This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016] See more...

Aliases for PARP14 Gene

Aliases for PARP14 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 14 2 3 5
  • ARTD8 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 8 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP14 3 4
  • B Aggressive Lymphoma Protein 2 3 4
  • Poly [ADP-Ribose] Polymerase 14 3 4
  • KIAA1268 2 4
  • PARP-14 3 4
  • PART8 2 3
  • BAL2 3 4
  • B-Aggressive Lymphoma 2 3
  • Collaborator Of STAT6 3
  • EC 2.4.2.30 50
  • EC 2.4.2.- 4
  • PARP14 5

External Ids for PARP14 Gene

Previous GeneCards Identifiers for PARP14 Gene

  • GC03P123897
  • GC03P122399
  • GC03P119772

Summaries for PARP14 Gene

Entrez Gene Summary for PARP14 Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

GeneCards Summary for PARP14 Gene

PARP14 (Poly(ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot Summary for PARP14 Gene

  • ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).

Tocris Summary for PARP14 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP14 Gene

Genomics for PARP14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J122678 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 274.3 +0.6 572 5.9 BCLAF1 ZNF207 ZNF654 ZNF600 ZNF580 ZMYM3 POLR2A NFIC ZBTB10 YY1 PARP14 DTX3L PARP9 HSPBAP1 SLC49A4 LINC02035 CSTA KPNA1 HSALNG0028505
GH03J122718 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.3 +37.7 37699 0.1 PARP14 HSPBAP1 SLC49A4 piR-49423-167 HSALNG0028505
GH03J122792 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.4 +114.3 114275 5.6 SP1 ZNF207 MYC ZNF600 SSRP1 JUND ZNF592 ATF2 POLR2A BRCA1 SLC49A4 HSPBAP1 IQCB1 SEC22A ENSG00000273454 WDR5B-DT PARP14 LINC02035 PARP9 DTX3L
GH03J122766 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 31.1 +87.5 87495 3.6 SPI1 POLR2A HSALNG0028511 SLC49A4 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1 lnc-SEMA5B-2
GH03J122773 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +93.4 93415 1.8 TRIM22 SMARCA5 CTCF SPI1 ZNF24 NR2F1 PKNOX1 IKZF1 HLF TARDBP PARP14 HSPBAP1 DTX3L PARP9 SLC49A4 CSTA KPNA1 lnc-SEMA5B-2 piR-49732-420
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP14

Top Transcription factor binding sites by QIAGEN in the PARP14 gene promoter:
  • c-Ets-1
  • c-Myb
  • CUTL1
  • GATA-1
  • GATA-2
  • IRF-1
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for PARP14 Gene

Latest Assembly
chr3:122,680,726-122,730,840
(GRCh38/hg38)
Size:
50,115 bases
Orientation:
Plus strand

Previous Assembly
chr3:122,399,686-122,449,687
(GRCh37/hg19 by Entrez Gene)
Size:
50,002 bases
Orientation:
Plus strand

chr3:122,399,465-122,449,687
(GRCh37/hg19 by Ensembl)
Size:
50,223 bases
Orientation:
Plus strand

Genomic View for PARP14 Gene

Genes around PARP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP14 Gene

Proteins for PARP14 Gene

  • Protein details for PARP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N5-PAR14_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP14
    Protein Accession:
    Q460N5
    Secondary Accessions:
    • B4E2H0
    • Q460N4
    • Q8J027
    • Q9H9X9
    • Q9NV60
    • Q9ULF2

    Protein attributes for PARP14 Gene

    Size:
    1801 amino acids
    Molecular mass:
    202800 Da
    Quaternary structure:
    • Interacts with STAT6 (By similarity). Interacts with PARP10 (PubMed:23473667). Interacts with PARP9 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP-riboslylation (PubMed:27796300).
    SequenceCaution:
    • Sequence=AAY64449.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAY64450.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14089.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=DB237115; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP14 Gene

    Alternative splice isoforms for PARP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP14 Gene

Selected DME Specific Peptides for PARP14 Gene

Q460N5:
  • GKGTYFA
  • KIERIQN
  • PAIGTGN

Post-translational modifications for PARP14 Gene

  • Auto-ADP-ribosylated.
  • Ubiquitination at Lys1048, Lys381, Lys1203, Lys1282, Lys599, Lys1400, Lys721, Lys1516, Lys828, Lys854, Lys1589, Lys1670, Lys1005, and Lys1020
  • Modification sites at PhosphoSitePlus

Other Protein References for PARP14 Gene

Domains & Families for PARP14 Gene

Gene Families for PARP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PARP14 Gene

Suggested Antigen Peptide Sequences for PARP14 Gene

GenScript: Design optimal peptide antigens:
  • Poly (ADP-ribose) polymerase family, member 14, isoform CRA_a (D3DN94_HUMAN)
  • B aggressive lymphoma protein 2 (PAR14_HUMAN)
  • PARP14 protein (Q8N546_HUMAN)
genes like me logo Genes that share domains with PARP14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP14 Gene

Function for PARP14 Gene

Molecular function for PARP14 Gene

UniProtKB/Swiss-Prot Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:27796300};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG in macrophages. Down-regulated by IL4 in macrophages.

