Aliases for PATE4 Gene

Aliases for PATE4 Gene

  • Prostate And Testis Expressed 4 2 3 5
  • PATE-B 2 3 4
  • Prostate And Testis Expressed Protein 4 3 4
  • PATE-Like Protein B 3 4
  • Prostate And Testis Expression B 3
  • FLJ41047 2
  • PATE4 5

External Ids for PATE4 Gene

Previous GeneCards Identifiers for PATE4 Gene

  • GC11P125210
  • GC11P125703
  • GC11P121645

Summaries for PATE4 Gene

GeneCards Summary for PATE4 Gene

PATE4 (Prostate And Testis Expressed 4) is a Protein Coding gene. An important paralog of this gene is ACRV1.

UniProtKB/Swiss-Prot Summary for PATE4 Gene

  • May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.

Additional gene information for PATE4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PATE4 Gene

Genomics for PATE4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PATE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J125833 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 PATE4 lnc-PATE4-1 PATE3 ENSG00000260209
GH11J125874 Promoter 1 EPDnew Ensembl 10.1 +40.8 40798 0.6 IKZF1 CTCF BRD9 RAD21 MNT DMAP1 ERF ATF1 PATE2 DDX25 PUS3 PATE4 CHEK1 HYLS1 ENSG00000260209 piR-30091-036
GH11J125875 Enhancer 0.7 ENCODE 10.1 +41.4 41385 0.2 CTCF IKZF1 FOXA1 REST RAD21 BRD9 TRIM22 SMC3 MYC SAP130 DDX25 PUS3 PATE4 CHEK1 HYLS1 ENSG00000260209 piR-30091-036
GH11J125873 Enhancer 0.5 Ensembl 10.1 +39.0 38985 0.2 CBX3 TRIM28 ZEB2 FOS BHLHE40 PUS3 DDX25 PATE4 piR-30091-036 HYLS1 ENSG00000260209
GH11J125467 Enhancer 0.5 dbSUPER 5.1 -364.5 -364545 1.6 CEBPA ATF4 HNF4A ATF3 KDM1A HNF4G CEBPG ZNF384 LOC403312 FEZ1 STT3A-AS1 PATE4 lnc-ACRV1-1 EI24 PKNOX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PATE4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PATE4

Top Transcription factor binding sites by QIAGEN in the PATE4 gene promoter:
  • Evi-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for PATE4 Gene

Genomic Locations for PATE4 Gene
chr11:125,833,316-125,840,072
(GRCh38/hg38)
Size:
6,757 bases
Orientation:
Plus strand
chr11:125,703,211-125,709,967
(GRCh37/hg19)
Size:
6,757 bases
Orientation:
Plus strand

Genomic View for PATE4 Gene

Genes around PATE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PATE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PATE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PATE4 Gene

Proteins for PATE4 Gene

  • Protein details for PATE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C8F1-PATE4_HUMAN
    Recommended name:
    Prostate and testis expressed protein 4
    Protein Accession:
    P0C8F1

    Protein attributes for PATE4 Gene

    Size:
    98 amino acids
    Molecular mass:
    11407 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PATE4 Gene

Post-translational modifications for PATE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PATE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PATE4 Gene

Domains & Families for PATE4 Gene

Gene Families for PATE4 Gene

Protein Domains for PATE4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PATE4 Gene

GenScript: Design optimal peptide antigens:
  • PATE-like protein B (PATE4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C8F1

UniProtKB/Swiss-Prot:

PATE4_HUMAN :
  • Belongs to the PATE family.
Family:
  • Belongs to the PATE family.
genes like me logo Genes that share domains with PATE4: view

Function for PATE4 Gene

Molecular function for PATE4 Gene

UniProtKB/Swiss-Prot Function:
May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.

Phenotypes From GWAS Catalog for PATE4 Gene

Gene Ontology (GO) - Molecular Function for PATE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030548 acetylcholine receptor regulator activity IDA 18387948
genes like me logo Genes that share ontologies with PATE4: view
genes like me logo Genes that share phenotypes with PATE4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PATE4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PATE4 Gene

Localization for PATE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PATE4 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PATE4 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PATE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA,IDA 18387948
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 18387948
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PATE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PATE4 Gene

Pathways & Interactions for PATE4 Gene

PathCards logo

SuperPathways for PATE4 Gene

No Data Available

Interacting Proteins for PATE4 Gene

Gene Ontology (GO) - Biological Process for PATE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0099601 regulation of neurotransmitter receptor activity IDA 18387948
genes like me logo Genes that share ontologies with PATE4: view

No data available for Pathways by source and SIGNOR curated interactions for PATE4 Gene

Drugs & Compounds for PATE4 Gene

No Compound Related Data Available

Transcripts for PATE4 Gene

mRNA/cDNA for PATE4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PATE4

Alternative Splicing Database (ASD) splice patterns (SP) for PATE4 Gene

No ASD Table

Relevant External Links for PATE4 Gene

GeneLoc Exon Structure for
PATE4

Expression for PATE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PATE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PATE4 Gene

This gene is overexpressed in Testis (x22.8) and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for PATE4 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PATE4 Gene



Protein tissue co-expression partners for PATE4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PATE4

SOURCE GeneReport for Unigene cluster for PATE4 Gene:

Hs.436215

mRNA Expression by UniProt/SwissProt for PATE4 Gene:

P0C8F1-PATE4_HUMAN
Tissue specificity: Specifically expressed in prostate, testis and spinal cord. Present in the acrosomal region of sperm cells. Present in apical epithelial cells of prostatic duct.
genes like me logo Genes that share expression patterns with PATE4: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PATE4 Gene

Orthologs for PATE4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PATE4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PATE4 30 31
  • 100 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pate4 31
  • 40 (a)
OneToOne
Species where no ortholog for PATE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PATE4 Gene

ENSEMBL:
Gene Tree for PATE4 (if available)
TreeFam:
Gene Tree for PATE4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PATE4: view image

Paralogs for PATE4 Gene

Paralogs for PATE4 Gene

genes like me logo Genes that share paralogs with PATE4: view

Variants for PATE4 Gene

Additional dbSNP identifiers (rs#s) for PATE4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PATE4 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
nsv468888 CNV loss 19166990
nsv556525 CNV gain 21841781
nsv556526 CNV loss 21841781

Variation tolerance for PATE4 Gene

Gene Damage Index Score: 13.92; 95.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PATE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PATE4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PATE4 Gene

Disorders for PATE4 Gene

No disorders were found for PATE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PATE4 Gene

Publications for PATE4 Gene

  1. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li JY … Zhang YL (DNA research : an international journal for rapid publication of reports on genes and genomes 2008) 2 3
  2. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. (PMID: 18387948) Levitin F … Wreschner DH (The Journal of biological chemistry 2008) 3 4
  3. Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction. (PMID: 22402205) Margalit M … Kleiman SE (Human reproduction (Oxford, England) 2012) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for PATE4 Gene

Sources for PATE4 Gene