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Aliases for PARVB Gene

Aliases for PARVB Gene

  • Parvin Beta 2 3 5
  • Affixin 2 3 4
  • Beta-Parvin 3
  • CGI-56 3

External Ids for PARVB Gene

Previous GeneCards Identifiers for PARVB Gene

  • GC22P041036
  • GC22P042653
  • GC22P042678
  • GC22P042545
  • GC22P042719
  • GC22P044395
  • GC22P027349

Summaries for PARVB Gene

Entrez Gene Summary for PARVB Gene

  • This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PARVB Gene

PARVB (Parvin Beta) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PARVA.

UniProtKB/Swiss-Prot for PARVB Gene

  • Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Gene Wiki entry for PARVB Gene

Additional gene information for PARVB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARVB Gene

Genomics for PARVB Gene

GeneHancer (GH) Regulatory Elements for PARVB Gene

Promoters and enhancers for PARVB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I044023 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 565.9 +26.7 26747 4.7 HDGF PKNOX1 ATF1 SMAD1 SIN3A DMAP1 IRF4 POLR2B ZNF207 ZNF143 PARVB GC22M044040
GH22I044067 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 551.9 +69.2 69245 2.3 HDGF CTCF MAX EBF1 BMI1 BATF RELA ZNF143 ETV6 IKZF2 PARVB GC22M044040 ENSG00000279175
GH22I043999 Promoter 0.5 EPDnew 550.8 0.0 -9 0.1 PIR60090 PARVB SAMM50
GH22I044075 Promoter 0.5 EPDnew 550.2 +75.9 75922 0.1 PARVB ENSG00000279175 GC22M044040
GH22I044020 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +22.5 22500 2.2 ZNF473 ZSCAN4 INSM2 GLI4 ZEB1 ZNF335 ZNF366 ZNF391 FOS YY2 ENSG00000261251 LOC100506679 SAMM50 RPL35AP36 RTL6 SHISAL1 PHF21B TTLL1 PARVB GC22M044040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PARVB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARVB gene promoter:

Genomic Locations for PARVB Gene

Genomic Locations for PARVB Gene
173,739 bases
Plus strand

Genomic View for PARVB Gene

Genes around PARVB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARVB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARVB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARVB Gene

Proteins for PARVB Gene

  • Protein details for PARVB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B0QYM8
    • B0QYN1
    • B2R9X6
    • Q5TGJ5
    • Q86X93
    • Q96PN1
    • Q9NSP7
    • Q9UGT3
    • Q9Y368
    • Q9Y3L6
    • Q9Y3L7

    Protein attributes for PARVB Gene

    364 amino acids
    Molecular mass:
    41714 Da
    Quaternary structure:
    • Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
    • Sequence=AAD34051.1; Type=Frameshift; Positions=4, 14, 48, 58, 155, 162, 171, 327, 331, 344; Evidence={ECO:0000305}; Sequence=BG743702; Type=Frameshift; Positions=136, 232, 237; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARVB Gene

    Alternative splice isoforms for PARVB Gene


neXtProt entry for PARVB Gene

Post-translational modifications for PARVB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PARVB Gene

Domains & Families for PARVB Gene

Gene Families for PARVB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PARVB Gene

Suggested Antigen Peptide Sequences for PARVB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the parvin family.
  • Belongs to the parvin family.
genes like me logo Genes that share domains with PARVB: view

Function for PARVB Gene

Molecular function for PARVB Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Phenotypes From GWAS Catalog for PARVB Gene

Gene Ontology (GO) - Molecular Function for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18325335
genes like me logo Genes that share ontologies with PARVB: view
genes like me logo Genes that share phenotypes with PARVB: view

Animal Models for PARVB Gene

MGI Knock Outs for PARVB:

Animal Model Products

CRISPR Products

miRNA for PARVB Gene

miRTarBase miRNAs that target PARVB

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARVB Gene

Localization for PARVB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARVB Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARVB gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA,IEA 22869380
genes like me logo Genes that share ontologies with PARVB: view

Pathways & Interactions for PARVB Gene

genes like me logo Genes that share pathways with PARVB: view

Pathways by source for PARVB Gene

1 GeneGo (Thomson Reuters) pathway for PARVB Gene
1 Qiagen pathway for PARVB Gene

Gene Ontology (GO) - Biological Process for PARVB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0030031 cell projection assembly IMP 15005707
GO:0030032 lamellipodium assembly IMP 18325335
GO:0031532 actin cytoskeleton reorganization IEA,IMP 15005707
GO:0071963 establishment or maintenance of cell polarity regulating cell shape IMP 15005707
genes like me logo Genes that share ontologies with PARVB: view

No data available for SIGNOR curated interactions for PARVB Gene

Drugs & Compounds for PARVB Gene

No Compound Related Data Available

Transcripts for PARVB Gene

Unigene Clusters for PARVB Gene

Parvin, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARVB Gene

No ASD Table

Relevant External Links for PARVB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARVB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARVB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARVB Gene

This gene is overexpressed in Muscle - Skeletal (x5.7).

