This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transfe... See more...

Aliases for PARP2 Gene

Aliases for PARP2 Gene

  • Poly(ADP-Ribose) Polymerase 2 2 3 5
  • ARTD2 2 3 4
  • ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 2 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 2 2 3
  • Protein Poly-ADP-Ribosyltransferase PARP2 3 4
  • DNA ADP-Ribosyltransferase PARP2 3 4
  • NAD(+) ADP-Ribosyltransferase 2 3 4
  • Poly [ADP-Ribose] Polymerase 2 3 4
  • Poly[ADP-Ribose] Synthase 2 3 4
  • EC 2.4.2.30 4 51
  • PADPRT-2 3 4
  • ADPRTL2 3 4
  • ADPRT-2 3 4
  • HPARP-2 3 4
  • ADPRT2 3 4
  • PARP-2 3 4
  • Poly (ADP-Ribosyl) Transferase-Like 2 3
  • Poly[ADP-Ribose] Synthetase 2 3
  • EC 2.4.2.- 4
  • ADPRTL3 3
  • PARP2 5

External Ids for PARP2 Gene

Previous HGNC Symbols for PARP2 Gene

  • ADPRTL2

Previous GeneCards Identifiers for PARP2 Gene

  • GC14P019881
  • GC14P020811
  • GC14P000933

Summaries for PARP2 Gene

Entrez Gene Summary for PARP2 Gene

  • This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARP2 Gene

PARP2 (Poly(ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Nucleotide excision repair. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP1.

UniProtKB/Swiss-Prot Summary for PARP2 Gene

  • Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).

Tocris Summary for PARP2 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP2 Gene

Genomics for PARP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP2

Top Transcription factor binding sites by QIAGEN in the PARP2 gene promoter:
  • Evi-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • N-Myc
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5A

Genomic Locations for PARP2 Gene

Genomic Locations for PARP2 Gene
chr14:20,343,041-20,357,905
(GRCh38/hg38)
Size:
14,865 bases
Orientation:
Plus strand
chr14:20,811,741-20,826,064
(GRCh37/hg19)
Size:
14,324 bases
Orientation:
Plus strand

Genomic View for PARP2 Gene

Genes around PARP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP2 Gene

Proteins for PARP2 Gene

  • Protein details for PARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGN5-PARP2_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 2
    Protein Accession:
    Q9UGN5
    Secondary Accessions:
    • Q8TEU4
    • Q9NUV2
    • Q9UMR4
    • Q9Y6C8

    Protein attributes for PARP2 Gene

    Size:
    583 amino acids
    Molecular mass:
    66206 Da
    Quaternary structure:
    • Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3 (By similarity). Homo- and heterodimer with PARP1 (PubMed:20092359). Interacts weakly (via the PARP catalytic domain) with HPF1 (PubMed:27067600, PubMed:28190768).
    SequenceCaution:
    • Sequence=AAD29857.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL77437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB41505.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP2 Gene

    Alternative splice isoforms for PARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP2 Gene

Selected DME Specific Peptides for PARP2 Gene

Q9UGN5:
  • GKGIYFA
  • LLWHGSR
  • YNEYIVY
  • LLSEVALG

Post-translational modifications for PARP2 Gene

Domains & Families for PARP2 Gene

Gene Families for PARP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PARP2 Gene

InterPro:
Blocks:
  • Poly(ADP-ribose) polymerase, regulatory domain
  • WGR
ProtoNet:

Suggested Antigen Peptide Sequences for PARP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58629, highly similar to Poly (ADP-ribose) polymerase 2 (EC 2.4.2.30) (B4DV82_HUMAN)
  • Poly[ADP-ribose] synthase 2 (PARP2_HUMAN)
genes like me logo Genes that share domains with PARP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP2 Gene

Function for PARP2 Gene

Molecular function for PARP2 Gene

UniProtKB/Swiss-Prot Function:
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.; EC=2.4.2.30; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]; Xref=Rhea:RHEA:58232, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:15091, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29999, ChEBI:CHEBI:57540, ChEBI:CHEBI:142556; Evidence={ECO:0000305|PubMed:28190768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:25043379};.

