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Aliases for PARP6 Gene

Aliases for PARP6 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 6 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 17 3 4
  • EC 4 56
  • ARTD17 3 4
  • PARP-6 3 4
  • Poly [ADP-Ribose] Polymerase 6 3
  • PARP-6-B1 3
  • PARP-6-C 3
  • PART17 3

External Ids for PARP6 Gene

Previous GeneCards Identifiers for PARP6 Gene

  • GC15M070320
  • GC15M072533
  • GC15M049364

Summaries for PARP6 Gene

GeneCards Summary for PARP6 Gene

PARP6 (Poly(ADP-Ribose) Polymerase Family Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP8.

Tocris Summary for PARP6 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP6 Gene

Genomics for PARP6 Gene

GeneHancer (GH) Regulatory Elements for PARP6 Gene

Promoters and enhancers for PARP6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I072271 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.7 +0.4 395 3.1 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 ZBTB7B YY1 POLR2B ZNF213 PARP6 MYO9A TMEM202-AS1 ARIH1 ENSG00000261187 LOC105370887 PKM GRAMD2A ENSG00000260672 ADPGK
GH15I072471 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.7 -201.0 -200962 5.6 CLOCK MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ARIH1 TMEM202-AS1 ENSG00000261187 HEXA PARP6 LOC105370887 BBS4 MYO9A ENSG00000260672 CELF6
GH15I072116 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 28.8 +154.8 154819 4 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 MYO9A SENP8 CELF6 ENSG00000261187 PARP6 RPL17P39 BBS4 ARIH1 TMEM202-AS1 ENSG00000260672
GH15I072225 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.8 +43.7 43747 8 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 SLC30A9 ZNF213 E2F8 ZNF416 PKM ENSG00000261187 LOC105370887 HEXA MYO9A TMEM202-AS1 ARIH1 ADPGK CELF6 RPL17P39
GH15I072194 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.9 +73.5 73479 9.6 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF48 POLR2B GLIS2 GRAMD2A PARP6 ENSG00000261187 LOC105370887 RPL17P39 HEXA CELF6 PKM TMEM202-AS1 ARIH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PARP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARP6 gene promoter:

Genomic Locations for PARP6 Gene

Genomic Locations for PARP6 Gene
31,819 bases
Minus strand

Genomic View for PARP6 Gene

Genes around PARP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP6 Gene

Proteins for PARP6 Gene

  • Protein details for PARP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 6
    Protein Accession:
    Secondary Accessions:
    • Q9H7C5
    • Q9H9X6
    • Q9HAF3
    • Q9NPS6
    • Q9UFG4

    Protein attributes for PARP6 Gene

    630 amino acids
    Molecular mass:
    71115 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB59261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP6 Gene


neXtProt entry for PARP6 Gene

Selected DME Specific Peptides for PARP6 Gene


Post-translational modifications for PARP6 Gene

No Post-translational modifications

Domains & Families for PARP6 Gene

Gene Families for PARP6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP6 Gene

Suggested Antigen Peptide Sequences for PARP6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP6: view

No data available for UniProtKB/Swiss-Prot for PARP6 Gene

Function for PARP6 Gene

Molecular function for PARP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP6 Gene

Phenotypes From GWAS Catalog for PARP6 Gene

Gene Ontology (GO) - Molecular Function for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP6: view
genes like me logo Genes that share phenotypes with PARP6: view

Animal Model Products

CRISPR Products

miRNA for PARP6 Gene

miRTarBase miRNAs that target PARP6

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP6 Gene

Localization for PARP6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP6 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PARP6 Gene

Pathways & Interactions for PARP6 Gene

genes like me logo Genes that share pathways with PARP6: view

Gene Ontology (GO) - Biological Process for PARP6 Gene


No data available for SIGNOR curated interactions for PARP6 Gene

Drugs & Compounds for PARP6 Gene

(11) Drugs for PARP6 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Nutra 942,946
AG-14361 Pharma Potent PARP1 inhibitor 0
Iniparib (BSI-201) Pharma PARP1 inhibitor,intravenously adminsitered 0
INO-1001 Pharma Potent PARP inhibitor 0
ME0328 Pharma PARP inhibitor,potent and selective 0

(1) Additional Compounds for PARP6 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for PARP6 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2

(5) ApexBio Compounds for PARP6 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP6: view

Drug Products

Transcripts for PARP6 Gene

Unigene Clusters for PARP6 Gene

Poly (ADP-ribose) polymerase family, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^
SP1: -
SP2: - -
SP3: -
SP4: -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP10: - - - -
SP11: - -
SP13: - - - -
SP14: - - - -
SP16: - -
SP17: - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ·
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP12: -
SP15: - - - - - - - - - - - - - - - - -

Relevant External Links for PARP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP6 Gene:


SOURCE GeneReport for Unigene cluster for PARP6 Gene:


Evidence on tissue expression from TISSUES for PARP6 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with PARP6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP6 Gene

Orthologs for PARP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia PARP6 34
  • 99 (a)
(Canis familiaris)
Mammalia PARP6 33 34
  • 96.61 (n)
(Pan troglodytes)
Mammalia PARP6 33 34
  • 95.88 (n)
(Mus musculus)
Mammalia Parp6 33 16 34
  • 94.81 (n)
(Rattus norvegicus)
Mammalia Parp6 33
  • 94.23 (n)
(Ornithorhynchus anatinus)
Mammalia PARP6 34
  • 93 (a)
(Bos Taurus)
Mammalia PARP6 34
  • 80 (a)
(Gallus gallus)
Aves PARP6 33 34
  • 84.03 (n)
(Anolis carolinensis)
Reptilia PARP6 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia parp6 33
  • 77.18 (n)
Str.11258 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17912 33
(Danio rerio)
Actinopterygii PARP6 (3 of 4) 34
  • 96 (a)
PARP6 (4 of 4) 34
  • 80 (a)
parp6a 34
  • 80 (a)
parp6b 34
  • 80 (a)
LOC100329514 33
  • 73.5 (n)
Dr.15239 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6240 33
Species where no ortholog for PARP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP6 Gene

Gene Tree for PARP6 (if available)
Gene Tree for PARP6 (if available)

Paralogs for PARP6 Gene

Paralogs for PARP6 Gene

genes like me logo Genes that share paralogs with PARP6: view

Variants for PARP6 Gene

Sequence variations from dbSNP and Humsavar for PARP6 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000060414 -- 72,271,504(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000182470 -- 72,244,705(-) C/T intron_variant
rs1000228961 -- 72,258,976(-) G/A intron_variant
rs1000281 -- 72,261,081(-) T/C intron_variant
rs1000486002 -- 72,254,087(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PARP6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV deletion 18451855

Variation tolerance for PARP6 Gene

Residual Variation Intolerance Score: 8.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP6 Gene

Disorders for PARP6 Gene

Additional Disease Information for PARP6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PARP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP6 Gene

Publications for PARP6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells. (PMID: 28260087) Wang H … Zhu X (Oncology reports 2017) 3 58

Products for PARP6 Gene

Sources for PARP6 Gene

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