Aliases for PARP12 Gene

Aliases for PARP12 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 12 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP12 3 4
  • Poly [ADP-Ribose] Polymerase 12 3 4
  • ZC3HDC1 3 4
  • ARTD12 3 4
  • Zinc Finger CCCH Domain-Containing Protein 1 4
  • Zinc Finger CCCH Type Domain Containing 1 3
  • Zinc Finger CCCH-Type Domain Containing 1 2
  • EC 2.4.2.- 4
  • MSTP109 3
  • PARP-12 4
  • MST109 3
  • ZC3H1 3

External Ids for PARP12 Gene

Previous HGNC Symbols for PARP12 Gene

  • ZC3HDC1

Previous GeneCards Identifiers for PARP12 Gene

  • GC07M139177
  • GC07M139370
  • GC07M139723
  • GC07M134017

Summaries for PARP12 Gene

GeneCards Summary for PARP12 Gene

PARP12 (Poly(ADP-Ribose) Polymerase Family Member 12) is a Protein Coding gene. Diseases associated with PARP12 include Osebold-Remondini Syndrome. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ZC3HAV1.

UniProtKB/Swiss-Prot Summary for PARP12 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Tocris Summary for PARP12 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP12 Gene

Additional gene information for PARP12 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP12 Gene

Genomics for PARP12 Gene

GeneHancer (GH) Regulatory Elements for PARP12 Gene

Promoters and enhancers for PARP12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP12

Top Transcription factor binding sites by QIAGEN in the PARP12 gene promoter:
  • AP-4
  • E2F
  • E2F-1
  • POU2F1
  • POU2F1a
  • RP58
  • Zic1
  • ZID

Genomic Locations for PARP12 Gene

Genomic Locations for PARP12 Gene
chr7:140,023,744-140,063,828
(GRCh38/hg38)
Size:
40,085 bases
Orientation:
Minus strand
chr7:139,723,544-139,763,521
(GRCh37/hg19)
Size:
39,978 bases
Orientation:
Minus strand

Genomic View for PARP12 Gene

Genes around PARP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP12 Gene

Proteins for PARP12 Gene

  • Protein details for PARP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0J9-PAR12_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP12
    Protein Accession:
    Q9H0J9
    Secondary Accessions:
    • Q9H610
    • Q9NP36
    • Q9NTI3

    Protein attributes for PARP12 Gene

    Size:
    701 amino acids
    Molecular mass:
    79064 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PARP12 Gene

neXtProt entry for PARP12 Gene

Post-translational modifications for PARP12 Gene

No data available for DME Specific Peptides for PARP12 Gene

Domains & Families for PARP12 Gene

Gene Families for PARP12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PARP12 Gene

Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARP12 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger CCCH type domain containing 1 (A4D1T0_HUMAN)
  • Zinc finger CCCH domain-containing protein 1 (PAR12_HUMAN)
  • MSTP109 (Q7Z2T1_HUMAN)
genes like me logo Genes that share domains with PARP12: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP12 Gene

Function for PARP12 Gene

Molecular function for PARP12 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54425; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56613; Evidence=. ;.

Enzyme Numbers (IUBMB) for PARP12 Gene

Phenotypes From GWAS Catalog for PARP12 Gene

Gene Ontology (GO) - Molecular Function for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PARP12: view
genes like me logo Genes that share phenotypes with PARP12: view

Animal Models for PARP12 Gene

MGI Knock Outs for PARP12:
  • Parp12 Parp12<tm1.1(KOMP)Vlcg>

miRNA for PARP12 Gene

miRTarBase miRNAs that target PARP12

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP12 Gene

Localization for PARP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP12 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PARP12: view

Pathways & Interactions for PARP12 Gene

PathCards logo

SuperPathways for PARP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070213 protein auto-ADP-ribosylation IDA 25043379
genes like me logo Genes that share ontologies with PARP12: view

No data available for Pathways by source and SIGNOR curated interactions for PARP12 Gene

Drugs & Compounds for PARP12 Gene

(4) Drugs for PARP12 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 526,526
NAD Experimental Pharma Full agonist, Agonist, Activator 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP12 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP12: view

Transcripts for PARP12 Gene

mRNA/cDNA for PARP12 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for PARP12 Gene

GeneLoc Exon Structure for
PARP12

Expression for PARP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARP12 Gene

This gene is overexpressed in Lymph node (21.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP12 Gene



Protein tissue co-expression partners for PARP12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP12

SOURCE GeneReport for Unigene cluster for PARP12 Gene:

Hs.12646

Evidence on tissue expression from TISSUES for PARP12 Gene

  • Intestine(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PARP12: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP12 Gene

Orthologs for PARP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP12 31 30
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PARP12 31 30
  • 86.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp12 30
  • 82.93 (n)
mouse
(Mus musculus)
Mammalia Parp12 17 31 30
  • 82.88 (n)
cow
(Bos Taurus)
Mammalia PARP12 31 30
  • 82.07 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP12 31
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP12 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP12 31 30
  • 61.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP12 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489821 30
  • 58.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12414 30
zebrafish
(Danio rerio)
Actinopterygii parp12a 31 30
  • 55.61 (n)
OneToMany
PARP12 (2 of 2) 31
  • 34 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9609 30
Species where no ortholog for PARP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP12 Gene

ENSEMBL:
Gene Tree for PARP12 (if available)
TreeFam:
Gene Tree for PARP12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP12: view image

Paralogs for PARP12 Gene

Paralogs for PARP12 Gene

(4) SIMAP similar genes for PARP12 Gene using alignment to 5 proteins:

  • PAR12_HUMAN
  • G5E9U9_HUMAN
  • H7C4L8_HUMAN
  • H7C4T3_HUMAN
  • H7C4Z9_HUMAN
genes like me logo Genes that share paralogs with PARP12: view

Variants for PARP12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP12 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
724739 Benign: not provided 140,037,782(-) C/A SYNONYMOUS_VARIANT
783510 Benign: not provided 140,041,773(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
783511 Benign: not provided 140,058,002(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs17161356 - p.Ala620Val
rs34111764 - p.Val293Ile

Additional dbSNP identifiers (rs#s) for PARP12 Gene

Structural Variations from Database of Genomic Variants (DGV) for PARP12 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv2735237 CNV deletion 23290073
esv2735238 CNV deletion 23290073
esv2735240 CNV deletion 23290073
esv2735241 CNV deletion 23290073
nsv1076005 CNV deletion 25765185
nsv1119141 CNV deletion 24896259
nsv824318 CNV loss 20364138

Variation tolerance for PARP12 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP12 Gene

Disorders for PARP12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PARP12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osebold-remondini syndrome
  • brachymesophalangy with mesomelic short limbs and carpal and tarsal osseous abnormalities
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PARP12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PARP12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP12 Gene

Publications for PARP12 Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 23 54
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
  3. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4 54
  4. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M … Meschia JF (Stroke 2009) 3 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for PARP12 Gene

Sources for PARP12 Gene