Protein differential expression in normal tissues from HIPED for PARVB Gene

This gene is overexpressed in Platelet (45.6) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PARVB Gene

NURSA nuclear receptor signaling pathways regulating expression of PARVB Gene:


SOURCE GeneReport for Unigene cluster for PARVB Gene:


mRNA Expression by UniProt/SwissProt for PARVB Gene:

Tissue specificity: Expressed predominantly in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PARVB Gene

  • Muscle(4.4)
  • Blood(4.2)
  • Intestine(4.2)
  • Nervous system(4.2)
  • Skin(4.1)
  • Pancreas(2.5)
  • Heart(2)
genes like me logo Genes that share expression patterns with PARVB: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARVB Gene

Orthologs for PARVB Gene

This gene was present in the common ancestor of animals.

Orthologs for PARVB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARVB 33 34
  • 99.18 (n)
(Canis familiaris)
Mammalia PARVB 33
  • 88.69 (n)
(Bos Taurus)
Mammalia PARVB 33 34
  • 87.09 (n)
(Rattus norvegicus)
Mammalia Parvb 33
  • 86.38 (n)
(Mus musculus)
Mammalia Parvb 33 16 34
  • 85.81 (n)
(Ornithorhynchus anatinus)
Mammalia PARVB 34
  • 63 (a)
(Gallus gallus)
Aves PARVB 33 34
  • 79.52 (n)
(Anolis carolinensis)
Reptilia PARVB 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parvb 33
  • 78.1 (n)
Str.5959 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29274 33
(Danio rerio)
Actinopterygii parvb 33 34
  • 71.63 (n)
wufd02e01 33
fruit fly
(Drosophila melanogaster)
Insecta parvin 33
  • 65.03 (n)
CG32528 34
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002356 33
  • 64.05 (n)
(Caenorhabditis elegans)
Secernentea pat-6 35 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3317 33
Species where no ortholog for PARVB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PARVB Gene

Gene Tree for PARVB (if available)
Gene Tree for PARVB (if available)

Paralogs for PARVB Gene

Paralogs for PARVB Gene

(3) SIMAP similar genes for PARVB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PARVB: view

Variants for PARVB Gene

Sequence variations from dbSNP and Humsavar for PARVB Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000027483 -- 44,097,959(+) C/T intron_variant
rs1000039364 -- 44,027,173(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000109619 -- 44,101,438(+) T/A intron_variant
rs1000115794 -- 44,149,435(+) C/A/G intron_variant
rs1000127948 -- 44,124,829(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PARVB Gene

Variant ID Type Subtype PubMed ID
esv1420958 CNV insertion 17803354
esv1973166 CNV deletion 18987734
esv2005538 CNV deletion 18987734
esv22732 CNV gain 19812545
esv2356466 CNV deletion 18987734
esv2660969 CNV deletion 23128226
esv2670736 CNV deletion 23128226
esv2672411 CNV deletion 23128226
esv2676055 CNV deletion 23128226
esv2724331 CNV deletion 23290073
esv2724332 CNV deletion 23290073
esv2724333 CNV deletion 23290073
esv2724334 CNV deletion 23290073
esv2724335 CNV deletion 23290073
esv2724336 CNV deletion 23290073
esv2724337 CNV deletion 23290073
esv2724338 CNV deletion 23290073
esv2724340 CNV deletion 23290073
esv2724341 CNV deletion 23290073
esv2724342 CNV deletion 23290073
esv2724343 CNV deletion 23290073
esv2724344 CNV deletion 23290073
esv2724345 CNV deletion 23290073
esv27983 CNV loss 19812545
esv3558211 CNV deletion 23714750
esv3568433 CNV loss 25503493
esv3647885 CNV loss 21293372
esv3647886 CNV loss 21293372
esv3647887 CNV loss 21293372
esv3647888 CNV loss 21293372
esv3647889 CNV loss 21293372
esv3893489 CNV loss 25118596
esv991955 CNV insertion 20482838
nsv1118695 CNV duplication 24896259
nsv1131664 CNV deletion 24896259
nsv1139070 CNV deletion 24896259
nsv1144976 CNV deletion 24896259
nsv459895 CNV gain 19166990
nsv471206 CNV gain 18288195
nsv475667 CNV novel sequence insertion 20440878
nsv476245 CNV novel sequence insertion 20440878
nsv508740 CNV insertion 20534489
nsv510809 CNV deletion 20534489
nsv589101 CNV gain 21841781
nsv820857 CNV deletion 20802225
nsv834219 CNV gain 17160897
nsv955494 CNV deletion 24416366

Variation tolerance for PARVB Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARVB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARVB Gene

Disorders for PARVB Gene

Additional Disease Information for PARVB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PARVB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARVB Gene

Publications for PARVB Gene

  1. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. (PMID: 11171322) Olski TM … Korenbaum E (Journal of cell science 2001) 2 3 4 22 58
  2. Affixin activates Rac1 via betaPIX in C2C12 myoblast. (PMID: 18325335) Matsuda C … Hayashi YK (FEBS letters 2008) 3 4 22 58
  3. Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. (PMID: 15835269) Matsuda C … Hayashi YK (Journal of neuropathology and experimental neurology 2005) 3 4 22 58
  4. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. (PMID: 15005707) Mishima W … Ishigatsubo Y (Genes to cells : devoted to molecular & cellular mechanisms 2004) 3 4 22 58
  5. Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. (PMID: 15159419) Yamaji S … Ishigatsubo Y (The Journal of cell biology 2004) 3 4 22 58

Products for PARVB Gene

Sources for PARVB Gene

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