Aliases for PARP9 Gene

Aliases for PARP9 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 9 2 3 5
  • ARTD9 2 3 4
  • BAL1 2 3 4
  • BAL 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 9 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP9 3 4
  • Poly [ADP-Ribose] Polymerase 9 3 4
  • B Aggressive Lymphoma Protein 3 4
  • PARP-9 3 4
  • Poly (ADP-Ribose) Polymerase 9 3
  • EC 2.4.2.- 4
  • MGC:7868 3
  • PARP9 5

External Ids for PARP9 Gene

Previous GeneCards Identifiers for PARP9 Gene

  • GC03M123729
  • GC03M122246
  • GC03M119620

Summaries for PARP9 Gene

GeneCards Summary for PARP9 Gene

PARP9 (Poly(ADP-Ribose) Polymerase Family Member 9) is a Protein Coding gene. Diseases associated with PARP9 include B-Cell Lymphoma and Lymphoma. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot Summary for PARP9 Gene

  • ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).

Tocris Summary for PARP9 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP9 Gene

Genomics for PARP9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J122562 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.4 398 3.2 ZNF600 ZNF592 POLR2A ZIC2 YY1 MXD4 KLF11 SIN3A ZNF341 KLF7 DTX3L PARP9 WDR5B-DT PARP14 WDR5B KPNA1
GH03J122678 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 -116.5 -116514 5.9 BCLAF1 ZNF207 ZNF654 ZNF600 ZNF580 ZMYM3 POLR2A NFIC ZBTB10 YY1 PARP14 DTX3L PARP9 HSPBAP1 SLC49A4 LINC02035 CSTA KPNA1 HSALNG0028505
GH03J122073 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +487.4 487354 7.1 BCLAF1 SP1 CEBPA BCL11A SIN3A TRIM22 NR2C1 FOXA2 RXRA IRF4 CD86 ILDR1 ENSG00000202388 DTX3L PARP9 FAM162A MIX23 IQCB1 EAF2 CSTA
GH03J122773 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -209.4 -209357 1.8 TRIM22 SMARCA5 CTCF SPI1 ZNF24 NR2F1 PKNOX1 IKZF1 HLF TARDBP PARP14 HSPBAP1 DTX3L PARP9 SLC49A4 CSTA KPNA1 lnc-SEMA5B-2 piR-49732-420
GH03J122099 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +463.0 463001 5.2 BCLAF1 SP1 ZNF654 BCL11A CTCF REST ZNF592 TRIM22 ZNF217 RXRA CSTA CD86 ILDR1 ENSG00000202388 CASR POLQ PARP9 DTX3L HCLS1 EAF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP9

Top Transcription factor binding sites by QIAGEN in the PARP9 gene promoter:
  • AML1a
  • Bach1
  • C/EBPalpha
  • CBF(2)
  • CP2
  • FOXO1
  • FOXO1a
  • MZF-1
  • NF-Y
  • Nkx2-5

Genomic Locations for PARP9 Gene

Latest Assembly
chr3:122,527,924-122,564,784
(GRCh38/hg38)
Size:
36,861 bases
Orientation:
Minus strand

Previous Assembly
chr3:122,246,771-122,283,631
(GRCh37/hg19 by Entrez Gene)
Size:
36,861 bases
Orientation:
Minus strand

chr3:122,246,771-122,283,424
(GRCh37/hg19 by Ensembl)
Size:
36,654 bases
Orientation:
Minus strand

Genomic View for PARP9 Gene

Genes around PARP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP9 Gene

Proteins for PARP9 Gene

  • Protein details for PARP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXQ6-PARP9_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP9
    Protein Accession:
    Q8IXQ6
    Secondary Accessions:
    • A8KA94
    • B2R8S9
    • E9PFM7
    • Q8TCP3
    • Q9BZL8
    • Q9BZL9

    Protein attributes for PARP9 Gene

    Size:
    854 amino acids
    Molecular mass:
    96343 Da
    Quaternary structure:
    • Forms a stable complex with E3 ligase DTX3L; the interaction is required for PARP9 mediated ADP-ribosylation of ubiquitin (PubMed:12670957, PubMed:28525742). Interacts (via PARP catalytic domain) with DTX3L (via N-terminus) (PubMed:26479788). Forms a complex with STAT1 and DTX3L independently of IFNB1 or IFNG-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788). Forms a complex with STAT1, DTX3L and histone H2B H2BC9/H2BJ; the interaction is likely to induce H2BC9/H2BJ ubiquitination (PubMed:26479788). Interacts (via N-terminus) with STAT1 (PubMed:26479788). Interacts with PARP14 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP-riboslylation (PubMed:27796300). Interacts with PARP1 (when poly-ADP-ribosylated) (PubMed:23230272).

