 5194 1.4 SP7 CREB1 ZBTB8A ZNF600 POLR2A ZNF629 ZNF561 SP2 ZBTB20 EZH2 GC11P031823 GC11P031828 PAX6 ENSG00000285283 PAUPAR PAX6-AS1
GH11J031803 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.4 -8.4 -8405 1 SP1 REST POLR2A NFE2 IKZF1 PAX6 PAX6-AS1 PAUPAR GC11P031784
GH11J031794 Enhancer 1.4 VISTA UCNEbase Ensembl dbSUPER 0.4 -17.2 -17170 3.5 MAFK ZNF316 USF1 PAX6 RCN1 DCDC1 GC11P031784 PAUPAR PAX6-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAUPAR on UCSC Golden Path with GeneCards custom track

Genomic Locations for PAUPAR Gene

Genomic Locations for PAUPAR Gene
chr11:31,812,307-32,002,405
(GRCh38/hg38)
Size:
190,099 bases
Orientation:
Plus strand

Genomic View for PAUPAR Gene

Genes around PAUPAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAUPAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAUPAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAUPAR Gene

Proteins for PAUPAR Gene

Post-translational modifications for PAUPAR Gene

No Post-translational modifications

No data available for DME Specific Peptides for PAUPAR Gene

Domains & Families for PAUPAR Gene

Gene Families for PAUPAR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PAUPAR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PAUPAR Gene

Function for PAUPAR Gene

Phenotypes From GWAS Catalog for PAUPAR Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAUPAR Gene

Localization for PAUPAR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PAUPAR Gene

Pathways & Interactions for PAUPAR Gene

PathCards logo

SuperPathways for PAUPAR Gene

No Data Available

Interacting Proteins for PAUPAR Gene

Gene Ontology (GO) - Biological Process for PAUPAR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAUPAR Gene

Drugs & Compounds for PAUPAR Gene

No Compound Related Data Available

Transcripts for PAUPAR Gene

mRNA/cDNA for PAUPAR Gene

(1) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(1) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for PAUPAR Gene

No ASD Table

Relevant External Links for PAUPAR Gene

GeneLoc Exon Structure for
PAUPAR
ECgene alternative splicing isoforms for
PAUPAR

Expression for PAUPAR Gene

NURSA nuclear receptor signaling pathways regulating expression of PAUPAR Gene:

PAUPAR
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAUPAR Gene

Orthologs for PAUPAR Gene

Evolution for PAUPAR Gene

ENSEMBL:
Gene Tree for PAUPAR (if available)
TreeFam:
Gene Tree for PAUPAR (if available)

No data available for Orthologs for PAUPAR Gene

Paralogs for PAUPAR Gene

No data available for Paralogs for PAUPAR Gene

Variants for PAUPAR Gene

Sequence variations from dbSNP and Humsavar for PAUPAR Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000079323 -- 31,824,966(+) A/C upstream_transcript_variant
rs1000300934 -- 31,824,693(+) GGGG/GGGGGG upstream_transcript_variant
rs1000856606 -- 31,825,913(+) A/G upstream_transcript_variant
rs1000865861 -- 31,829,780(+) G/A downstream_transcript_variant
rs1001650738 -- 31,828,691(+) C/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PAUPAR Gene

Variant ID Type Subtype PubMed ID
esv3625840 CNV gain 21293372
nsv7728 CNV deletion 18451855
nsv825815 CNV gain 20364138

Additional Variant Information for PAUPAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAUPAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PAUPAR Gene

Disorders for PAUPAR Gene

MalaCards: The human disease database

(3) MalaCards diseases for PAUPAR Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
melanoma, uveal
  • uveal melanoma
neuroblastoma 1
  • neuroblastoma, susceptibility to, 1
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PAUPAR

genes like me logo Genes that share disorders with PAUPAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAUPAR Gene

Publications for PAUPAR Gene

  1. The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis. (PMID: 29661885) Pavlaki I … Vance KW (The EMBO journal 2018) 2 3 58
  2. The long non-coding RNA Paupar regulates the expression of both local and distal genes. (PMID: 24488179) Vance KW … Ponting CP (The EMBO journal 2014) 2 3 58
  3. PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma. (PMID: 27214741) Ding X … Li J (FEBS letters 2016) 3 58

Products for PAUPAR Gene

Sources for PAUPAR Gene

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