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Aliases for PARVG Gene

Aliases for PARVG Gene

  • Parvin Gamma 2 3 5
  • Gamma-Parvin 3

External Ids for PARVG Gene

Previous GeneCards Identifiers for PARVG Gene

  • GC22P041194
  • GC22P042827
  • GC22P042835
  • GC22P042901
  • GC22P044568
  • GC22P027520

Summaries for PARVG Gene

Entrez Gene Summary for PARVG Gene

  • Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]

GeneCards Summary for PARVG Gene

PARVG (Parvin Gamma) is a Protein Coding gene. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PARVB.

UniProtKB/Swiss-Prot for PARVG Gene

  • Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.

Gene Wiki entry for PARVG Gene

Additional gene information for PARVG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVG Gene

Genomics for PARVG Gene

GeneHancer (GH) Regulatory Elements for PARVG Gene

Promoters and enhancers for PARVG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J044179 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 658 +11.5 11511 3.7 HDGF PKNOX1 SMAD1 RFX5 SCRT2 ZNF207 ZNF143 RUNX3 CREM EGR2 PARVG SAMM50 ENSG00000279933
GH22J044171 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 657.5 +2.8 2846 3.1 HDGF PKNOX1 SMAD1 IRF4 EGR1 ATF7 IKZF2 RUNX3 CREM EGR2 PARVG SAMM50 ENSG00000279933 PARVB
GH22J044619 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +450.3 450257 1.7 HDGF SIN3A YBX1 BMI1 RAD21 RFX5 ZFP91 RXRA NR2F2 SP1 PARVG PRR5 LOC105373060 LINC00229 LINC00207
GH22J044154 Enhancer 0.9 ENCODE dbSUPER 10.7 -15.6 -15630 0.2 ZNF493 ZSCAN4 INSM2 ZNF266 ZNF175 BMI1 ZNF514 ZFHX2 POLR2A ZNF157 PHF21B ENSG00000261251 PARVG RPL35AP36 SAMM50 TRU-TCA2-1 PARVB
GH22J044145 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.7 -22.7 -22689 4.7 SUZ12 MAX BACH1 SIN3A STAT5A ZNF664 ZFHX2 POLR2A NFATC1 EGR2 ENSG00000220702 PARVG TRU-TCA2-1 ENSG00000280434 PARVB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARVG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARVG gene promoter:
  • p53
  • Pbx1a
  • CREB
  • deltaCREB

Genomic Locations for PARVG Gene

Genomic Locations for PARVG Gene
49,307 bases
Plus strand
46,578 bases
Plus strand

Genomic View for PARVG Gene

Genes around PARVG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARVG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARVG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVG Gene

Proteins for PARVG Gene

  • Protein details for PARVG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DDW5
    • E7EVM6
    • Q9BQX5
    • Q9NSG1

    Protein attributes for PARVG Gene

    331 amino acids
    Molecular mass:
    37485 Da
    Quaternary structure:
    • Interacts with integrin-linked protein kinase and actin.

    Alternative splice isoforms for PARVG Gene


neXtProt entry for PARVG Gene

Post-translational modifications for PARVG Gene

  • Ubiquitination at Lys213
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARVG Gene

Domains & Families for PARVG Gene

Gene Families for PARVG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PARVG Gene

Suggested Antigen Peptide Sequences for PARVG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the parvin family.
  • Belongs to the parvin family.
genes like me logo Genes that share domains with PARVG: view

Function for PARVG Gene

Molecular function for PARVG Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.

