Aliases for PARP2 Gene
- Poly(ADP-Ribose) Polymerase 2 2 3 5
- ARTD2 2 3 4
- ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 2 3 4
- Poly (ADP-Ribose) Polymerase Family, Member 2 2 3
- Protein Poly-ADP-Ribosyltransferase PARP2 3 4
- DNA ADP-Ribosyltransferase PARP2 3 4
- NAD(+) ADP-Ribosyltransferase 2 3 4
- Poly [ADP-Ribose] Polymerase 2 3 4
- Poly[ADP-Ribose] Synthase 2 3 4
- EC 188.8.131.52 4 50
External Ids for PARP2 Gene
Previous HGNC Symbols for PARP2 Gene
Previous GeneCards Identifiers for PARP2 Gene
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP2 Gene
PARP2 (Poly(ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Osebold-Remondini Syndrome and Cockayne Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP1.
UniProtKB/Swiss-Prot Summary for PARP2 Gene
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.