Aliases for PARP6 Gene

Aliases for PARP6 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 6 2 3 5
  • ARTD17 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 17 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP6 3 4
  • Poly [ADP-Ribose] Polymerase 6 3 4
  • PART17 2 3
  • PARP-6 3 4
  • EC 2.4.2.30 50
  • EC 2.4.2.- 4
  • PARP-6-B1 3
  • PARP-6-C 3
  • PARP6 5

External Ids for PARP6 Gene

Previous GeneCards Identifiers for PARP6 Gene

  • GC15M070320
  • GC15M072533
  • GC15M049364

Summaries for PARP6 Gene

GeneCards Summary for PARP6 Gene

PARP6 (Poly(ADP-Ribose) Polymerase Family Member 6) is a Protein Coding gene. Diseases associated with PARP6 include Porokeratosis. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP8.

UniProtKB/Swiss-Prot Summary for PARP6 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Tocris Summary for PARP6 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP6 Gene

Genomics for PARP6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J072271 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 257.6 +0.5 534 3.3 BCLAF1 SP1 NCOR1 IKZF1 MYC ZNF600 ZNF580 ZNF592 POLR2A ZNF10 PARP6 HSALNG0107051 lnc-CELF6-3 TMEM202-AS1 ARIH1 ENSG00000261187 PKM ENSG00000261460 GRAMD2A ENSG00000260672
GH15J072471 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 39.7 -201.3 -201271 6.3 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 JUND ZNF580 ZNF592 ARIH1 TMEM202-AS1 HSALNG0107062 ENSG00000261187 PARP6 ENSG00000261460 HEXA BBS4 MYO9A ENSG00000260672
GH15J072274 Enhancer 0.3 Ensembl 250.7 -1.3 -1302 0.2 HDGF ARID3A PARP6 lnc-CELF6-3 CELF6 PKM GRAMD2A MYO9A ENSG00000261460 ENSG00000273025 MK280269-017
GH15J072267 Promoter 0.3 EPDnew 250.4 +5.5 5457 0.1 piR-50444-133 PARP6 PKM GRAMD2A CELF6 lnc-PKM-2 ENSG00000273025 MK280269-017
GH15J072265 Promoter 0.3 EPDnew 250.4 +7.0 6991 0.1 PARP6 PKM GRAMD2A CELF6 piR-50444-133 lnc-PKM-2 MK280269-017
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP6

Top Transcription factor binding sites by QIAGEN in the PARP6 gene promoter:
  • FOXD3
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HNF-4alpha1
  • Max1
  • Nkx2-5
  • ZID

Genomic Locations for PARP6 Gene

Latest Assembly
chr15:72,241,181-72,272,999
(GRCh38/hg38)
Size:
31,819 bases
Orientation:
Minus strand

Previous Assembly
chr15:72,533,522-72,564,895
(GRCh37/hg19 by Entrez Gene)
Size:
31,374 bases
Orientation:
Minus strand

chr15:72,533,522-72,565,340
(GRCh37/hg19 by Ensembl)
Size:
31,819 bases
Orientation:
Minus strand

Genomic View for PARP6 Gene

Genes around PARP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP6 Gene

Proteins for PARP6 Gene

  • Protein details for PARP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL67-PARP6_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP6
    Protein Accession:
    Q2NL67
    Secondary Accessions:
    • Q9H7C5
    • Q9H9X6
    • Q9HAF3
    • Q9NPS6
    • Q9UFG4

    Protein attributes for PARP6 Gene

    Size:
    630 amino acids
    Molecular mass:
    71115 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB59261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PARP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP6 Gene

Selected DME Specific Peptides for PARP6 Gene

Q2NL67:
  • DHVCTRFFFVYEDGQVGDANINTQ
  • GSTFAFHGSHIENWHSILRNGLV
  • IFEPYPSVVDP
  • SIREMTQ
  • HQFLLLSSPPAKE
  • SSISFGYSGM
  • LNEYCVVCDE
  • DPLAHPLLQW
  • CIALCEVITS
  • YLEIKKQMDK
  • ISSNRSHIVKLP

Post-translational modifications for PARP6 Gene

Domains & Families for PARP6 Gene

Gene Families for PARP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP6 Gene

Suggested Antigen Peptide Sequences for PARP6 Gene

GenScript: Design optimal peptide antigens:
  • PARP6 protein (A0PJ50_HUMAN)
  • Poly [ADP-ribose] polymerase 6 (PARP6_HUMAN)
  • PARP6 protein (Q0VDG0_HUMAN)
genes like me logo Genes that share domains with PARP6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP6 Gene

Function for PARP6 Gene

Molecular function for PARP6 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence={ECO:0000269|PubMed:25043379};.