    Three dimensional structures from OCA and Proteopedia for PARP9 Gene

    Alternative splice isoforms for PARP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP9 Gene

Post-translational modifications for PARP9 Gene

No data available for DME Specific Peptides for PARP9 Gene

Domains & Families for PARP9 Gene

Gene Families for PARP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PARP9 Gene

InterPro:
Blocks:
  • Protein of unknown function Appr-1

Suggested Antigen Peptide Sequences for PARP9 Gene

GenScript: Design optimal peptide antigens:
  • B aggressive lymphoma protein (PARP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXQ6

UniProtKB/Swiss-Prot:

PARP9_HUMAN :
  • Macro domains 1 and 2 may be involved in the binding to poly(ADP-ribose) (PubMed:28525742, PubMed:26479788). Macro domain 2 is required for recruitment to DNA damage sites (PubMed:23230272). Macro domains 1 and 2 are probably dispensable for the interaction with STAT1 and DTX3L and for STAT1 phosphorylation (PubMed:26479788).
Domain:
  • Macro domains 1 and 2 may be involved in the binding to poly(ADP-ribose) (PubMed:28525742, PubMed:26479788). Macro domain 2 is required for recruitment to DNA damage sites (PubMed:23230272). Macro domains 1 and 2 are probably dispensable for the interaction with STAT1 and DTX3L and for STAT1 phosphorylation (PubMed:26479788).
genes like me logo Genes that share domains with PARP9: view

Function for PARP9 Gene

Molecular function for PARP9 Gene

UniProtKB/Swiss-Prot Function:
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide; Xref=Rhea:RHEA:58268, Rhea:RHEA-COMP:15093, Rhea:RHEA-COMP:15095, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:83148, ChEBI:CHEBI:142558; Evidence={ECO:0000269|PubMed:28525742};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG in macrophages and in B-cell lymphoma cell lines (PubMed:16809771, PubMed:27796300, PubMed:26479788). Up-regulated by IFNB1 or viral infection (PubMed:26479788). Down-regulated by IL4 in macrophages (PubMed:27796300).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=196 uM for NAD(+) {ECO:0000269|PubMed:28525742};
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to poly(ADP-ribose) does not affect its activity.

Enzyme Numbers (IUBMB) for PARP9 Gene

Phenotypes From GWAS Catalog for PARP9 Gene

Gene Ontology (GO) - Molecular Function for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IMP 16061477
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity IBA,IMP 16061477
GO:0004857 enzyme inhibitor activity IDA 27796300
GO:0005515 protein binding IPI 16809771
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PARP9: view
genes like me logo Genes that share phenotypes with PARP9: view

Animal Models for research

  • Taconic Biosciences Mouse Models for PARP9

miRNA for PARP9 Gene

miRTarBase miRNAs that target PARP9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP9

Clone products for research

  • Addgene plasmids for PARP9

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP9 Gene

Localization for PARP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP9 Gene

Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:16809771). Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742). {ECO:0000269 PubMed:16809771, ECO:0000269 PubMed:23230272, ECO:0000269 PubMed:26479788, ECO:0000269 PubMed:28525742}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP9 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 11110709
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 16809771
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PARP9: view

Pathways & Interactions for PARP9 Gene

genes like me logo Genes that share pathways with PARP9: view

Pathways by source for PARP9 Gene

Gene Ontology (GO) - Biological Process for PARP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 16061477
GO:0002230 positive regulation of defense response to virus by host IGI 26479788
GO:0002376 immune system process IEA --
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IMP 23230272
genes like me logo Genes that share ontologies with PARP9: view

No data available for SIGNOR curated interactions for PARP9 Gene

Drugs & Compounds for PARP9 Gene

(4) Drugs for PARP9 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP9 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP9 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP9: view

Transcripts for PARP9 Gene

mRNA/cDNA for PARP9 Gene

23 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP9

Clone products for research

  • Addgene plasmids for PARP9

Alternative Splicing Database (ASD) splice patterns (SP) for PARP9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for PARP9 Gene

GeneLoc Exon Structure for
PARP9

Expression for PARP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP9 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for PARP9 Gene

This gene is overexpressed in Lymph node (20.6), Spleen (6.9), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP9 Gene



