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Aliases for PARP14 Gene

Aliases for PARP14 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 14 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 8 3 4
  • B Aggressive Lymphoma Protein 2 3 4
  • PARP-14 3 4
  • ARTD8 3 4
  • BAL2 3 4
  • Poly [ADP-Ribose] Polymerase 14 3
  • B-Aggressive Lymphoma 2 3
  • Collaborator Of STAT6 3
  • EC 2.4.2.30 4
  • KIAA1268 4
  • PART8 3

External Ids for PARP14 Gene

Previous GeneCards Identifiers for PARP14 Gene

  • GC03P123897
  • GC03P122399
  • GC03P119772

Summaries for PARP14 Gene

Entrez Gene Summary for PARP14 Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

GeneCards Summary for PARP14 Gene

PARP14 (Poly(ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Among its related pathways are Metabolism and NAD metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot for PARP14 Gene

  • ADP-ribosyltransferase (PubMed:16061477, PubMed:27796300). By mono-ADP-ribosylating STAT1 at Glu-657 and Glu-705 and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).

Tocris Summary for PARP14 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Additional gene information for PARP14 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP14 Gene

Genomics for PARP14 Gene

GeneHancer (GH) Regulatory Elements for PARP14 Gene

Promoters and enhancers for PARP14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J122678 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 674.3 +0.7 680 5.9 HDGF SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ATF7 RUNX3 PARP14 DTX3L PARP9 HSPBAP1 DIRC2 LINC02035 CSTA KPNA1
GH03J122718 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.3 +37.8 37807 0.1 PARP14 HSPBAP1 DIRC2
GH03J122792 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.7 +113.8 113808 3.9 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF213 HSPBAP1 DIRC2 ENSG00000273454 IQCB1 PARP14 SEC22A LOC102723582 LINC02035
GH03J122766 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 31.1 +87.7 87703 3.8 POLR2A DIRC2 HSPBAP1 PARP14 PARP9 DTX3L LINC02035 CSTA KPNA1
GH03J122562 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.1 -116.1 -116148 3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF143 ZNF263 SP3 DTX3L PARP9 LOC102723582 IQCB1 SEC22A GOLGB1 PARP14 WDR5B KPNA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARP14 gene promoter:
  • GATA-2
  • IRF-1
  • c-Ets-1
  • CUTL1
  • Meis-1
  • LCR-F1
  • Meis-1a
  • Meis-1b
  • GATA-1
  • c-Myb

Genomic Locations for PARP14 Gene

Genomic Locations for PARP14 Gene
chr3:122,680,618-122,730,840
(GRCh38/hg38)
Size:
50,223 bases
Orientation:
Plus strand
chr3:122,399,465-122,449,687
(GRCh37/hg19)
Size:
50,223 bases
Orientation:
Plus strand

Genomic View for PARP14 Gene

Genes around PARP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP14 Gene

Proteins for PARP14 Gene

  • Protein details for PARP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q460N5-PAR14_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 14
    Protein Accession:
    Q460N5
    Secondary Accessions:
    • B4E2H0
    • Q460N4
    • Q8J027
    • Q9H9X9
    • Q9NV60
    • Q9ULF2

    Protein attributes for PARP14 Gene

    Size:
    1801 amino acids
    Molecular mass:
    202800 Da
    Quaternary structure:
    • Interacts with STAT6 (By similarity). Interacts with PARP10 (PubMed:23473667). Interacts with PARP9 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP-riboslylation (PubMed:27796300).
    SequenceCaution:
    • Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DB237115; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP14 Gene

    Alternative splice isoforms for PARP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP14 Gene

Post-translational modifications for PARP14 Gene

  • Auto-ADP-ribosylated.
  • Ubiquitination at isoforms=3, 5, 61589, isoforms=3, 4, 5, 61508, Lys1435, isoforms=3, 4, 5, 61319, Lys1201, Lys1122, Lys967, isoforms=3, 4, 6939, Lys924, Lys773, isoforms=3, 4, 6747, Lys640, Lys518, and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for PARP14 Gene

No data available for DME Specific Peptides for PARP14 Gene

Domains & Families for PARP14 Gene

Gene Families for PARP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PARP14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP14: view

No data available for UniProtKB/Swiss-Prot for PARP14 Gene

Function for PARP14 Gene

Molecular function for PARP14 Gene

UniProtKB/Swiss-Prot Function:
ADP-ribosyltransferase (PubMed:16061477, PubMed:27796300). By mono-ADP-ribosylating STAT1 at Glu-657 and Glu-705 and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG in macrophages. Down-regulated by IL4 in macrophages.

