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Aliases for PASK Gene

Aliases for PASK Gene

  • PAS Domain Containing Serine/Threonine Kinase 2 3 5
  • PASKIN 3 4
  • PAS Domain-Containing Serine/Threonine-Protein Kinase 3
  • Per-Arnt-Sim (PAS) Domain Kinase 3
  • EC 2.7.11.1 4
  • PAS-Kinase 4
  • KIAA0135 4
  • STK37 3
  • HPASK 4

External Ids for PASK Gene

Previous GeneCards Identifiers for PASK Gene

  • GC02P239351
  • GC02P240214
  • GC02M242065
  • GC02M242366
  • GC02M241765
  • GC02M233801
  • GC02M242045

Summaries for PASK Gene

Entrez Gene Summary for PASK Gene

  • This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for PASK Gene

PASK (PAS Domain Containing Serine/Threonine Kinase) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM1.

UniProtKB/Swiss-Prot for PASK Gene

  • Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Gene Wiki entry for PASK Gene

Additional gene information for PASK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PASK Gene

Genomics for PASK Gene

GeneHancer (GH) Regulatory Elements for PASK Gene

Promoters and enhancers for PASK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J241148 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 677.1 0.0 -35 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 PASK PPP1R7 ANKMY1 ENSG00000223374 GC02P241182
GH02J241100 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.4 +48.0 47984 3.1 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MTERF4 ENSG00000223374 SNED1 PASK D2HGDH FARP2 ENSG00000235351 LINC01881 ING5 DTYMK
GH02J241108 Enhancer 1.1 Ensembl ENCODE dbSUPER 35.7 +39.7 39694 5.3 HDGF PKNOX1 EBF1 ZBTB40 RELA POLR2A EED IKZF2 RUNX3 ZNF687 PIR57971 GC02M241112 PASK MTERF4 PPP1R7 ANO7 ENSG00000229996 LOC100422094 GC02P241081
GH02J241091 Enhancer 1.1 ENCODE dbSUPER 28.3 +57.3 57303 2.7 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 NFKBIZ RXRA SP5 PASK MTERF4 ANO7 PPP1R7 ENSG00000229996 D2HGDH GC02P241081 SNED1
GH02J241094 Enhancer 1 ENCODE dbSUPER 28 +53.9 53938 3.2 HDGF PKNOX1 BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 IKZF2 PASK MTERF4 ENSG00000223374 PPP1R7 ENSG00000229996 GC02P241081 SNED1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PASK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PASK gene promoter:
  • CUTL1
  • AREB6
  • AML1a
  • c-Myb
  • Egr-2
  • Pax-5
  • NF-1
  • NF-1/L
  • GCNF-2

Genomic Locations for PASK Gene

Genomic Locations for PASK Gene
chr2:241,106,099-241,150,364
(GRCh38/hg38)
Size:
44,266 bases
Orientation:
Minus strand
chr2:242,045,514-242,089,679
(GRCh37/hg19)
Size:
44,166 bases
Orientation:
Minus strand

Genomic View for PASK Gene

Genes around PASK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PASK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PASK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PASK Gene

Proteins for PASK Gene

  • Protein details for PASK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RG2-PASK_HUMAN
    Recommended name:
    PAS domain-containing serine/threonine-protein kinase
    Protein Accession:
    Q96RG2
    Secondary Accessions:
    • G5E9F1
    • Q05BE4
    • Q68DY3
    • Q6GSJ5
    • Q86XH6
    • Q99763
    • Q9UFR7

    Protein attributes for PASK Gene

    Size:
    1323 amino acids
    Molecular mass:
    142929 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09484.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PASK Gene

    Alternative splice isoforms for PASK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PASK Gene

Post-translational modifications for PASK Gene

  • Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PASK Gene

Domains & Families for PASK Gene

Gene Families for PASK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96RG2

UniProtKB/Swiss-Prot:

PASK_HUMAN :
  • The protein kinase domain mediates binding to phosphatidylinositol.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain mediates binding to phosphatidylinositol.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PASK: view

Function for PASK Gene

Molecular function for PASK Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).

Enzyme Numbers (IUBMB) for PASK Gene

Phenotypes From GWAS Catalog for PASK Gene

Gene Ontology (GO) - Molecular Function for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 16275910
GO:0005515 protein binding IPI 16275910
GO:0005524 ATP binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PASK: view
genes like me logo Genes that share phenotypes with PASK: view

Animal Models for PASK Gene

MGI Knock Outs for PASK:
  • Pask Pask<tm1Weng>

Animal Model Products

  • Taconic Biosciences Mouse Models for PASK

miRNA for PASK Gene

miRTarBase miRNAs that target PASK

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PASK Gene

Localization for PASK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PASK Gene

Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PASK gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17595531
GO:0005737 cytoplasm IDA,IEA 17595531
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PASK: view

