Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 8 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP8 3 4
  • ARTD16 3 4
  • Poly [ADP-Ribose] Polymerase 8 4
  • EC 2.4.2.30 52
  • EC 2.4.2.- 4
  • PART16 3
  • PARP-8 4

External Ids for PARP8 Gene

Previous GeneCards Identifiers for PARP8 Gene

  • GC05P049998
  • GC05P046926
  • GC05P049961

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8) is a Protein Coding gene. Diseases associated with PARP8 include Epileptic Encephalopathy, Early Infantile, 24. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

UniProtKB/Swiss-Prot Summary for PARP8 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP8 Gene

Additional gene information for PARP8 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

GeneHancer (GH) Regulatory Elements for PARP8 Gene

Promoters and enhancers for PARP8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J050664 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 534.8 +1.7 1723 5.6 EP300 SIN3A SP1 ZFX ZNF639 ZIC2 POLR2A ZBTB10 ZNF423 ZBTB26 PARP8 HSALNG0041635 NONHSAG002815.2-006
GH05J050653 Enhancer 0.8 Ensembl ENCODE 35 -11.0 -10999 4.2 TRIM22 FOS MEF2B JUND SPI1 GATA3 ELF1 ZNF512B POLR2A ZNF366 PARP8 ENSG00000271752 piR-57133-476
GH05J050589 Enhancer 0.7 Ensembl ENCODE 39.3 -73.3 -73299 6.8 FOS MEF2B SPI1 JUND TCF7L2 TBX21 GATA3 IKZF1 MTA2 PKNOX1 PARP8 EMB lnc-PARP8-3 ENSG00000271455 L13714-370
GH05J050634 Promoter/Enhancer 0.6 Ensembl ENCODE 34 -30.9 -30938 1.5 POLR2A ENSG00000213956 LOC202319 piR-57133-476 PARP8
GH05J050647 Enhancer 0.6 Ensembl 35.1 -16.9 -16898 5.2 FOXA1 ZBTB17 SPI1 ZNF335 ZNF843 PRDM6 FEZF1 GATA3 ZNF384 ZNF362 PARP8 ENSG00000271752 piR-57133-476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP8

Top Transcription factor binding sites by QIAGEN in the PARP8 gene promoter:
  • AREB6
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • HEN1
  • Zic1

Genomic Locations for PARP8 Gene

Genomic Locations for PARP8 Gene
chr5:50,665,899-50,846,522
(GRCh38/hg38)
Size:
180,624 bases
Orientation:
Plus strand
chr5:49,961,733-50,142,356
(GRCh37/hg19)
Size:
180,624 bases
Orientation:
Plus strand

Genomic View for PARP8 Gene

Genes around PARP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3A8-PARP8_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP8
    Protein Accession:
    Q8N3A8
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    Size:
    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP8 Gene

Selected DME Specific Peptides for PARP8 Gene

Q8N3A8:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP8 Gene

Domains & Families for PARP8 Gene

Gene Families for PARP8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARP8 Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 8 (PARP8_HUMAN)
  • PARP8 protein (Q49AI7_HUMAN)
genes like me logo Genes that share domains with PARP8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP8 Gene

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56613; Evidence=. ;.

Enzyme Numbers (IUBMB) for PARP8 Gene

Phenotypes From GWAS Catalog for PARP8 Gene

Gene Ontology (GO) - Molecular Function for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0019900 kinase binding IBA 21873635
GO:0043539 protein serine/threonine kinase activator activity IBA 21873635
genes like me logo Genes that share ontologies with PARP8: view
genes like me logo Genes that share phenotypes with PARP8: view

Animal Models for PARP8 Gene

MGI Knock Outs for PARP8:
  • Parp8 Parp8<tm1.1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for PARP8 Gene

miRTarBase miRNAs that target PARP8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP8

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Midbody ring (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005635 nuclear envelope IBA 21873635
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0071782 endoplasmic reticulum tubular network IBA 21873635
genes like me logo Genes that share ontologies with PARP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PARP8 Gene

Pathways & Interactions for PARP8 Gene

genes like me logo Genes that share pathways with PARP8: view

Interacting Proteins for PARP8 Gene

Selected Interacting proteins: Q8N3A8-PARP8_HUMAN for PARP8 Gene via IID

;

