Aliases for PARP4 Gene
- Poly(ADP-Ribose) Polymerase Family Member 4 2 3 5
- Vault Poly(ADP-Ribose) Polymerase 2 3 4
- ARTD4 2 3 4
- VPARP 2 3 4
- ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 1 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 4 3 4
- Von Willebrand Factor A Domain Containing 5C 2 3
- PARP-Related/IalphaI-Related H5/Proline-Rich 3 4
- Protein Mono-ADP-Ribosyltransferase PARP4 3 4
- Poly [ADP-Ribose] Polymerase 4 3 4
- 193 KDa Vault Protein 3 4
- ADPRTL1 3 4
- PARP-4 3 4
External Ids for PARP4 Gene
Previous HGNC Symbols for PARP4 Gene
Previous GeneCards Identifiers for PARP4 Gene
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP4 Gene
PARP4 (Poly(ADP-Ribose) Polymerase Family Member 4) is a Protein Coding gene. Diseases associated with PARP4 include Osebold-Remondini Syndrome and Cardia Cancer. Among its related pathways are Apoptosis Modulation and Signaling and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is VWA5B1.
UniProtKB/Swiss-Prot Summary for PARP4 Gene
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.