Pathways & Interactions for PASK Gene

SuperPathway Contained pathways
1 Glucose / Energy Metabolism
genes like me logo Genes that share pathways with PASK: view

Pathways by source for PASK Gene

1 Cell Signaling Technology pathway for PASK Gene

SIGNOR curated interactions for PASK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PASK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 16275910
GO:0010906 regulation of glucose metabolic process IBA --
GO:0016310 phosphorylation IEA --
GO:0043576 regulation of respiratory gaseous exchange ISS --
GO:0045719 negative regulation of glycogen biosynthetic process IDA 16275910
genes like me logo Genes that share ontologies with PASK: view

Drugs & Compounds for PASK Gene

(4) Drugs for PASK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for PASK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PASK: view

Transcripts for PASK Gene

mRNA/cDNA for PASK Gene

(16) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PASK Gene

PAS domain containing serine/threonine kinase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PASK Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
SP1: - - - - - -
SP2:
SP3: - - - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12: -
SP13:
SP14:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PASK Gene

GeneLoc Exon Structure for
PASK
ECgene alternative splicing isoforms for
PASK

Expression for PASK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PASK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PASK Gene

This gene is overexpressed in Testis (43.3), Retina (10.2), and Ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PASK Gene



Protein tissue co-expression partners for PASK Gene

NURSA nuclear receptor signaling pathways regulating expression of PASK Gene:

PASK

SOURCE GeneReport for Unigene cluster for PASK Gene:

Hs.397891

mRNA Expression by UniProt/SwissProt for PASK Gene:

Q96RG2-PASK_HUMAN
Tissue specificity: Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).

Evidence on tissue expression from TISSUES for PASK Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with PASK: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PASK Gene

Orthologs for PASK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PASK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PASK 34 33
  • 98.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pask 16 34 33
  • 76.92 (n)
dog
(Canis familiaris)
Mammalia PASK 34 33
  • 76.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pask 33
  • 75.59 (n)
cow
(Bos Taurus)
Mammalia PASK 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PASK 34
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PASK 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PASK 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PASK 34
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32341 33
zebrafish
(Danio rerio)
Actinopterygii pask 34
  • 33 (a)
OneToOne
wufb69h07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4074 33
fruit fly
(Drosophila melanogaster)
Insecta Pask 34
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prk-2 34
  • 23 (a)
OneToMany
prk-1 34
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSK2 34
  • 19 (a)
OneToMany
PSK1 36 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9130 34
  • 39 (a)
OneToOne
Cin.8570 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8570 33
Species where no ortholog for PASK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PASK Gene

ENSEMBL:
Gene Tree for PASK (if available)
TreeFam:
Gene Tree for PASK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PASK: view image

Paralogs for PASK Gene

Paralogs for PASK Gene

(35) SIMAP similar genes for PASK Gene using alignment to 7 proteins:

  • PASK_HUMAN
  • B7Z7V7_HUMAN
  • C9J1Z3_HUMAN
  • C9J4R3_HUMAN
  • F5GYW7_HUMAN
  • F8WEB4_HUMAN
  • H7C0L7_HUMAN
genes like me logo Genes that share paralogs with PASK: view

Variants for PASK Gene

Sequence variations from dbSNP and Humsavar for PASK Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_040986 A metastatic melanoma sample p.Glu11Lys
rs140030739 uncertain-significance, not specified 241,112,239(-) C/T genic_downstream_transcript_variant, splice_donor_variant
rs1000010692 -- 241,149,177(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000041848 -- 241,148,985(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000063982 -- 241,114,594(-) T/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PASK Gene

Variant ID Type Subtype PubMed ID
dgv644e201 CNV deletion 23290073
esv1931784 CNV deletion 18987734
esv2667460 CNV deletion 23128226
esv2721976 CNV deletion 23290073
esv2721977 CNV deletion 23290073
esv2721978 CNV deletion 23290073
esv2721981 CNV deletion 23290073
esv2721982 CNV deletion 23290073
esv2721983 CNV deletion 23290073
esv2721985 CNV deletion 23290073
esv3575345 CNV gain 25503493
nsv214964 CNV deletion 16902084

Variation tolerance for PASK Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.96; 91.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PASK Gene

Human Gene Mutation Database (HGMD)
PASK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PASK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PASK Gene

Disorders for PASK Gene

Additional Disease Information for PASK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PASK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PASK Gene

Publications for PASK Gene

  1. Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. (PMID: 17595531) Eckhardt K … Wenger RH (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007) 3 4 22 58
  2. Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. (PMID: 15148392) da Silva Xavier G … Rutter GA (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 22 58
  3. Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. (PMID: 12377121) Amezcua CA … Gardner KH (Structure (London, England : 1993) 2002) 3 4 22 58
  4. Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. (PMID: 11688972) Hofer T … Wenger RH (Biochemical and biophysical research communications 2001) 2 3 22 58
  5. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. (PMID: 11459942) Rutter J … McKnight SL (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58

Products for PASK Gene

Sources for PASK Gene

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