Aliases for PARP8 Gene

Aliases for PARP8 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 8 2 3 5
  • ARTD16 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 16 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP8 3 4
  • PART16 2 3
  • Poly [ADP-Ribose] Polymerase 8 4
  • EC 2.4.2.30 50
  • EC 2.4.2.- 4
  • FLJ21308 2
  • PARP-8 4
  • PARP8 5

External Ids for PARP8 Gene

Previous GeneCards Identifiers for PARP8 Gene

  • GC05P049998
  • GC05P046926
  • GC05P049961

Summaries for PARP8 Gene

GeneCards Summary for PARP8 Gene

PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8) is a Protein Coding gene. Diseases associated with PARP8 include Developmental And Epileptic Encephalopathy 24 and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP6.

UniProtKB/Swiss-Prot Summary for PARP8 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Tocris Summary for PARP8 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP8 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP8 Gene

Genomics for PARP8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J050664 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 284.8 +1.8 1791 5.6 SP1 ZNF207 ZNF600 POLR2A CEBPA ZIC2 ZBTB10 YY1 CEBPB ZNF592 PARP8 HSALNG0041635 HSALNG0041636 HSALNG0041634 NONHSAG002815.2-006 ISL1
GH05J050653 Enhancer 0.8 Ensembl ENCODE 35 -11.0 -11031 4.4 JUND TRIM22 BHLHE40 SPI1 MYC MAX POLR2A ZNF512B ELF1 ZNF547 PARP8 ENSG00000271752 HSALNG0041629 HSALNG0041624 EMB
GH05J050590 Enhancer 0.7 Ensembl ENCODE 39.3 -73.5 -73530 7.4 TCF7L2 JUND SPI1 PKNOX1 IKZF1 MTA2 EP300 FOS SCRT2 MLLT1 PARP8 EMB HSALNG0041623 L13714-369
GH05J050634 Promoter/Enhancer 0.6 Ensembl ENCODE 34 -30.9 -30870 1.5 POLR2A ENSG00000213956 LOC202319 piR-57133-476 PARP8 HSALNG0041629 HSALNG0041624 EMB
GH05J050647 Enhancer 0.6 Ensembl 35.1 -16.8 -16830 5.2 FEZF1 ZNF843 PRDM6 SPI1 ZNF362 ZNF384 PKNOX1 FOXA1 ZBTB17 ZNF335 PARP8 HSALNG0041629 ENSG00000271752 HSALNG0041624 EMB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP8

Top Transcription factor binding sites by QIAGEN in the PARP8 gene promoter:
  • AREB6
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • HEN1
  • Zic1

Genomic Locations for PARP8 Gene

Latest Assembly
chr5:50,665,831-50,846,522
(GRCh38/hg38)
Size:
180,692 bases
Orientation:
Plus strand

Previous Assembly
chr5:49,961,765-50,142,353
(GRCh37/hg19 by Entrez Gene)
Size:
180,589 bases
Orientation:
Plus strand

chr5:49,961,733-50,142,356
(GRCh37/hg19 by Ensembl)
Size:
180,624 bases
Orientation:
Plus strand

Genomic View for PARP8 Gene

Genes around PARP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP8 Gene

Proteins for PARP8 Gene

  • Protein details for PARP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3A8-PARP8_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP8
    Protein Accession:
    Q8N3A8
    Secondary Accessions:
    • Q3KRB7
    • Q6DHZ1
    • Q9H754

    Protein attributes for PARP8 Gene

    Size:
    854 amino acids
    Molecular mass:
    95871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI05790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP8 Gene

Selected DME Specific Peptides for PARP8 Gene

Q8N3A8:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP8 Gene

Domains & Families for PARP8 Gene

Gene Families for PARP8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP8 Gene

Suggested Antigen Peptide Sequences for PARP8 Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 8 (PARP8_HUMAN)
  • PARP8 protein (Q49AI7_HUMAN)
genes like me logo Genes that share domains with PARP8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP8 Gene

Function for PARP8 Gene

Molecular function for PARP8 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence={ECO:0000269|PubMed:25043379};.

