Aliases for PARVA Gene
External Ids for PARVA Gene
Previous HGNC Symbols for PARVA Gene
Previous GeneCards Identifiers for PARVA Gene
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
GeneCards Summary for PARVA Gene
PARVA (Parvin Alpha) is a Protein Coding gene. Diseases associated with PARVA include Metagonimiasis and Breast Giant Fibroadenoma. Among its related pathways are Focal Adhesion and ERK Signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PARVB.
UniProtKB/Swiss-Prot Summary for PARVA Gene
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.