Aliases for PARP15 Gene
External Ids for PARP15 Gene
Previous GeneCards Identifiers for PARP15 Gene
PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
GeneCards Summary for PARP15 Gene
PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) is a Protein Coding gene. Diseases associated with PARP15 include Bejel and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Granzyme Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.
UniProtKB/Swiss-Prot Summary for PARP15 Gene
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.