Enzyme Numbers (IUBMB) for PARP8 Gene

Phenotypes From GWAS Catalog for PARP8 Gene

Gene Ontology (GO) - Molecular Function for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:1990404 protein ADP-ribosylase activity IDA 25043379
genes like me logo Genes that share ontologies with PARP8: view
genes like me logo Genes that share phenotypes with PARP8: view

Animal Models for PARP8 Gene

MGI Knock Outs for PARP8:
  • Parp8 Parp8<tm1.1(KOMP)Wtsi>

miRNA for PARP8 Gene

miRTarBase miRNAs that target PARP8

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP8

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP8 Gene

Localization for PARP8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP8 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Midbody ring (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
genes like me logo Genes that share ontologies with PARP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PARP8 Gene

Pathways & Interactions for PARP8 Gene

genes like me logo Genes that share pathways with PARP8: view

Pathways by source for PARP8 Gene

4 Qiagen pathways for PARP8 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Interacting Proteins for PARP8 Gene

Selected Interacting proteins: Q8N3A8-PARP8_HUMAN for PARP8 Gene via IID

Gene Ontology (GO) - Biological Process for PARP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IBA 21873635
GO:0070213 protein auto-ADP-ribosylation IDA 25043379
genes like me logo Genes that share ontologies with PARP8: view

No data available for SIGNOR curated interactions for PARP8 Gene

Drugs & Compounds for PARP8 Gene

(4) Drugs for PARP8 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP8 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP8: view

Transcripts for PARP8 Gene

mRNA/cDNA for PARP8 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP8

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PARP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PARP8 Gene

GeneLoc Exon Structure for
PARP8

Expression for PARP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARP8 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for PARP8 Gene

This gene is overexpressed in Monocytes (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP8 Gene



Protein tissue co-expression partners for PARP8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP8

SOURCE GeneReport for Unigene cluster for PARP8 Gene:

Hs.369581

Evidence on tissue expression from TISSUES for PARP8 Gene

  • Intestine(4.3)
  • Pancreas(4.1)
  • Muscle(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with PARP8: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP8 Gene

Orthologs for PARP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP8 29 30
  • 99.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP8 29 30
  • 93.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP8 29 30
  • 92.78 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PARP8 30
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PARP8 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp8 29 16 30
  • 89.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp8 29
  • 89.14 (n)
Chicken
(Gallus gallus)
Aves PARP8 29 30
  • 85.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP8 30
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp8 29
  • 82.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii parp8 29 30
  • 74.37 (n)
OneToOne
Dr.25837 29
Species where no ortholog for PARP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP8 Gene

ENSEMBL:
Gene Tree for PARP8 (if available)
TreeFam:
Gene Tree for PARP8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP8: view image
Alliance of Genome Resources:
Additional Orthologs for PARP8

Paralogs for PARP8 Gene

Paralogs for PARP8 Gene

(3) SIMAP similar genes for PARP8 Gene using alignment to 15 proteins:

  • PARP8_HUMAN
  • D6R914_HUMAN
  • D6R9T2_HUMAN
  • D6RAL6_HUMAN
  • D6RB30_HUMAN
  • D6RC81_HUMAN
  • D6RCA6_HUMAN
  • D6RCN2_HUMAN
  • D6RF37_HUMAN
  • D6RF59_HUMAN
  • D6RFH0_HUMAN
  • D6RGZ9_HUMAN
  • E9PFI7_HUMAN
  • F5H3X8_HUMAN
  • Q49AI7_HUMAN

Pseudogenes.org Pseudogenes for PARP8 Gene

genes like me logo Genes that share paralogs with PARP8: view

Variants for PARP8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP8 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_035853 A colorectal cancer sample p.Ser777Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP8 Gene

Variant ID Type Subtype PubMed ID
dgv5665n100 CNV gain 25217958
dgv702n27 CNV loss 19166990
dgv9773n54 CNV loss 21841781
dgv9774n54 CNV loss 21841781
esv21955 CNV gain 19812545
esv2759342 CNV gain 17122850
esv3605029 CNV gain 21293372
esv3894187 CNV loss 25118596
nsv1114682 CNV deletion 24896259
nsv1133599 CNV deletion 24896259
nsv462163 CNV loss 19166990
nsv462164 CNV loss 19166990
nsv471838 CNV novel sequence insertion 20440878
nsv507252 OTHER sequence alteration 20534489
nsv521214 CNV loss 19592680
nsv523212 CNV gain 19592680
nsv598108 CNV gain 21841781
nsv598115 CNV loss 21841781
nsv598116 CNV gain 21841781
nsv818352 CNV loss 17921354
nsv819124 CNV loss 19587683
nsv950692 CNV duplication 24416366
nsv965013 CNV duplication 23825009
nsv968172 CNV duplication 23825009
nsv968910 CNV duplication 23825009
nsv980791 CNV duplication 23825009

Variation tolerance for PARP8 Gene

Residual Variation Intolerance Score: 6.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP8 Gene

Human Gene Mutation Database (HGMD)
PARP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP8
Leiden Open Variation Database (LOVD)
PARP8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP8 Gene

Disorders for PARP8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP8 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search PARP8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARP8

genes like me logo Genes that share disorders with PARP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP8 Gene

Publications for PARP8 Gene

  1. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. (PMID: 28298427) Sokolina K … Stagljar I (Molecular systems biology 2017) 3

Products for PARP8 Gene

Sources for PARP8 Gene