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This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PASK (PAS Domain Containing Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PASK include Niemann-Pick Disease, Type C1. Among its related pathways are Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 16275910 |
GO:0005515 | protein binding | IPI | 16275910 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 17595531 |
GO:0005737 | cytoplasm | IBA,IDA | 17595531 |
GO:0005829 | cytosol | IBA,IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose / Energy Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IDA | 16275910 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0035556 | intracellular signal transduction | IBA | 21873635 |
GO:0043576 | regulation of respiratory gaseous exchange | ISS | -- |
GO:0045719 | negative regulation of glycogen biosynthetic process | IBA,IDA | 16275910 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||
SP14: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PASK 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pask 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PASK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pask 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PASK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PASK 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PASK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PASK 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PASK 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.32341 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pask 31 |
|
OneToOne | |
wufb69h07 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4074 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pask 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | prk-2 31 |
|
OneToMany | |
prk-1 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PSK2 31 |
|
OneToMany | |
PSK1 31 33 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9130 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8570 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712978 | Likely Benign: not provided | 241,138,025(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
715566 | Likely Benign: not provided | 241,126,339(-) | C/T | MISSENSE_VARIANT | |
717179 | Benign: not provided | 241,106,582(-) | C/T | MISSENSE_VARIANT | |
717180 | Benign: not provided | 241,126,571(-) | C/G | MISSENSE_VARIANT | |
724081 | Likely Benign: not provided | 241,132,996(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv644e201 | CNV | deletion | 23290073 |
esv1931784 | CNV | deletion | 18987734 |
esv2667460 | CNV | deletion | 23128226 |
esv2721976 | CNV | deletion | 23290073 |
esv2721977 | CNV | deletion | 23290073 |
esv2721978 | CNV | deletion | 23290073 |
esv2721981 | CNV | deletion | 23290073 |
esv2721982 | CNV | deletion | 23290073 |
esv2721983 | CNV | deletion | 23290073 |
esv2721985 | CNV | deletion | 23290073 |
esv3575345 | CNV | gain | 25503493 |
nsv214964 | CNV | deletion | 16902084 |
Disorder | Aliases | PubMed IDs |
---|---|---|
niemann-pick disease, type c1 |
|
|