Enzyme Numbers (IUBMB) for PARP6 Gene

Phenotypes From GWAS Catalog for PARP6 Gene

Gene Ontology (GO) - Molecular Function for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:1990404 protein ADP-ribosylase activity IDA 25043379
genes like me logo Genes that share ontologies with PARP6: view
genes like me logo Genes that share phenotypes with PARP6: view

miRNA for PARP6 Gene

miRTarBase miRNAs that target PARP6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP6 Gene

Localization for PARP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP6 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
genes like me logo Genes that share ontologies with PARP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PARP6 Gene

Pathways & Interactions for PARP6 Gene

genes like me logo Genes that share pathways with PARP6: view

Pathways by source for PARP6 Gene

4 Qiagen pathways for PARP6 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IBA 21873635
GO:0050775 positive regulation of dendrite morphogenesis IEA --
GO:0070213 protein auto-ADP-ribosylation IDA 25043379
genes like me logo Genes that share ontologies with PARP6: view

No data available for SIGNOR curated interactions for PARP6 Gene

Drugs & Compounds for PARP6 Gene

(9) Drugs for PARP6 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
INO-1001 Investigational Pharma Potent PARP inhibitor 0
AG-14361 Pharma Potent PARP1 inhibitor 0

(1) Additional Compounds for PARP6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP6 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2

(5) ApexBio Compounds for PARP6 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP6: view

Drug products for research

Transcripts for PARP6 Gene

mRNA/cDNA for PARP6 Gene

15 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP6

Alternative Splicing Database (ASD) splice patterns (SP) for PARP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - -
SP15:
SP16: - -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ·
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PARP6 Gene

GeneLoc Exon Structure for
PARP6

Expression for PARP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP6

SOURCE GeneReport for Unigene cluster for PARP6 Gene:

Hs.270244

Evidence on tissue expression from TISSUES for PARP6 Gene

  • Nervous system(4.8)
  • Kidney(4.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with PARP6: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP6 Gene

Orthologs for PARP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP6 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia PARP6 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP6 29 30
  • 96.61 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia PARP6 29 30
  • 95.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp6 29 16 30
  • 94.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp6 29
  • 94.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PARP6 30
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP6 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PARP6 29 30
  • 84.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP6 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp6 29
  • 77.18 (n)
Str.11258 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.17912 29
Zebrafish
(Danio rerio)
Actinopterygii PARP6 (3 of 4) 30
  • 96 (a)
OneToMany
parp6a 30
  • 80 (a)
OneToMany
PARP6 (4 of 4) 30
  • 80 (a)
OneToMany
parp6b 30
  • 80 (a)
OneToMany
LOC100329514 29
  • 73.5 (n)
Dr.15239 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6240 29
Species where no ortholog for PARP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP6 Gene

ENSEMBL:
Gene Tree for PARP6 (if available)
TreeFam:
Gene Tree for PARP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP6: view image
Alliance of Genome Resources:
Additional Orthologs for PARP6

Paralogs for PARP6 Gene

Paralogs for PARP6 Gene

(2) SIMAP similar genes for PARP6 Gene using alignment to 17 proteins:

  • PARP6_HUMAN
  • A0PJ50_HUMAN
  • F5H3B4_HUMAN
  • H3BMA3_HUMAN
  • H3BQ70_HUMAN
  • H3BQK2_HUMAN
  • H3BQM7_HUMAN
  • H3BRR4_HUMAN
  • H3BRZ3_HUMAN
  • H3BSK7_HUMAN
  • H3BTE2_HUMAN
  • H3BTI3_HUMAN
  • H3BUQ6_HUMAN
  • H3BUY2_HUMAN
  • L8EB14_HUMAN
  • Q0VDG0_HUMAN
  • Q9NPQ9_HUMAN
genes like me logo Genes that share paralogs with PARP6: view

Variants for PARP6 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV deletion 18451855

Variation tolerance for PARP6 Gene

Residual Variation Intolerance Score: 8.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP6
Leiden Open Variation Database (LOVD)
PARP6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP6 Gene

Disorders for PARP6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PARP6 Gene - From: COP

Disorder Aliases PubMed IDs
porokeratosis
  • disseminated superficial actinic porokeratosis
- elite association - COSMIC cancer census association via MalaCards
Search PARP6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARP6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PARP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP6 Gene

Publications for PARP6 Gene

  1. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3

Products for PARP6 Gene

Sources for PARP6 Gene