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Aliases for PARP12 Gene

Aliases for PARP12 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 12 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3 4
  • ZC3HDC1 3 4
  • ARTD12 3 4
  • Zinc Finger CCCH Domain-Containing Protein 1 4
  • Zinc Finger CCCH Type Domain Containing 1 3
  • Zinc Finger CCCH-Type Domain Containing 1 2
  • Poly [ADP-Ribose] Polymerase 12 3
  • EC 4
  • MSTP109 3
  • PARP-12 4
  • MST109 3
  • ZC3H1 3

External Ids for PARP12 Gene

Previous HGNC Symbols for PARP12 Gene

  • ZC3HDC1

Previous GeneCards Identifiers for PARP12 Gene

  • GC07M139177
  • GC07M139370
  • GC07M139723
  • GC07M134017

Summaries for PARP12 Gene

GeneCards Summary for PARP12 Gene

PARP12 (Poly(ADP-Ribose) Polymerase Family Member 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ZC3HAV1.

Tocris Summary for PARP12 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP12 Gene

Additional gene information for PARP12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP12 Gene

Genomics for PARP12 Gene

GeneHancer (GH) Regulatory Elements for PARP12 Gene

Promoters and enhancers for PARP12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J140058 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 667.7 +2.4 2382 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 FOS PARP12 LUC7L2 SLC37A3 UBN2 BRAF TTC26 GC07P140023 GC07P140024
GH07J139101 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.8 +956.3 956341 11.2 FEZF1 DMAP1 YBX1 YY1 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 TTC26 ZC3HAV1 LUC7L2 UBN2 ZC3HAV1L PARP12 RPL17P28 GC07P138894
GH07J139773 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.8 +287.6 287597 5.5 HDGF PKNOX1 SIN3A ZNF2 IRF4 YY1 ZNF143 ZNF207 FOS KLF13 TBXAS1 HIPK2 SLC37A3 LUC7L2 ZC3HAV1L PARP12 PIR36040
GH07J140637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.8 -576.0 -576011 5.6 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF416 KLF7 ATF7 KLF13 LOC105375535 DENND2A CCT4P1 RNU4-74P SLC37A3 NDUFB2 NDUFB2-AS1 BRAF PARP12 ADCK2
GH07J139724 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +331.7 331685 15 HDGF CLOCK FOXA2 ZFP64 ZNF133 ARID4B SIN3A FEZF1 ZNF2 IRF4 SLC37A3 LUC7L2 TBXAS1 HIPK2 UBN2 ZC3HAV1L PARP12 KDM7A TMEM213 KIAA1549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PARP12 gene promoter:
  • ZID
  • AP-4
  • POU2F1a
  • POU2F1
  • E2F
  • E2F-1
  • RP58
  • Zic1

Genomic Locations for PARP12 Gene

Genomic Locations for PARP12 Gene
40,085 bases
Minus strand
39,978 bases
Minus strand

Genomic View for PARP12 Gene

Genes around PARP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP12 Gene

Proteins for PARP12 Gene

  • Protein details for PARP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 12
    Protein Accession:
    Secondary Accessions:
    • Q9H610
    • Q9NP36
    • Q9NTI3

    Protein attributes for PARP12 Gene

    701 amino acids
    Molecular mass:
    79064 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PARP12 Gene

neXtProt entry for PARP12 Gene

Post-translational modifications for PARP12 Gene

  • Ubiquitination at Lys477, Lys308, and Lys256
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARP12 Gene

Domains & Families for PARP12 Gene

Gene Families for PARP12 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PARP12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP12: view

No data available for UniProtKB/Swiss-Prot for PARP12 Gene

Function for PARP12 Gene

Molecular function for PARP12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP12 Gene

Phenotypes From GWAS Catalog for PARP12 Gene

Gene Ontology (GO) - Molecular Function for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PARP12: view
genes like me logo Genes that share phenotypes with PARP12: view

Animal Model Products

miRNA for PARP12 Gene

miRTarBase miRNAs that target PARP12

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARP12 Gene

Localization for PARP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP12 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PARP12: view

Pathways & Interactions for PARP12 Gene

SuperPathways for PARP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP12 Gene


No data available for Pathways by source and SIGNOR curated interactions for PARP12 Gene

Drugs & Compounds for PARP12 Gene

(4) Drugs for PARP12 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Nutra 942,946
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist, Activator 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for PARP12 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP12: view

Transcripts for PARP12 Gene

Unigene Clusters for PARP12 Gene

Poly (ADP-ribose) polymerase family, member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP8: - -

Relevant External Links for PARP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARP12 Gene

This gene is overexpressed in Lymph node (21.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP12 Gene

Protein tissue co-expression partners for PARP12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP12 Gene:


SOURCE GeneReport for Unigene cluster for PARP12 Gene:


Evidence on tissue expression from TISSUES for PARP12 Gene

  • Intestine(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PARP12: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP12 Gene

Orthologs for PARP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PARP12 34 33
  • 99.14 (n)
(Canis familiaris)
Mammalia PARP12 34 33
  • 86.12 (n)
(Rattus norvegicus)
Mammalia Parp12 33
  • 82.93 (n)
(Mus musculus)
Mammalia Parp12 16 34 33
  • 82.88 (n)
(Bos Taurus)
Mammalia PARP12 34 33
  • 82.07 (n)
(Ornithorhynchus anatinus)
Mammalia PARP12 34
  • 58 (a)
(Monodelphis domestica)
Mammalia PARP12 34
  • 50 (a)
(Gallus gallus)
Aves PARP12 34 33
  • 61.96 (n)
(Anolis carolinensis)
Reptilia PARP12 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489821 33
  • 58.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12414 33
(Danio rerio)
Actinopterygii parp12a 34 33
  • 55.61 (n)
PARP12 (2 of 2) 34
  • 34 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9609 33
Species where no ortholog for PARP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP12 Gene

Gene Tree for PARP12 (if available)
Gene Tree for PARP12 (if available)
Evolutionary constrained regions (ECRs) for PARP12: view image

Paralogs for PARP12 Gene

Paralogs for PARP12 Gene

(4) SIMAP similar genes for PARP12 Gene using alignment to 5 proteins:

  • G5E9U9_HUMAN
  • H7C4L8_HUMAN
  • H7C4T3_HUMAN
  • H7C4Z9_HUMAN
genes like me logo Genes that share paralogs with PARP12: view

Variants for PARP12 Gene

Sequence variations from dbSNP and Humsavar for PARP12 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000224259 -- 140,027,177(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000255674 -- 140,045,859(-) T/C intron_variant
rs1000360009 -- 140,060,998(-) A/C intron_variant
rs1000480471 -- 140,040,545(-) T/A intron_variant
rs1000524017 -- 140,063,117(-) G/A 5_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PARP12 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv2735237 CNV deletion 23290073
esv2735238 CNV deletion 23290073
esv2735240 CNV deletion 23290073
esv2735241 CNV deletion 23290073
nsv1076005 CNV deletion 25765185
nsv1119141 CNV deletion 24896259
nsv824318 CNV loss 20364138

Variation tolerance for PARP12 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP12 Gene

Disorders for PARP12 Gene

Additional Disease Information for PARP12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PARP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP12 Gene

Publications for PARP12 Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 22 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M … Meschia JF (Stroke 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PARP12 Gene

Sources for PARP12 Gene

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