Enzyme Numbers (IUBMB) for PARP14 Gene

Phenotypes From GWAS Catalog for PARP14 Gene

Gene Ontology (GO) - Molecular Function for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0003950 NAD+ ADP-ribosyltransferase activity IBA,IDA 27796300
GO:0005515 protein binding IPI 23473667
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP14: view
genes like me logo Genes that share phenotypes with PARP14: view

miRNA for PARP14 Gene

miRTarBase miRNAs that target PARP14

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP14

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP14 Gene

Localization for PARP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP14 Gene

Nucleus. Cytoplasm. Note=In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm (PubMed:27796300). {ECO:0000250 UniProtKB:Q2EMV9, ECO:0000269 PubMed:27796300}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP14 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 27796300
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PARP14: view

Pathways & Interactions for PARP14 Gene

genes like me logo Genes that share pathways with PARP14: view

Pathways by source for PARP14 Gene

4 Qiagen pathways for PARP14 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006471 protein ADP-ribosylation IDA 27796300
GO:0010629 negative regulation of gene expression IBA,IMP 27796300
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP 27796300
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IMP 27796300
genes like me logo Genes that share ontologies with PARP14: view

No data available for SIGNOR curated interactions for PARP14 Gene

Drugs & Compounds for PARP14 Gene

(4) Drugs for PARP14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP14 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP14: view

Transcripts for PARP14 Gene

mRNA/cDNA for PARP14 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP14

Alternative Splicing Database (ASD) splice patterns (SP) for PARP14 Gene

No ASD Table

Relevant External Links for PARP14 Gene

GeneLoc Exon Structure for
PARP14

Expression for PARP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP14 Gene

Protein differential expression in normal tissues from HIPED for PARP14 Gene

This gene is overexpressed in Lymph node (17.5), Lavage (12.8), Peripheral blood mononuclear cells (9.5), and Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP14 Gene



Protein tissue co-expression partners for PARP14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP14

SOURCE GeneReport for Unigene cluster for PARP14 Gene:

Hs.518203

mRNA Expression by UniProt/SwissProt for PARP14 Gene:

Q460N5-PAR14_HUMAN
Tissue specificity: Expressed in macrophages.

Evidence on tissue expression from TISSUES for PARP14 Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Spleen(2.7)
  • Lung(2.6)
  • Kidney(2.3)
  • Intestine(2.2)
  • Heart(2.2)
  • Muscle(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with PARP14: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP14 Gene

Orthologs for PARP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP14 29 30
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP14 29 30
  • 81.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP14 29 30
  • 78.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp14 29
  • 73.78 (n)
Mouse
(Mus musculus)
Mammalia Parp14 29 16 30
  • 73.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 49 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves PARP14 29
  • 56.65 (n)
-- 30
  • 43 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 49 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732564 29
  • 51.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19831 29
Zebrafish
(Danio rerio)
Actinopterygii parp14 29
  • 49.63 (n)
CABZ01031892.1 30
  • 34 (a)
ManyToMany
si:ch211-219a4.3 30
  • 33 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToMany
Species where no ortholog for PARP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP14 Gene

ENSEMBL:
Gene Tree for PARP14 (if available)
TreeFam:
Gene Tree for PARP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP14: view image
Alliance of Genome Resources:
Additional Orthologs for PARP14

Paralogs for PARP14 Gene

Paralogs for PARP14 Gene

(1) SIMAP similar genes for PARP14 Gene using alignment to 5 proteins:

  • PAR14_HUMAN
  • D3DN94_HUMAN
  • H7C4Y3_HUMAN
  • H7C5R8_HUMAN
  • Q8N546_HUMAN

Pseudogenes.org Pseudogenes for PARP14 Gene

genes like me logo Genes that share paralogs with PARP14: view

Variants for PARP14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP14 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs16833413 Benign: not provided 122,700,016(+) G/A
NM_017554.3(PARP14):c.1462G>A (p.Asp488Asn)
MISSENSE
rs16833421 Benign: not provided 122,701,146(+) C/T
NM_017554.3(PARP14):c.2592C>T (p.Ala864=)
SYNONYMOUS
rs61732767 Benign: not provided 122,718,689(+) C/T
NM_017554.3(PARP14):c.4538C>T (p.Ala1513Val)
MISSENSE
rs61732768 Benign: not provided 122,718,389(+) A/C
NM_017554.3(PARP14):c.4238A>C (p.Gln1413Pro)
MISSENSE
rs863223384 Benign: Abnormality of neuronal migration 122,700,009(+) T/A
NM_017554.3(PARP14):c.1455T>A (p.Ser485Arg)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP14 Gene

Variant ID Type Subtype PubMed ID
esv3304363 CNV mobile element insertion 20981092
esv3309593 CNV mobile element insertion 20981092
esv3370677 CNV insertion 20981092
nsv829705 CNV loss 17160897

Variation tolerance for PARP14 Gene

Residual Variation Intolerance Score: 3.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP14
Leiden Open Variation Database (LOVD)
PARP14

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP14 Gene

Disorders for PARP14 Gene

Additional Disease Information for PARP14

No disorders were found for PARP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP14 Gene

Publications for PARP14 Gene

  1. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. (PMID: 27796300) Iwata H … Aikawa M (Nature communications 2016) 3 4
  2. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  3. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst AH … Lüscher B (Structure (London, England : 1993) 2013) 3 4
  4. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. (PMID: 18851833) Kleine H … Lüscher B (Molecular cell 2008) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4

Products for PARP14 Gene

Sources for PARP14 Gene