The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spl... See more...

Aliases for PARP3 Gene

Aliases for PARP3 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 3 2 3 5
  • PADPRT-3 2 3 4
  • ADPRT3 2 3 4
  • ARTD3 2 3 4
  • IRT1 2 3 4
  • ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 3 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 3 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP3 3 4
  • DNA ADP-Ribosyltransferase PARP3 3 4
  • NAD(+) ADP-Ribosyltransferase 3 3 4
  • Poly [ADP-Ribose] Polymerase 3 3 4
  • Poly(ADP-Ribose) Synthetase-3 2 3
  • NAD+ ADP-Ribosyltransferase 3 2 3
  • Poly[ADP-Ribose] Synthase 3 3 4
  • ADPRTL3 3 4
  • ADPRT-3 3 4
  • HPARP-3 2 4
  • ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 2 3
  • Poly(ADP-Ribose) Polymerase 3 2
  • Poly[ADP-Ribose] Synthetase 3 3
  • EC 2.4.2.- 4
  • ADPRTL2 3
  • PARP-3 4
  • PARP3 5

External Ids for PARP3 Gene

Previous HGNC Symbols for PARP3 Gene

  • ADPRTL3

Previous GeneCards Identifiers for PARP3 Gene

  • GC03P051951
  • GC03P051962

Summaries for PARP3 Gene

Entrez Gene Summary for PARP3 Gene

  • The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARP3 Gene

PARP3 (Poly(ADP-Ribose) Polymerase Family Member 3) is a Protein Coding gene. Diseases associated with PARP3 include Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Apoptosis Modulation and Signaling and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP2.

UniProtKB/Swiss-Prot Summary for PARP3 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity).

Tocris Summary for PARP3 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP3 Gene

Genomics for PARP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP3

Top Transcription factor binding sites by QIAGEN in the PARP3 gene promoter:
  • AML1a
  • AP-4
  • Arnt
  • ARP-1
  • Brachyury
  • c-Ets-1
  • GATA-2
  • HOXA3
  • Max1
  • RFX1

Genomic Locations for PARP3 Gene

Latest Assembly
chr3:51,942,290-51,948,867
(GRCh38/hg38)
Size:
6,578 bases
Orientation:
Plus strand

Previous Assembly
chr3:51,976,379-51,982,883
(GRCh37/hg19 by Entrez Gene)
Size:
6,505 bases
Orientation:
Plus strand

chr3:51,976,361-51,982,883
(GRCh37/hg19 by Ensembl)
Size:
6,523 bases
Orientation:
Plus strand

Genomic View for PARP3 Gene

Genes around PARP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP3 Gene

Proteins for PARP3 Gene

  • Protein details for PARP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F1-PARP3_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP3
    Protein Accession:
    Q9Y6F1
    Secondary Accessions:
    • Q8NER9
    • Q96CG2
    • Q9UG81

    Protein attributes for PARP3 Gene

    Size:
    533 amino acids
    Molecular mass:
    60089 Da
    Quaternary structure:
    • Interacts with PARP1; leading to activate PARP1 in absence of DNA (PubMed:16924674, PubMed:20064938). Interacts with PRKDC (PubMed:16924674). Interacts with XRCC5/Ku80; the interaction is dependent on nucleic acids (PubMed:16924674, PubMed:24598253). Interacts with XRCC6/Ku70; the interaction is dependent on nucleic acids (PubMed:16924674, PubMed:24598253). Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4 (PubMed:16924674).
    Miscellaneous:
    • [Isoform 1]: More abundant isoform.

    Three dimensional structures from OCA and Proteopedia for PARP3 Gene

    Alternative splice isoforms for PARP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP3 Gene

Post-translational modifications for PARP3 Gene

No data available for DME Specific Peptides for PARP3 Gene

Domains & Families for PARP3 Gene

Gene Families for PARP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PARP3 Gene

InterPro:
Blocks:
  • Poly(ADP-ribose) polymerase, regulatory domain
  • WGR

Suggested Antigen Peptide Sequences for PARP3 Gene

GenScript: Design optimal peptide antigens:
  • Poly[ADP-ribose] synthase 3 (PARP3_HUMAN)
genes like me logo Genes that share domains with PARP3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP3 Gene

Function for PARP3 Gene

Molecular function for PARP3 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=130 uM for NAD(+) {ECO:0000269|PubMed:20064938};

Enzyme Numbers (IUBMB) for PARP3 Gene

Phenotypes From GWAS Catalog for PARP3 Gene

Gene Ontology (GO) - Molecular Function for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IDA 21211721
GO:0005515 protein binding IPI 20064938
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP3: view
genes like me logo Genes that share phenotypes with PARP3: view

Animal Models for PARP3 Gene

MGI Knock Outs for PARP3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP3 Gene

Localization for PARP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP3 Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334). Preferentially localized to the daughter centriole (PubMed:10329013). {ECO:0000269 PubMed:10329013, ECO:0000269 PubMed:16924674, ECO:0000269 PubMed:21270334}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PARP3: view

