Aliases for PARP16 Gene

Aliases for PARP16 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 16 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 15 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP16 3 4
  • Poly [ADP-Ribose] Polymerase 16 3 4
  • C15orf30 3 4
  • PARP-16 3 4
  • ARTD15 3 4
  • Mono [ADP-Ribose] Polymerase PARP16 3
  • Chromosome 15 Open Reading Frame 30 2
  • EC 2.4.2.- 4
  • PART15 3

External Ids for PARP16 Gene

Previous HGNC Symbols for PARP16 Gene

  • C15orf30

Previous GeneCards Identifiers for PARP16 Gene

  • GC15M063337
  • GC15M065550
  • GC15M042375

Summaries for PARP16 Gene

GeneCards Summary for PARP16 Gene

PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16) is a Protein Coding gene. Diseases associated with PARP16 include Osebold-Remondini Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include kinase binding and protein serine/threonine kinase activator activity. An important paralog of this gene is PARP6.

UniProtKB/Swiss-Prot Summary for PARP16 Gene

  • Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Tocris Summary for PARP16 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP16 Gene

Genomics for PARP16 Gene

GeneHancer (GH) Regulatory Elements for PARP16 Gene

Promoters and enhancers for PARP16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP16

Top Transcription factor binding sites by QIAGEN in the PARP16 gene promoter:
  • ATF6
  • c-Ets-1
  • C/EBPalpha
  • Egr-3
  • LCR-F1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for PARP16 Gene

Genomic Locations for PARP16 Gene
chr15:65,234,460-65,300,618
(GRCh38/hg38)
Size:
66,159 bases
Orientation:
Minus strand
chr15:65,526,798-65,592,956
(GRCh37/hg19)
Size:
66,159 bases
Orientation:
Minus strand

Genomic View for PARP16 Gene

Genes around PARP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP16 Gene

Proteins for PARP16 Gene

  • Protein details for PARP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y8-PAR16_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP16
    Protein Accession:
    Q8N5Y8
    Secondary Accessions:
    • A0A024R5Y7
    • Q6PK64
    • Q9NX03

    Protein attributes for PARP16 Gene

    Size:
    322 amino acids
    Molecular mass:
    36383 Da
    Quaternary structure:
    • Interacts with KPNB1.

    Three dimensional structures from OCA and Proteopedia for PARP16 Gene

    Alternative splice isoforms for PARP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP16 Gene

Post-translational modifications for PARP16 Gene

No data available for DME Specific Peptides for PARP16 Gene

Domains & Families for PARP16 Gene

Gene Families for PARP16 Gene

Protein Domains for PARP16 Gene

Suggested Antigen Peptide Sequences for PARP16 Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 16 (PAR16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5Y8

UniProtKB/Swiss-Prot:

PAR16_HUMAN :
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
Domain:
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
genes like me logo Genes that share domains with PARP16: view

Function for PARP16 Gene

Molecular function for PARP16 Gene

UniProtKB/Swiss-Prot Function:
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54425; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58221; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58225; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=290 uM for NAD (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565}; Vmax=0.7 pmol/h/ug enzyme (at 37 degrees Celsius) {ECO:0000269 PubMed:22701565};

Enzyme Numbers (IUBMB) for PARP16 Gene

Phenotypes From GWAS Catalog for PARP16 Gene

Gene Ontology (GO) - Molecular Function for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IMP 22701565
GO:0005515 protein binding IPI 22701565
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0019900 kinase binding IPI,IBA 23103912
genes like me logo Genes that share ontologies with PARP16: view
genes like me logo Genes that share phenotypes with PARP16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP16

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP16 Gene

Localization for PARP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP16 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS