Aliases for PARP3 Gene
- Poly(ADP-Ribose) Polymerase Family Member 3 2 3 5
- ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 3 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 3 3 4
- NAD(+) ADP-Ribosyltransferase 3 3 4
- NAD+ ADP-Ribosyltransferase 3 2 3
- Poly(ADP-Ribose) Synthetase-3 2 3
- Poly[ADP-Ribose] Synthase 3 3 4
- PADPRT-3 3 4
- ADPRTL3 3 4
- ADPRT-3 3 4
- ADPRT3 3 4
External Ids for PARP3 Gene
Previous HGNC Symbols for PARP3 Gene
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP3 Gene
PARP3 (Poly(ADP-Ribose) Polymerase Family Member 3) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP2.
UniProtKB/Swiss-Prot for PARP3 Gene
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.