Aliases for PASK Gene
Aliases for PASK Gene
External Ids for PASK Gene
- HGNC: 17270
- Entrez Gene: 23178
- Ensembl: ENSG00000115687
- OMIM: 607505
- UniProtKB: Q96RG2
Previous GeneCards Identifiers for PASK Gene
- GC02P239351
- GC02P240214
- GC02M242065
- GC02M242366
- GC02M241765
- GC02M233801
- GC02M242045
Summaries for PASK Gene
-
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for PASK Gene
PASK (PAS Domain Containing Serine/Threonine Kinase) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM1.
UniProtKB/Swiss-Prot for PASK Gene
-
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
Additional gene information for PASK Gene
- Monarch Initiative
- Search for PASK at DataMed
- Search for PASK at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PASK Gene
Genomics for PASK Gene
GeneHancer (GH) Regulatory Elements for PASK Gene
Promoters and enhancers for PASK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PASK on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PASK Gene
Genomic Locations for PASK Gene
- chr2:241,106,099-241,150,364
- (GRCh38/hg38)
- Size:
- 44,266 bases
- Orientation:
- Minus strand
- chr2:242,045,514-242,089,679
- (GRCh37/hg19)
Genomic View for PASK Gene
Genes around PASK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by Entrez Gene
- 2q37.3 by HGNC
- 2q37.3 by Ensembl
PASK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PASK Gene
Proteins for PASK Gene
-
Protein details for PASK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RG2-PASK_HUMAN
- Recommended name:
- PAS domain-containing serine/threonine-protein kinase
- Protein Accession:
- Q96RG2
- G5E9F1
- Q05BE4
- Q68DY3
- Q6GSJ5
- Q86XH6
- Q99763
- Q9UFR7
Protein attributes for PASK Gene
- Size:
- 1323 amino acids
- Molecular mass:
- 142929 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA09484.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for PASK Gene
Post-translational modifications for PASK Gene
- Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PASK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PASK
- Invitrogen Antibodies for PASK
- GeneTex PASK Antibody for PASK
Protein Products
-
OriGene Purified Proteins for PASK
- Search Origene for MassSpec and Protein Over-expression Lysates for PASK
- Origene Custom Protein Services for PASK
- Search GeneTex for Proteins for PASK
Assay Products
No data available for DME Specific Peptides for PASK Gene
Domains & Families for PASK Gene
Gene Families for PASK Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PASK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PASK Gene
Graphical View of Domain Structure for InterPro Entry
Q96RG2UniProtKB/Swiss-Prot:
PASK_HUMAN :- The protein kinase domain mediates binding to phosphatidylinositol.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
- Domain:
-
- The protein kinase domain mediates binding to phosphatidylinositol.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Function for PASK Gene
Molecular function for PASK Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).
Enzyme Numbers (IUBMB) for PASK Gene
Phenotypes From GWAS Catalog for PASK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,IDA | 16275910 |
| GO:0005515 | protein binding | IPI | 16275910 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for PASK Gene
- MGI mutant phenotypes for PASK:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PASK:
-
- Decreased viability ratio
- Decreased substrate adherent cell growth
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased cell death HMECs cells
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Lamellipodia cells
Animal Models for PASK Gene
- MGI Knock Outs for PASK:
-
- Pask Pask<tm1Weng>
Animal Model Products
-
Taconic Biosciences Mouse Models for PASK
- Cyagen custom Knockout/knockin (KOKI) mouse models for PASK
-
CRISPR Products
-
OriGene CRISPR knockouts for PASK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PASK
- genomics-online: gRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- Applied Biological Materials CRISPR for PASK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PASK
- GenScript: Design CRISPR guide RNA sequences for PASK
miRNA for PASK Gene
- miRTarBase miRNAs that target PASK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PASK
- Browse OriGene Inhibitory RNA Products For PASK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PASK
- genomics-online: shRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PASK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PASK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PASK
- Applied Biological Materials Clones for PASK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PASK Gene
Localization for PASK Gene
Subcellular locations from UniProtKB/Swiss-Prot for PASK Gene
- Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 17595531 |
| GO:0005737 | cytoplasm | IDA,IEA | 17595531 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for PASK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose / Energy Metabolism | ||
Pathways by source for PASK Gene
1 Cell Signaling Technology pathway for PASK Gene
Interacting Proteins for PASK Gene
Selected Interacting proteins:
Q96RG2-PASK_HUMAN
ENSP00000234040
for PASK Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for PASK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 16275910 |
| GO:0010906 | regulation of glucose metabolic process | IBA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0043576 | regulation of respiratory gaseous exchange | ISS | -- |
| GO:0045719 | negative regulation of glycogen biosynthetic process | IDA | 16275910 |
Drugs & Compounds for PASK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Transcripts for PASK Gene
mRNA/cDNA for PASK Gene
- (2) Selected AceView cDNA sequences:
- (13) Additional mRNA sequences :
- (16) REFSEQ mRNAs :
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000234040 4572 bps (uc002wao.2)
- ENST00000358649 4326 bps (uc010fzl.3)
- ENST00000403638 5161 bps (uc002waq.4)
- ENST00000405260 4942 bps (uc061ull.1)
- ENST00000415234 538 bps (uc061ulr.1)
Unigene Clusters for PASK Gene
- PAS domain containing serine/threonine kinase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PASK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PASK
- genomics-online: gRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- Applied Biological Materials CRISPR for PASK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PASK
- GenScript: Design CRISPR guide RNA sequences for PASK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PASK
- Browse OriGene Inhibitory RNA Products For PASK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PASK
- genomics-online: shRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PASK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PASK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PASK
- Applied Biological Materials Clones for PASK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: |
Expression for PASK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T-Cytotoxic Cells Peripheral Blood
This gene is overexpressed in Testis (43.3), Retina (10.2), and Ovary (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PASK Gene
