This gene is thought to produce a functional long non-coding RNA. Knockdown of this transcript results in genome-wide changes in gene expression, particularly of cell cyle genes, indicating a role in regulating differentiation. This transcript may bind to the promoter region of target genes and may also interact with the transcription factor Pax6 (paired box 6). [provided by Re... See more...

Aliases for PAUPAR Gene

Subcategory (RNA class) for PAUPAR Gene

lncRNA

Number of RNA Genes sources:

4 / 17

Aliases for PAUPAR Gene

  • PAX6 Upstream Antisense RNA 2 3 5
  • PAUPAR 2 5 165
  • NONHSAG007973.2 91
  • NONHSAG007975.2 91
  • HSALNG0083445 164
  • HSALNG0083446 164
  • HSALNG0083447 164
  • Lnc-ELP4-12 165
  • Lnc-RCN1-5 165

External Ids for PAUPAR Gene

Previous GeneCards Identifiers for PAUPAR Gene

  • GC00U936036
  • GC11U902383
  • GC11P031826
  • GC11P031825
  • GC11P031827
  • GC11P031822

Summaries for PAUPAR Gene

Entrez Gene Summary for PAUPAR Gene

  • This gene is thought to produce a functional long non-coding RNA. Knockdown of this transcript results in genome-wide changes in gene expression, particularly of cell cyle genes, indicating a role in regulating differentiation. This transcript may bind to the promoter region of target genes and may also interact with the transcription factor Pax6 (paired box 6). [provided by RefSeq, Feb 2015]

GeneCards Summary for PAUPAR Gene

PAUPAR (PAX6 Upstream Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with PAUPAR include Melanoma, Uveal and Neuroblastoma.

Additional gene information for PAUPAR Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAUPAR Gene

Genomics for PAUPAR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PAUPAR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAUPAR on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for PAUPAR Gene

Genomic Locations for PAUPAR Gene
chr11:31,812,307-32,002,405
(GRCh38/hg38)
Size:
190,099 bases
Orientation:
Plus strand

Genomic View for PAUPAR Gene

Genes around PAUPAR on UCSC Golden Path with GeneCards custom track
PAUPAR in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
PAUPAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAUPAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAUPAR Gene

Proteins for PAUPAR Gene

Post-translational modifications for PAUPAR Gene

No Post-translational modifications

No data available for DME Specific Peptides for PAUPAR Gene

Domains & Families for PAUPAR Gene

Gene Families for PAUPAR Gene

genes like me logo Genes that share domains with PAUPAR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PAUPAR Gene

Function for PAUPAR Gene

Phenotypes From GWAS Catalog for PAUPAR Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAUPAR Gene

Localization for PAUPAR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAUPAR gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PAUPAR Gene

Pathways & Interactions for PAUPAR Gene

PathCards logo

SuperPathways for PAUPAR Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAUPAR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for PAUPAR Gene

Drugs & Compounds for PAUPAR Gene

No Compound Related Data Available

Transcripts for PAUPAR Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for PAUPAR Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000732D2A_9606 lncRNA 2737 3

HGNC: 49670,

RefSeq: NR_117094,

ENA: KJ434992.1:1..2754:ncRNA,

URS0000811F73_9606 lncRNA 2965 2

Ensembl: ENST00000630360 (view in UCSC) ,

LNCipedia: PAUPAR:13,

URS0000D6305B_9606 lncRNA 2071 2

Ensembl: ENST00000643826 (view in UCSC) ,

LNCipedia: PAUPAR:12,

URS0000D63EF9_9606 lncRNA 1996 2

Ensembl: ENST00000642549 (view in UCSC) ,

LNCipedia: PAUPAR:14,

URS0000D65193_9606 lncRNA 1888 2

Ensembl: ENST00000647350 (view in UCSC) ,

LNCipedia: PAUPAR:11,

PAUPAR in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for PAUPAR Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for PAUPAR Gene

No ASD Table

Relevant External Links for PAUPAR Gene

GeneLoc Exon Structure for
PAUPAR

Expression for PAUPAR Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAUPAR Gene

Orthologs for PAUPAR Gene

Evolution for PAUPAR Gene

ENSEMBL:
Gene Tree for PAUPAR (if available)
TreeFam:
Gene Tree for PAUPAR (if available)

No data available for Orthologs for PAUPAR Gene

Paralogs for PAUPAR Gene

No data available for Paralogs for PAUPAR Gene

Variants for PAUPAR Gene

Additional dbSNP identifiers (rs#s) for PAUPAR Gene

Structural Variations from Database of Genomic Variants (DGV) for PAUPAR Gene

Variant ID Type Subtype PubMed ID
esv3625840 CNV gain 21293372
nsv7728 CNV deletion 18451855
nsv825815 CNV gain 20364138

Additional Variant Information for PAUPAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAUPAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for PAUPAR Gene

Disorders for PAUPAR Gene

MalaCards: The human disease database

(4) MalaCards diseases for PAUPAR Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
melanoma, uveal
  • uveal melanoma
neuroblastoma
  • nb
melanoma
  • malignant melanoma
aniridia 1
  • an1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PAUPAR

genes like me logo Genes that share disorders with PAUPAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAUPAR Gene

Publications for PAUPAR Gene

  1. The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis. (PMID: 29661885) Pavlaki I … Vance KW (The EMBO journal 2018) 2 3
  2. The long non-coding RNA Paupar regulates the expression of both local and distal genes. (PMID: 24488179) Vance KW … Ponting CP (The EMBO journal 2014) 2 3
  3. PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma. (PMID: 27214741) Ding X … Li J (FEBS letters 2016) 3

Products for PAUPAR Gene

Sources for PAUPAR Gene