Aliases for PARP16 Gene

Aliases for PARP16 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 16 2 3 5
  • ARTD15 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 15 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP16 3 4
  • Poly [ADP-Ribose] Polymerase 16 3 4
  • C15orf30 3 4
  • PARP-16 3 4
  • PART15 2 3
  • Chromosome 15 Open Reading Frame 30 2
  • Mono [ADP-Ribose] Polymerase PARP16 3
  • EC 2.4.2.- 4
  • FLJ20509 2
  • FLJ25281 2
  • PARP16 5

External Ids for PARP16 Gene

Previous HGNC Symbols for PARP16 Gene

  • C15orf30

Previous GeneCards Identifiers for PARP16 Gene

  • GC15M063337
  • GC15M065550
  • GC15M042375
  • GC15M065234
  • GC15M065355

Summaries for PARP16 Gene

GeneCards Summary for PARP16 Gene

PARP16 (Poly(ADP-Ribose) Polymerase Family Member 16) is a Protein Coding gene. Diseases associated with PARP16 include Osebold-Remondini Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include kinase binding and protein serine/threonine kinase activator activity. An important paralog of this gene is PARP6.

UniProtKB/Swiss-Prot Summary for PARP16 Gene

  • Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Tocris Summary for PARP16 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP16 Gene

Genomics for PARP16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP16

Top Transcription factor binding sites by QIAGEN in the PARP16 gene promoter:
  • ATF6
  • c-Ets-1
  • C/EBPalpha
  • Egr-3
  • LCR-F1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for PARP16 Gene

Latest Assembly
chr15:65,231,691-65,300,618
(GRCh38/hg38)
Size:
68,928 bases
Orientation:
Minus strand

Previous Assembly
chr15:65,550,437-65,579,221
(GRCh37/hg19 by Entrez Gene)
Size:
28,785 bases
Orientation:
Minus strand

chr15:65,526,798-65,592,956
(GRCh37/hg19 by Ensembl)
Size:
66,159 bases
Orientation:
Minus strand

Genomic View for PARP16 Gene

Genes around PARP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP16 Gene

Proteins for PARP16 Gene

  • Protein details for PARP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y8-PAR16_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP16
    Protein Accession:
    Q8N5Y8
    Secondary Accessions:
    • A0A024R5Y7
    • Q6PK64
    • Q9NX03

    Protein attributes for PARP16 Gene

    Size:
    322 amino acids
    Molecular mass:
    36383 Da
    Quaternary structure:
    • Interacts with KPNB1.

    Three dimensional structures from OCA and Proteopedia for PARP16 Gene

    Alternative splice isoforms for PARP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP16 Gene

Post-translational modifications for PARP16 Gene

No data available for DME Specific Peptides for PARP16 Gene

Domains & Families for PARP16 Gene

Gene Families for PARP16 Gene

Protein Domains for PARP16 Gene

Suggested Antigen Peptide Sequences for PARP16 Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 16 (PAR16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5Y8

UniProtKB/Swiss-Prot:

PAR16_HUMAN :
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
Domain:
  • The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
genes like me logo Genes that share domains with PARP16: view

Function for PARP16 Gene

Molecular function for PARP16 Gene

UniProtKB/Swiss-Prot Function:
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=290 uM for NAD (at 37 degrees Celsius) {ECO:0000269|PubMed:22701565}; Vmax=0.7 pmol/h/ug enzyme (at 37 degrees Celsius) {ECO:0000269|PubMed:22701565};

Enzyme Numbers (IUBMB) for PARP16 Gene

Phenotypes From GWAS Catalog for PARP16 Gene

Gene Ontology (GO) - Molecular Function for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IBA,IMP 22701565
GO:0005515 protein binding IPI 22701565
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0019900 kinase binding IBA,IPI 23103912
genes like me logo Genes that share ontologies with PARP16: view
genes like me logo Genes that share phenotypes with PARP16: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP16

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP16 Gene

Localization for PARP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP16 Gene

Endoplasmic reticulum membrane. Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP16 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
GO:0005635 nuclear envelope IBA,IDA 22701565
GO:0005783 endoplasmic reticulum IMP 23103912
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PARP16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PARP16 Gene

Pathways & Interactions for PARP16 Gene

genes like me logo Genes that share pathways with PARP16: view

Pathways by source for PARP16 Gene

4 Qiagen pathways for PARP16 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IMP 22701565
GO:0006986 response to unfolded protein IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IMP 23103912
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
GO:0036498 IRE1-mediated unfolded protein response IMP 23103912
genes like me logo Genes that share ontologies with PARP16: view

No data available for SIGNOR curated interactions for PARP16 Gene

Drugs & Compounds for PARP16 Gene

(4) Drugs for PARP16 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP16 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP16: view

Transcripts for PARP16 Gene

mRNA/cDNA for PARP16 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP16

Alternative Splicing Database (ASD) splice patterns (SP) for PARP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7: - - - - - - -

Relevant External Links for PARP16 Gene

GeneLoc Exon Structure for
PARP16

Expression for PARP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

Protein differential expression in normal tissues from HIPED for PARP16 Gene

This gene is overexpressed in Fetal ovary (16.0), Fetal testis (12.0), Ovary (9.5), Blymphocyte (8.6), Prostate (6.9), and CD4 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP16 Gene



Protein tissue co-expression partners for PARP16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP16

SOURCE GeneReport for Unigene cluster for PARP16 Gene:

Hs.30634

Evidence on tissue expression from TISSUES for PARP16 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PARP16: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP16 Gene

Orthologs for PARP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for PARP16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP16 29 30
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP16 29 30
  • 90.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP16 29 30
  • 90.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp16 29 16 30
  • 87.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp16 29
  • 85.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia PARP16 30
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PARP16 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PARP16 30
  • 51 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP16 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp16 29
  • 64.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii parp16 29 30
  • 63.54 (n)
OneToOne
Dr.12643 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007419 29
  • 47.77 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.87 30
  • 40 (a)
OneToOne
Species where no ortholog for PARP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP16 Gene

ENSEMBL:
Gene Tree for PARP16 (if available)
TreeFam:
Gene Tree for PARP16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP16: view image
Alliance of Genome Resources:
Additional Orthologs for PARP16

Paralogs for PARP16 Gene

Paralogs for PARP16 Gene

genes like me logo Genes that share paralogs with PARP16: view

Variants for PARP16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP16 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs34957967 Benign: not provided 65,259,416(-) C/T
NM_001316943.2(PARP16):c.960G>A (p.Ala320=)
SYNONYMOUS
rs17852901 -- p.Ser280Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP16 Gene

Variant ID Type Subtype PubMed ID
nsv457182 CNV loss 19166990
nsv476908 CNV novel sequence insertion 20440878
nsv569705 CNV loss 21841781

Variation tolerance for PARP16 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP16
Leiden Open Variation Database (LOVD)
PARP16

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP16 Gene

Disorders for PARP16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP16 Gene - From: COP

Disorder Aliases PubMed IDs
osebold-remondini syndrome
  • brachymesophalangy with mesomelic short limbs and carpal and tarsal osseous abnormalities
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PARP16

genes like me logo Genes that share disorders with PARP16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP16 Gene

Publications for PARP16 Gene

  1. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  2. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. (PMID: 23103912) Jwa M … Chang P (Nature cell biology 2012) 3 4
  3. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. (PMID: 22701565) Di Paola S … Di Girolamo M (PloS one 2012) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for PARP16 Gene

Sources for PARP16 Gene