Enzyme Numbers (IUBMB) for PARP2 Gene

Phenotypes From GWAS Catalog for PARP2 Gene

Gene Ontology (GO) - Molecular Function for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 21812934
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP2: view
genes like me logo Genes that share phenotypes with PARP2: view

Animal Models for PARP2 Gene

MGI Knock Outs for PARP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PARP2

CRISPR Products

miRNA for PARP2 Gene

miRTarBase miRNAs that target PARP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP2 Gene

Localization for PARP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA 15615785
GO:0005730 nucleolus IDA 15615785
genes like me logo Genes that share ontologies with PARP2: view

Pathways & Interactions for PARP2 Gene

genes like me logo Genes that share pathways with PARP2: view

Pathways by source for PARP2 Gene

2 KEGG pathways for PARP2 Gene
1 GeneGo (Thomson Reuters) pathway for PARP2 Gene
  • NAD metabolism

Gene Ontology (GO) - Biological Process for PARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS 7260241
GO:0006284 base-excision repair IEA --
GO:0006302 double-strand break repair IBA 21873635
GO:0006471 protein ADP-ribosylation IEA,TAS 7260241
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with PARP2: view

No data available for SIGNOR curated interactions for PARP2 Gene

Drugs & Compounds for PARP2 Gene

(36) Drugs for PARP2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma Target, antagonist, inhibitor, Biomarker, other PARP inhibitor, PARP Inhibitors, Other 57
Niraparib Approved, Investigational Pharma Target, antagonist, inhibitor, Biomarker PARP inhibitor, PARP Inhibitors 93
Olaparib Approved Pharma Target, inhibitor, Biomarker, other PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 277
Talazoparib Approved, Investigational Pharma Target, inhibitor 65
Nicotinamide Approved, Investigational Pharma 427,427

(5) Additional Compounds for PARP2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP2 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2

(22) ApexBio Compounds for PARP2 Gene

Compound Action Cas Number
4-HQN PARP inhibitor 491-36-1
A-966492 PARP-1/-2 inhibitor, highly potent 934162-61-5
ABT-888 (Veliparib) Potent PARP inhibitor 912444-00-9
AZD2461 Novel PARP inhibitor 1174043-16-3
BMN 673 Potent PARP inhibitor 1207456-01-6
BYK 49187 Potent PARP-1/PARP-2 inhibitor 163120-31-8
DR 2313 PARP inhibitor 284028-90-6
INO-1001 Potent PARP inhibitor 3544-24-9
JW 55 PARP domain inhibitor 664993-53-7
ME0328 PARP inhibitor,potent and selective 1445251-22-8
MK-4827 PARP-1/-2 inhibitor,potent and selective 1038915-60-4
MK-4827 hydrochloride PARP1/PARP2 inhibitor 1038915-64-8
MK-4827 Racemate 1038915-75-1
MK-4827 tosylate PARP1/PARP2 inhibitor 1038915-73-9
NU 1025 PARP inhibitor,potent and novel 90417-38-2
Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor 763113-22-0
PJ34 hydrochloride PARP inhibitor,potent and cell-permeable 344458-15-7
Rucaparib (AG-014699,PF-01367338) Potent PARP inhibitor 459868-92-9
Rucaparib (free base) Potent PARP inhibitor 283173-50-2
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
Veliparib dihydrochloride PARP-1/PARP-2 inhibitor 912445-05-7
WIKI4 Inhibitor of Wnt/ß-Catenin signaling and tankyrase 838818-26-1
genes like me logo Genes that share compounds with PARP2: view

Drug Products

Transcripts for PARP2 Gene

mRNA/cDNA for PARP2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP2

Alternative Splicing Database (ASD) splice patterns (SP) for PARP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PARP2 Gene

GeneLoc Exon Structure for
PARP2

Expression for PARP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP2 Gene

Protein differential expression in normal tissues from HIPED for PARP2 Gene

This gene is overexpressed in Lung (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP2 Gene



Protein tissue co-expression partners for PARP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP2

SOURCE GeneReport for Unigene cluster for PARP2 Gene:

Hs.409412

mRNA Expression by UniProt/SwissProt for PARP2 Gene:

Q9UGN5-PARP2_HUMAN
Tissue specificity: Widely expressed, mainly in actively dividing tissues (PubMed:10364231). The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus (PubMed:10364231).