Phenotypes From GWAS Catalog for PARVG Gene

Gene Ontology (GO) - Molecular Function for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 11171322
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PARVG: view
genes like me logo Genes that share phenotypes with PARVG: view

Animal Models for PARVG Gene

MGI Knock Outs for PARVG:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARVG Gene

Localization for PARVG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVG Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Constituent of focal adhesions. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARVG gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton TAS 11171322
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA --
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with PARVG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PARVG Gene

Pathways & Interactions for PARVG Gene

SuperPathways for PARVG Gene

SuperPathway Contained pathways
1 Focal Adhesion
genes like me logo Genes that share pathways with PARVG: view

Pathways by source for PARVG Gene

1 KEGG pathway for PARVG Gene

Gene Ontology (GO) - Biological Process for PARVG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 11171322
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0030031 cell projection assembly IBA --
GO:0031532 actin cytoskeleton reorganization IEA --
genes like me logo Genes that share ontologies with PARVG: view

No data available for SIGNOR curated interactions for PARVG Gene

Drugs & Compounds for PARVG Gene

No Compound Related Data Available

Transcripts for PARVG Gene

Unigene Clusters for PARVG Gene

Parvin, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARVG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b

Relevant External Links for PARVG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARVG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARVG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARVG Gene

This gene is overexpressed in Whole Blood (x16.8) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for PARVG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Monocytes (10.0), Spleen (8.0), NK cells (7.3), and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARVG Gene

Protein tissue co-expression partners for PARVG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARVG Gene:


SOURCE GeneReport for Unigene cluster for PARVG Gene:


mRNA Expression by UniProt/SwissProt for PARVG Gene:

Tissue specificity: Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.

Evidence on tissue expression from TISSUES for PARVG Gene

  • Nervous system(4.5)
  • Spleen(4.4)
  • Lung(4.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PARVG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PARVG Gene

Orthologs for PARVG Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARVG 34 33
  • 98.79 (n)
(Bos Taurus)
Mammalia PARVG 33
  • 84.79 (n)
MGC148449 34
  • 81 (a)
(Canis familiaris)
Mammalia PARVG 34 33
  • 84.39 (n)
(Mus musculus)
Mammalia Parvg 16 34 33
  • 81.87 (n)
(Rattus norvegicus)
Mammalia Parvg 33
  • 81.31 (n)
(Monodelphis domestica)
Mammalia PARVG 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PARVG 34
  • 59 (a)
(Gallus gallus)
Aves PARVG 34 33
  • 60.92 (n)
(Anolis carolinensis)
Reptilia PARVG 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parvg 33
  • 64.61 (n)
(Danio rerio)
Actinopterygii parvg 34 33
  • 61.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32528 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea pat-6 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for PARVG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVG Gene

Gene Tree for PARVG (if available)
Gene Tree for PARVG (if available)
Evolutionary constrained regions (ECRs) for PARVG: view image

Paralogs for PARVG Gene

Paralogs for PARVG Gene

(2) SIMAP similar genes for PARVG Gene using alignment to 4 proteins:

  • U3KQ67_HUMAN
genes like me logo Genes that share paralogs with PARVG: view

Variants for PARVG Gene

Sequence variations from dbSNP and Humsavar for PARVG Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000000265 -- 44,205,008(+) A/G intron_variant
rs1000066302 -- 44,171,451(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000102608 -- 44,187,951(+) G/A intron_variant
rs1000145977 -- 44,169,660(+) C/A/T upstream_transcript_variant
rs1000191469 -- 44,190,727(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PARVG Gene

Variant ID Type Subtype PubMed ID
nsv1059584 CNV gain 25217958
nsv508740 CNV insertion 20534489
nsv510518 OTHER sequence alteration 20534489
nsv9915 CNV loss 18304495

Variation tolerance for PARVG Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARVG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARVG Gene

Disorders for PARVG Gene

Additional Disease Information for PARVG

No disorders were found for PARVG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARVG Gene

Publications for PARVG Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski TM … Korenbaum E (Journal of cell science 2001) 2 3 4 22 58
  2. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. (PMID: 11722847) Korenbaum E … Noegel AA (Gene 2001) 3 4 22 58
  3. The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction. (PMID: 16517730) Yoshimi R … Ishigatsubo Y (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 22 58
  4. No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in oligodendroglial neoplasms. (PMID: 15993274) Alonso ME … Rey JA (Cancer genetics and cytogenetics 2005) 3 22 58
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58

Products for PARVG Gene

Sources for PARVG Gene

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