Gene Ontology (GO) - Biological Process for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IBA 21873635
GO:0030968 endoplasmic reticulum unfolded protein response IBA 21873635
GO:0070213 protein auto-ADP-ribosylation IDA 25043379
GO:0071902 positive regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with PARP8: view

No data available for SIGNOR curated interactions for PARP8 Gene

Drugs & Compounds for PARP8 Gene

(4) Drugs for PARP8 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 526,526
NAD Experimental Pharma Full agonist, Agonist, Activator 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

mRNA/cDNA for PARP8 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
PARP8

Expression for PARP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for PARP8 Gene

This gene is overexpressed in Monocytes (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP8 Gene



Protein tissue co-expression partners for PARP8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP8

SOURCE GeneReport for Unigene cluster for PARP8 Gene:

Hs.369581

Evidence on tissue expression from TISSUES for PARP8 Gene

  • Intestine(4.3)
  • Muscle(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with PARP8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP8 Gene

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP8 31 30
  • 99.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PARP8 31 30
  • 93.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PARP8 31 30
  • 92.78 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP8 31
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP8 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp8 17 31 30
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Parp8 30
  • 89.14 (n)
chicken
(Gallus gallus)
Aves PARP8 31 30
  • 85.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP8 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia parp8 30
  • 82.96 (n)
zebrafish
(Danio rerio)
Actinopterygii parp8 31 30
  • 74.37 (n)
OneToOne
Dr.25837 30
Species where no ortholog for PARP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

ENSEMBL:
Gene Tree for PARP8 (if available)
TreeFam:
Gene Tree for PARP8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP8: view image

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene

(3) SIMAP similar genes for PARP8 Gene using alignment to 15 proteins:

  • PARP8_HUMAN
  • D6R914_HUMAN
  • D6R9T2_HUMAN
  • D6RAL6_HUMAN
  • D6RB30_HUMAN
  • D6RC81_HUMAN
  • D6RCA6_HUMAN
  • D6RCN2_HUMAN
  • D6RF37_HUMAN
  • D6RF59_HUMAN
  • D6RFH0_HUMAN
  • D6RGZ9_HUMAN
  • E9PFI7_HUMAN
  • F5H3X8_HUMAN
  • Q49AI7_HUMAN

Pseudogenes.org Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP8 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_035853 A colorectal cancer sample p.Ser777Ala

Additional dbSNP identifiers (rs#s) for PARP8 Gene

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
dgv5665n100 CNV gain 25217958
dgv702n27 CNV loss 19166990
dgv9773n54 CNV loss 21841781
dgv9774n54 CNV loss 21841781
esv21955 CNV gain 19812545
esv2759342 CNV gain 17122850
esv3605029 CNV gain 21293372
esv3894187 CNV loss 25118596
nsv1114682 CNV deletion 24896259
nsv1133599 CNV deletion 24896259
nsv462163 CNV loss 19166990
nsv462164 CNV loss 19166990
nsv471838 CNV novel sequence insertion 20440878
nsv507252 OTHER sequence alteration 20534489
nsv521214 CNV loss 19592680
nsv523212 CNV gain 19592680
nsv598108 CNV gain 21841781
nsv598115 CNV loss 21841781
nsv598116 CNV gain 21841781
nsv818352 CNV loss 17921354
nsv819124 CNV loss 19587683
nsv950692 CNV duplication 24416366
nsv965013 CNV duplication 23825009
nsv968172 CNV duplication 23825009
nsv968910 CNV duplication 23825009
nsv980791 CNV duplication 23825009

Variation tolerance for PARP8 Gene

Residual Variation Intolerance Score: 6.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP8 Gene

Human Gene Mutation Database (HGMD)
PARP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP8 Gene

Disorders for PARP8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PARP8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 24
  • eiee24
- elite association - COSMIC cancer census association via MalaCards
Search PARP8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARP8

genes like me logo Genes that share disorders with PARP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP8 Gene

Publications for PARP8 Gene

  1. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 54
  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 54

Products for PARP8 Gene

Sources for PARP8 Gene