Evidence on tissue expression from TISSUES for PARP2 Gene

  • Nervous system(4.8)
  • Skin(2.5)
  • Intestine(2.5)
  • Liver(2.4)
  • Muscle(2.4)
  • Kidney(2.3)
  • Bone marrow(2.2)
  • Lung(2.2)
  • Blood(2.2)
  • Heart(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PARP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP2 Gene

Orthologs for PARP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PARP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP2 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP2 30 31
  • 89.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP2 30 31
  • 87.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp2 30 17 31
  • 86.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp2 30
  • 86.12 (n)
Oppossum
(Monodelphis domestica)
Mammalia PARP2 31
  • 56 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP2 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp2 30
  • 65.41 (n)
Zebrafish
(Danio rerio)
Actinopterygii parp2 30 31
  • 62.55 (n)
OneToOne
-- 30
Worm
(Caenorhabditis elegans)
Secernentea pme-2 31
  • 26 (a)
OneToMany
pme-5 31
  • 5 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PP 30
  • 51.99 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0351100 30
  • 52.53 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.8751 30
Wheat
(Triticum aestivum)
Liliopsida Ta.3786 30
Corn
(Zea mays)
Liliopsida Zm.164 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
CSA.5817 31
  • 27 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14032 30
Species where no ortholog for PARP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PARP2 Gene

ENSEMBL:
Gene Tree for PARP2 (if available)
TreeFam:
Gene Tree for PARP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP2: view image

Paralogs for PARP2 Gene

Paralogs for PARP2 Gene

(2) SIMAP similar genes for PARP2 Gene using alignment to 4 proteins:

  • PARP2_HUMAN
  • E9PJ27_HUMAN
  • G3V167_HUMAN
  • H0YH02_HUMAN

Pseudogenes.org Pseudogenes for PARP2 Gene

genes like me logo Genes that share paralogs with PARP2: view

Variants for PARP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
727595 Likely Benign: not provided 20,351,102(+) C/T SYNONYMOUS_VARIANT
734062 Benign: not provided 20,357,716(+) T/C SYNONYMOUS_VARIANT
779651 Benign: not provided 20,351,068(+) G/A MISSENSE_VARIANT
779652 Benign: not provided 20,355,963(+) T/C SYNONYMOUS_VARIANT
rs2275010 - p.Ile331Thr

Additional dbSNP identifiers (rs#s) for PARP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PARP2 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
nsv1042025 CNV loss 25217958

Variation tolerance for PARP2 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP2 Gene

Human Gene Mutation Database (HGMD)
PARP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP2 Gene

Disorders for PARP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PARP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osebold-remondini syndrome
  • brachymesophalangy with mesomelic short limbs and carpal and tarsal osseous abnormalities
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards
Search PARP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PARP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP2 Gene

Publications for PARP2 Gene

  1. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. (PMID: 10329013) Johansson M (Genomics 1999) 2 3 4 23
  2. LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest. (PMID: 19806447) Sakugawa N … Sengoku K (Journal of assisted reproduction and genetics 2009) 3 23 41
  3. Toward specific functions of poly(ADP-ribose) polymerase-2. (PMID: 18353725) Yélamos J … Dantzer F (Trends in molecular medicine 2008) 2 3 23
  4. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. (PMID: 10364231) Amé JC … de Murcia G (The Journal of biological chemistry 1999) 3 4 23
  5. Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4

Products for PARP2 Gene

  • Signalway ELISA kits for PARP2

Sources for PARP2 Gene