Pathways & Interactions for PARP3 Gene

PathCards logo

SuperPathways for PARP3 Gene

genes like me logo Genes that share pathways with PARP3: view

Pathways by source for PARP3 Gene

1 Sino Biological pathway for PARP3 Gene
2 KEGG pathways for PARP3 Gene
1 GeneGo (Thomson Reuters) pathway for PARP3 Gene
  • NAD metabolism
4 Qiagen pathways for PARP3 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IMP 21270334
GO:0006281 DNA repair IEA,TAS 7260241
GO:0006302 double-strand break repair IEA,IMP 21211721
GO:0006471 protein ADP-ribosylation IEA,IDA 21270334
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with PARP3: view

No data available for SIGNOR curated interactions for PARP3 Gene

Drugs & Compounds for PARP3 Gene

(11) Drugs for PARP3 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olaparib Approved Pharma Target, inhibitor PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 321
Rucaparib Approved, Investigational Pharma Target, antagonist PARP inhibitor, PARP Inhibitors, Other 64
Nicotinamide Approved, Investigational Pharma 474,474
NADH Approved Nutra 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0

(2) Additional Compounds for PARP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP3 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2

(2) ApexBio Compounds for PARP3 Gene

Compound Action Cas Number
NU 1025 PARP inhibitor,potent and novel 90417-38-2
PJ34 hydrochloride PARP inhibitor,potent and cell-permeable 344458-15-7
genes like me logo Genes that share compounds with PARP3: view

Drug products for research

Transcripts for PARP3 Gene

mRNA/cDNA for PARP3 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP3

Alternative Splicing Database (ASD) splice patterns (SP) for PARP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for PARP3 Gene

GeneLoc Exon Structure for
PARP3

Expression for PARP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP3 Gene

Protein differential expression in normal tissues from HIPED for PARP3 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARP3 Gene



Protein tissue co-expression partners for PARP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP3

SOURCE GeneReport for Unigene cluster for PARP3 Gene:

Hs.271742

mRNA Expression by UniProt/SwissProt for PARP3 Gene:

Q9Y6F1-PARP3_HUMAN
Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

Evidence on tissue expression from TISSUES for PARP3 Gene

  • Nervous system(4.4)
  • Kidney(4.4)
genes like me logo Genes that share expression patterns with PARP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP3 Gene

Orthologs for PARP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP3 29 30
  • 98.95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP3 29 30
  • 86.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP3 29 30
  • 82.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp3 29 16 30
  • 82.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp3 29
  • 81.88 (n)
Oppossum
(Monodelphis domestica)
Mammalia PARP3 30
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PARP3 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PARP3 29 30
  • 68.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP3 30
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp3 29
  • 64.11 (n)
Str.15161 29
Zebrafish
(Danio rerio)
Actinopterygii parp3 29 30
  • 59.82 (n)
OneToOne
zgc66157 29
Worm
(Caenorhabditis elegans)
Secernentea Y75B7B.2 30
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 9 (a)
OneToOne
Species where no ortholog for PARP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PARP3 Gene

ENSEMBL:
Gene Tree for PARP3 (if available)
TreeFam:
Gene Tree for PARP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP3: view image
Alliance of Genome Resources:
Additional Orthologs for PARP3

Paralogs for PARP3 Gene

Paralogs for PARP3 Gene

(1) SIMAP similar genes for PARP3 Gene using alignment to 3 proteins:

  • PARP3_HUMAN
  • C9J9C7_HUMAN
  • F8WAY7_HUMAN
genes like me logo Genes that share paralogs with PARP3: view

Variants for PARP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs112817696 Benign: not provided 51,943,496(+) C/T
NM_001003931.3(PARP3):c.162C>T (p.Arg54=)
SYNONYMOUS
rs61729070 Benign: not provided 51,943,369(+) C/T
NM_001003931.3(PARP3):c.35C>T (p.Pro12Leu)
MISSENSE
rs76343500 Benign: not provided 51,946,220(+) G/A
NM_001003931.3(PARP3):c.1174G>A (p.Gly392Ser)
MISSENSE
rs77898224 Benign: not provided 51,943,476(+) G/T
NM_001003931.3(PARP3):c.142G>T (p.Ala48Ser)
MISSENSE
rs9819090 Benign: not provided 51,944,587(+) G/A
NM_001003931.3(PARP3):c.522+9G>A
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP3 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv590280 CNV loss 21841781
nsv954857 CNV deletion 24416366

Variation tolerance for PARP3 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP3
Leiden Open Variation Database (LOVD)
PARP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP3 Gene

Disorders for PARP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP3 Gene - From: COP

Disorder Aliases PubMed IDs
osebold-remondini syndrome
  • brachymesophalangy with mesomelic short limbs and carpal and tarsal osseous abnormalities
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
- elite association - COSMIC cancer census association via MalaCards
Search PARP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PARP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP3 Gene

Publications for PARP3 Gene

  1. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. (PMID: 10329013) Johansson M (Genomics 1999) 2 3 4 22
  2. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. (PMID: 12640039) Augustin A … De Murcia G (Journal of cell science 2003) 3 4 22
  3. Dna is a New Target of Parp3. (PMID: 29520010) Belousova EA … Lavrik OI (Scientific reports 2018) 3 4
  4. Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. (PMID: 29361132) Zarkovic G … Ishchenko AA (Nucleic acids research 2018) 3 4
  5. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4

Products for PARP3 Gene

Sources for PARP3 Gene