Aliases for PARP11 Gene

Aliases for PARP11 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 11 2 3 5
  • ARTD11 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 11 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP11 3 4
  • Poly [ADP-Ribose] Polymerase 11 3 4
  • C12orf6 3 4
  • Chromosome 12 Open Reading Frame 6 2
  • EC 2.4.2.- 4
  • PARP-11 4
  • MIB006 3
  • PARP11 5

External Ids for PARP11 Gene

Previous HGNC Symbols for PARP11 Gene

  • C12orf6

Previous GeneCards Identifiers for PARP11 Gene

  • GC12M003792
  • GC12M003900
  • GC12M003939
  • GC12M003966
  • GC12M003970
  • GC12M004036
  • GC12M003794
  • GC12M003825
  • GC12M003855
  • GC12M003888
  • GC12M003918
  • GC12M004104
  • GC12M004176

Summaries for PARP11 Gene

GeneCards Summary for PARP11 Gene

PARP11 (Poly(ADP-Ribose) Polymerase Family Member 11) is a Protein Coding gene. Diseases associated with PARP11 include Osteogenesis Imperfecta, Type Xx and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Granzyme Pathway and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot Summary for PARP11 Gene

  • Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).

Tocris Summary for PARP11 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP11 Gene

Genomics for PARP11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP11

Top Transcription factor binding sites by QIAGEN in the PARP11 gene promoter:
  • C/EBPbeta
  • Chx10
  • Evi-1
  • FOXO4
  • IRF-2
  • LCR-F1
  • Lmo2
  • MAZR
  • RSRFC4
  • STAT3

Genomic Locations for PARP11 Gene

Latest Assembly
chr12:3,791,047-3,873,471
(GRCh38/hg38)
Size:
82,425 bases
Orientation:
Minus strand

Previous Assembly
chr12:3,918,027-3,982,565
(GRCh37/hg19 by Entrez Gene)
Size:
64,539 bases
Orientation:
Minus strand

chr12:3,900,213-3,982,608
(GRCh37/hg19 by Ensembl)
Size:
82,396 bases
Orientation:
Minus strand

Genomic View for PARP11 Gene

Genes around PARP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP11 Gene

Proteins for PARP11 Gene

  • Protein details for PARP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR21-PAR11_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP11
    Protein Accession:
    Q9NR21
    Secondary Accessions:
    • B4DRQ0
    • F8WBZ7
    • Q68DS1
    • Q8N5Y9

    Protein attributes for PARP11 Gene

    Size:
    338 amino acids
    Molecular mass:
    39597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17569.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH31073.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for PARP11 Gene

    Alternative splice isoforms for PARP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARP11 Gene

Post-translational modifications for PARP11 Gene

No data available for DME Specific Peptides for PARP11 Gene

Domains & Families for PARP11 Gene

Gene Families for PARP11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP11 Gene

Suggested Antigen Peptide Sequences for PARP11 Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 11 (PAR11_HUMAN)
genes like me logo Genes that share domains with PARP11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PARP11 Gene

Function for PARP11 Gene

Molecular function for PARP11 Gene

UniProtKB/Swiss-Prot Function:
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence={ECO:0000269|PubMed:25043379};.

Enzyme Numbers (IUBMB) for PARP11 Gene

Phenotypes From GWAS Catalog for PARP11 Gene

Gene Ontology (GO) - Molecular Function for PARP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 25673562
GO:0005515 protein binding IPI --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:1990404 protein ADP-ribosylase activity IDA 25043379
genes like me logo Genes that share ontologies with PARP11: view
genes like me logo Genes that share phenotypes with PARP11: view

Animal Models for PARP11 Gene

MGI Knock Outs for PARP11:
  • Parp11 Parp11<tm1.1(KOMP)Vlcg>
  • Parp11 Parp11<tm1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP11

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP11 Gene

Localization for PARP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP11 Gene

Nucleus, nuclear pore complex. Note=Colocalizes with NUP153 at nuclear pores. {ECO:0000269 PubMed:25673562}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP11 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 25673562
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PARP11: view

Pathways & Interactions for PARP11 Gene

PathCards logo

SuperPathways for PARP11 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
2 all-trans-Retinoic Acid Mediated Apoptosis
-
3 Apoptotic Pathways in Synovial Fibroblasts
.85
4 Granzyme Pathway
-
5 UVA-Induced MAPK Signaling
.38
genes like me logo Genes that share pathways with PARP11: view

Pathways by source for PARP11 Gene

1 Sino Biological pathway for PARP11 Gene
4 Qiagen pathways for PARP11 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IEA --
GO:0007283 spermatogenesis IEA --
GO:0015031 protein transport IEA --
GO:0030154 cell differentiation IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with PARP11: view

No data available for SIGNOR curated interactions for PARP11 Gene

Drugs & Compounds for PARP11 Gene

(5) Drugs for PARP11 Gene - From: PharmGKB, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
antidepressants Pharma 0
4-HQN Pharma PARP inhibitor 0

(1) Additional Compounds for PARP11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP11 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2
genes like me logo Genes that share compounds with PARP11: view

Transcripts for PARP11 Gene

mRNA/cDNA for PARP11 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP11

Alternative Splicing Database (ASD) splice patterns (SP) for PARP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:

Relevant External Links for PARP11 Gene

GeneLoc Exon Structure for
PARP11

Expression for PARP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP11

SOURCE GeneReport for Unigene cluster for PARP11 Gene:

Hs.657268

Evidence on tissue expression from TISSUES for PARP11 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with PARP11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP11 Gene

Orthologs for PARP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARP11 29 30
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PARP11 29 30
  • 91.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Parp11 29
  • 89.22 (n)
Mouse
(Mus musculus)
Mammalia Parp11 29 16 30
  • 88.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PARP11 29 30
  • 88.35 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PARP11 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PARP11 29 30
  • 79.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARP11 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia parp11 29
  • 69.54 (n)
Str.17739 29
Zebrafish
(Danio rerio)
Actinopterygii CU639413.2 30
  • 5 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 20 (a)
OneToMany
Species where no ortholog for PARP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP11 Gene

ENSEMBL:
Gene Tree for PARP11 (if available)
TreeFam:
Gene Tree for PARP11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP11: view image
Alliance of Genome Resources:
Additional Orthologs for PARP11

Paralogs for PARP11 Gene

Paralogs for PARP11 Gene

(2) SIMAP similar genes for PARP11 Gene using alignment to 5 proteins:

  • PAR11_HUMAN
  • F5H8L8_HUMAN
  • F8WBZ7_HUMAN
  • F8WFA3_HUMAN
  • G3V0I3_HUMAN
genes like me logo Genes that share paralogs with PARP11: view

Variants for PARP11 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP11 Gene

Variant ID Type Subtype PubMed ID
nsv1036828 CNV gain 25217958
nsv468981 CNV gain 19166990
nsv483060 CNV loss 15286789
nsv557116 CNV gain 21841781
nsv832313 CNV loss 17160897
nsv832316 CNV gain 17160897
nsv976558 CNV duplication 23825009

Variation tolerance for PARP11 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP11
Leiden Open Variation Database (LOVD)
PARP11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP11 Gene

Disorders for PARP11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP11 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PARP11

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PARP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP11 Gene

Publications for PARP11 Gene

  1. Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. (PMID: 25673562) Meyer-Ficca ML … Meyer RG (Biology of reproduction 2015) 3 4
  2. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PARP11 Gene

Sources for PARP11 Gene