Aliases for PARP3 Gene
- Poly(ADP-Ribose) Polymerase Family Member 3 2 3 5
- PADPRT-3 2 3 4
- ADPRT3 2 3 4
- ARTD3 2 3 4
- IRT1 2 3 4
- ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 3 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 3 3 4
- Protein Mono-ADP-Ribosyltransferase PARP3 3 4
- DNA ADP-Ribosyltransferase PARP3 3 4
- NAD(+) ADP-Ribosyltransferase 3 3 4
- Poly [ADP-Ribose] Polymerase 3 3 4
- Poly(ADP-Ribose) Synthetase-3 2 3
External Ids for PARP3 Gene
Previous HGNC Symbols for PARP3 Gene
Previous GeneCards Identifiers for PARP3 Gene
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP3 Gene
PARP3 (Poly(ADP-Ribose) Polymerase Family Member 3) is a Protein Coding gene. Diseases associated with PARP3 include Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Apoptosis Modulation and Signaling and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP2.
UniProtKB/Swiss-Prot Summary for PARP3 Gene
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.