Aliases for PARP11 Gene
External Ids for PARP11 Gene
Previous HGNC Symbols for PARP11 Gene
Previous GeneCards Identifiers for PARP11 Gene
GeneCards Summary for PARP11 Gene
PARP11 (Poly(ADP-Ribose) Polymerase Family Member 11) is a Protein Coding gene. Diseases associated with PARP11 include Osteogenesis Imperfecta, Type Xx and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Granzyme Pathway and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP12.
UniProtKB/Swiss-Prot Summary for PARP11 Gene
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.