Protein tissue co-expression partners for PARP9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP9

SOURCE GeneReport for Unigene cluster for PARP9 Gene:

Hs.518200

mRNA Expression by UniProt/SwissProt for PARP9 Gene:

Q8IXQ6-PARP9_HUMAN
Tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa (PubMed:11110709, PubMed:16809771). Expressed in macrophages (PubMed:27796300). Also expressed in nonhematopoietic tissues such as heart and skeletal muscle (PubMed:11110709, PubMed:16809771). Isoform 2 is the predominant form (PubMed:11110709). Most abundantly expressed in lymphomas with a brisk host inflammatory response (PubMed:11110709, PubMed:16809771). In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells (PubMed:11110709, PubMed:16809771).

Evidence on tissue expression from TISSUES for PARP9 Gene

  • Nervous system(4.4)
  • Blood(4.4)
  • Intestine(2.4)
  • Liver(2.2)
  • Spleen(2.2)
  • Lung(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with PARP9: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP9 Gene

Orthologs for PARP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP9 29 30
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP9 29 30
  • 79.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP9 29 30
  • 78.28 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp9 29 16 30
  • 74.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp9 29
  • 73.18 (n)
Oppossum
(Monodelphis domestica)
Mammalia PARP9 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PARP9 29 30
  • 51.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP9 30
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp9 29
  • 47.11 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-219a4.6 29
  • 50.02 (n)
PARP9 30
  • 32 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 24 (a)
OneToMany
Species where no ortholog for PARP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP9 Gene

ENSEMBL:
Gene Tree for PARP9 (if available)
TreeFam:
Gene Tree for PARP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP9: view image
Alliance of Genome Resources:
Additional Orthologs for PARP9

Paralogs for PARP9 Gene

Paralogs for PARP9 Gene

(2) SIMAP similar genes for PARP9 Gene using alignment to 3 proteins:

  • PARP9_HUMAN
  • C9K0E5_HUMAN
  • G5E9U8_HUMAN
genes like me logo Genes that share paralogs with PARP9: view

Variants for PARP9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP9 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
993731 Uncertain Significance: none provided 122,528,437(-) T/G
NM_001146105.2(PARP9):c.2387A>C (p.Tyr796Ser)
MISSENSE
994006 Uncertain Significance: none provided 122,528,439(-) A/T
NM_001146105.2(PARP9):c.2385T>A (p.Asp795Glu)
MISSENSE
995677 Uncertain Significance: none provided 122,540,585(-) A/G
NM_001146105.2(PARP9):c.1652T>C (p.Ile551Thr)
MISSENSE
rs146564634 Benign: not provided 122,550,697(-) C/T
NM_001146102.2(PARP9):c.1318G>A (p.Glu440Lys)
MISSENSE
rs6780543 Benign: not provided 122,536,993(-) T/Cp.Thr651Ala
NM_001146102.2(PARP9):c.1951A>G (p.Thr651Ala)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP9 Gene

Variant ID Type Subtype PubMed ID
esv2763295 CNV loss 21179565

Variation tolerance for PARP9 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP9
Leiden Open Variation Database (LOVD)
PARP9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP9 Gene

Disorders for PARP9 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PARP9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
b-cell lymphoma
  • b-cell lymphocytic neoplasm
lymphoma
  • lymphoid cancer
osebold-remondini syndrome
  • brachymesophalangy with mesomelic short limbs and carpal and tarsal osseous abnormalities
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
- elite association - COSMIC cancer census association via MalaCards
Search PARP9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PARP9_HUMAN
  • Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors (PubMed:11110709). {ECO:0000269 PubMed:11110709}.

Additional Disease Information for PARP9

genes like me logo Genes that share disorders with PARP9: view

No data available for Genatlas for PARP9 Gene

Publications for PARP9 Gene

  1. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. (PMID: 16809771) Juszczynski P … Shipp MA (Molecular and cellular biology 2006) 3 4 22
  2. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. (PMID: 11110709) Aguiar RC … Shipp MA (Blood 2000) 2 3 4
  3. Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. (PMID: 28525742) Yang CS … Paschal BM (Molecular cell 2017) 3 4
  4. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. (PMID: 27796300) Iwata H … Aikawa M (Nature communications 2016) 3 4
  5. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. (PMID: 26479788) Zhang Y … Holtzman MJ (Nature immunology 2015) 3 4

Products for PARP9 Gene

Sources for PARP9 Gene