Aliases for PARP16 Gene
External Ids for PARP16 Gene
Previous HGNC Symbols for PARP16 Gene
Previous GeneCards Identifiers for PARP16 Gene
GeneCards Summary for PARP16 Gene
PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16) is a Protein Coding gene. Diseases associated with PARP16 include Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include kinase binding and protein serine/threonine kinase activator activity. An important paralog of this gene is PARP6.
UniProtKB/Swiss-Prot Summary for PARP16 Gene
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.