Enzyme Numbers (IUBMB) for PARP14 Gene

Phenotypes From GWAS Catalog for PARP14 Gene

Gene Ontology (GO) - Molecular Function for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 27796300
GO:0005515 protein binding IPI 23473667
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PARP14: view
genes like me logo Genes that share phenotypes with PARP14: view

Animal Model Products

miRNA for PARP14 Gene

miRTarBase miRNAs that target PARP14

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP14 Gene

Localization for PARP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP14 Gene

Nucleus. Cytoplasm. Note=In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm (PubMed:27796300). {ECO:0000250 UniProtKB:Q2EMV9, ECO:0000269 PubMed:27796300}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP14 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 27796300
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PARP14: view

Pathways & Interactions for PARP14 Gene

genes like me logo Genes that share pathways with PARP14: view

Gene Ontology (GO) - Biological Process for PARP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006471 protein ADP-ribosylation IDA 27796300
GO:0010629 negative regulation of gene expression IMP 27796300
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP 27796300
genes like me logo Genes that share ontologies with PARP14: view

No data available for SIGNOR curated interactions for PARP14 Gene

Drugs & Compounds for PARP14 Gene

(4) Drugs for PARP14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Nutra 942,946
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist, Activator 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP14 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP14 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP14: view

Transcripts for PARP14 Gene

mRNA/cDNA for PARP14 Gene

Unigene Clusters for PARP14 Gene

Poly (ADP-ribose) polymerase family, member 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP14 Gene

No ASD Table

Relevant External Links for PARP14 Gene

GeneLoc Exon Structure for
PARP14
ECgene alternative splicing isoforms for
PARP14

Expression for PARP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP14 Gene

Protein differential expression in normal tissues from HIPED for PARP14 Gene

This gene is overexpressed in Lymph node (17.5), Lavage (12.8), Peripheral blood mononuclear cells (9.5), and Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP14 Gene



Protein tissue co-expression partners for PARP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of PARP14 Gene:

PARP14

SOURCE GeneReport for Unigene cluster for PARP14 Gene:

Hs.518203

mRNA Expression by UniProt/SwissProt for PARP14 Gene:

Q460N5-PAR14_HUMAN
Tissue specificity: Expressed in macrophages.

Evidence on tissue expression from TISSUES for PARP14 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Lung(2.6)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PARP14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP14 Gene

Orthologs for PARP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP14 34 33
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PARP14 34 33
  • 81.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PARP14 34 33
  • 78.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp14 33
  • 73.78 (n)
mouse
(Mus musculus)
Mammalia Parp14 16 34 33
  • 73.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PARP14 33
  • 56.65 (n)
-- 34
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732564 33
  • 51.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19831 33
zebrafish
(Danio rerio)
Actinopterygii parp14 33
  • 49.63 (n)
CABZ01031892.1 34
  • 34 (a)
ManyToMany
si:ch211-219a4.3 34
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for PARP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP14 Gene

ENSEMBL:
Gene Tree for PARP14 (if available)
TreeFam:
Gene Tree for PARP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP14: view image

Paralogs for PARP14 Gene

Paralogs for PARP14 Gene

(1) SIMAP similar genes for PARP14 Gene using alignment to 5 proteins:

  • PAR14_HUMAN
  • D3DN94_HUMAN
  • H7C4Y3_HUMAN
  • H7C5R8_HUMAN
  • Q8N546_HUMAN

Pseudogenes.org Pseudogenes for PARP14 Gene

genes like me logo Genes that share paralogs with PARP14: view

Variants for PARP14 Gene

Sequence variations from dbSNP and Humsavar for PARP14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs863223384 benign, Abnormality of neuronal migration 122,700,009(+) T/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs863223385 benign, Abnormality of neuronal migration 122,700,637(+) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000007837 -- 122,703,196(+) C/T intron_variant
rs1000069467 -- 122,693,558(+) G/A/C intron_variant
rs1000314909 -- 122,713,167(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PARP14 Gene

Variant ID Type Subtype PubMed ID
esv3304363 CNV mobile element insertion 20981092
esv3309593 CNV mobile element insertion 20981092
esv3370677 CNV insertion 20981092
nsv829705 CNV loss 17160897

Variation tolerance for PARP14 Gene

Residual Variation Intolerance Score: 3.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP14 Gene

Disorders for PARP14 Gene

Additional Disease Information for PARP14

No disorders were found for PARP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP14 Gene

Publications for PARP14 Gene

  1. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. (PMID: 27796300) Iwata H … Aikawa M (Nature communications 2016) 3 4 58
  2. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst AH … Lüscher B (Structure (London, England : 1993) 2013) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4 58
  4. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PMID: 16061477) Aguiar RC … Shipp MA (The Journal of biological chemistry 2005) 3 4 58
  5. The PARP superfamily. (PMID: 15273990) Amé JC … de Murcia G (BioEssays : news and reviews in molecular, cellular and developmental biology 2004) 2 3 58

Products for PARP14 Gene

Sources for PARP14 Gene

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