NURSA nuclear receptor signaling pathways regulating expression of PASK Gene:
PASKSOURCE GeneReport for Unigene cluster for PASK Gene:
Hs.397891mRNA Expression by UniProt/SwissProt for PASK Gene:
Q96RG2-PASK_HUMAN
Tissue specificity:
Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
Evidence on tissue expression from TISSUES for PASK Gene
- Nervous system(4.3)
- Bone marrow(4.2)
- Eye(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PASK
-
OriGene qPCR primer pairs for PASK
- genomics-online: primer clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PASK Gene
Orthologs for PASK Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PASK 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pask 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PASK 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pask 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PASK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PASK 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PASK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PASK 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PASK 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.32341 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pask 34 |
|
OneToOne | |
| wufb69h07 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4074 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pask 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | prk-2 34 |
|
OneToMany | |
| prk-1 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PSK2 34 |
|
OneToMany | |
| PSK1 36 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9130 34 |
|
OneToOne | |
| Cin.8570 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8570 33 |
|
- Species where no ortholog for PASK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for PASK Gene
- ENSEMBL:
- Gene Tree for PASK (if available)
- TreeFam:
- Gene Tree for PASK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PASK: view image
Paralogs for PASK Gene
(35) SIMAP similar genes for PASK Gene using alignment to 7 proteins:
- PASK_HUMAN
- B7Z7V7_HUMAN
- C9J1Z3_HUMAN
- C9J4R3_HUMAN
- F5GYW7_HUMAN
- F8WEB4_HUMAN
- H7C0L7_HUMAN
Variants for PASK Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040986 | A metastatic melanoma sample | p.Glu11Lys | |||
| rs140030739 | uncertain-significance, not specified | 241,112,239(-) | C/T | genic_downstream_transcript_variant, splice_donor_variant | |
| rs1000010692 | -- | 241,149,177(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000041848 | -- | 241,148,985(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000063982 | -- | 241,114,594(-) | T/C | 3_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv644e201 | CNV | deletion | 23290073 |
| esv1931784 | CNV | deletion | 18987734 |
| esv2667460 | CNV | deletion | 23128226 |
| esv2721976 | CNV | deletion | 23290073 |
| esv2721977 | CNV | deletion | 23290073 |
| esv2721978 | CNV | deletion | 23290073 |
| esv2721981 | CNV | deletion | 23290073 |
| esv2721982 | CNV | deletion | 23290073 |
| esv2721983 | CNV | deletion | 23290073 |
| esv2721985 | CNV | deletion | 23290073 |
| esv3575345 | CNV | gain | 25503493 |
| nsv214964 | CNV | deletion | 16902084 |
Residual Variation Intolerance Score:
31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.96;
91.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PASK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PASK Gene
Disorders for PASK Gene
Additional Disease Information for PASK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PASK Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PASK Gene
Publications for PASK Gene
- Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. (PMID: 17595531) Eckhardt K … Wenger RH (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007) 3 4 22 58
- Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. (PMID: 15148392) da Silva Xavier G … Rutter GA (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 22 58
- Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. (PMID: 12377121) Amezcua CA … Gardner KH (Structure (London, England : 1993) 2002) 3 4 22 58
- Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. (PMID: 11688972) Hofer T … Wenger RH (Biochemical and biophysical research communications 2001) 2 3 22 58
- PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. (PMID: 11459942) Rutter J … McKnight SL (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
Products for PASK Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PASK
- Search Origene for MassSpec and Protein Over-expression Lysates for PASK
- Origene Custom Protein Services for PASK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PASK
- Browse OriGene Inhibitory RNA Products For PASK
- OriGene qPCR primer pairs and template standards for PASK
- OriGene qPCR primer pairs for PASK
- OriGene CRISPR knockouts for PASK
- OriGene ORF clones in human for PASK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PASK
- GenScript: Next-day shipping of latest version cDNA ORF clones for PASK in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PASK
- GenScript Custom Assay Services for PASK
- GenScript Custom overexpressing Cell Line Services for PASK
- GenScript: Design CRISPR guide RNA sequences for PASK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PASK
- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PASK
- Novus Biologicals proteins and lysates for PASK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Browse Lysates
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- Taconic Biosciences Mouse Models for PASK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for PASK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PASK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 27 available PASK Antibodies ranked by validation data
- Compare Top PASK Antibodies
- antibodies-online: Search results for 2 available PASK Elisa Kits ranked by validation data
- Compare Top PASK Elisa Kits
- Recommended
- antibodies-online: Search results for 7 available PASK Proteins ranked by validation data
- Compare Top PASK Proteins
- GeneTex PASK Antibody for PASK
- Search GeneTex for Proteins for PASK
- Horizon Cell Lines for PASK
- genomics-online: cdna clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- orf clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- genomics-online: gRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- genomics-online: primer clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- genomics-online: shRNA clones - Search results for 102 available PASK gene related products
- Overview of 102 available PASK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PASK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PASK
- GeneCopoeia miRNA 3'UTR Target clone products for PASK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PASK
Sources for PASK Gene
- (1) GeneCards
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- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (14) ProtoNet
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- (20) STRING
- (21) IntAct
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio