Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008] See more...

Aliases for PARP10 Gene

Aliases for PARP10 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 10 2 3 5
  • ARTD10 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 10 3 4
  • Protein Mono-ADP-Ribosyltransferase PARP10 3 4
  • Poly [ADP-Ribose] Polymerase 10 3 4
  • EC 2.4.2.- 4
  • FLJ14464 2
  • PARP-10 4
  • PARP10 5

External Ids for PARP10 Gene

Previous GeneCards Identifiers for PARP10 Gene

  • GC08M145123
  • GC08M145051
  • GC08M140305

Summaries for PARP10 Gene

Entrez Gene Summary for PARP10 Gene

  • Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PARP10 Gene

PARP10 (Poly(ADP-Ribose) Polymerase Family Member 10) is a Protein Coding gene. Diseases associated with PARP10 include Diphtheria and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include nucleotide binding and K63-linked polyubiquitin modification-dependent protein binding. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot Summary for PARP10 Gene

  • ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).

Tocris Summary for PARP10 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARP10 Gene

Genomics for PARP10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARP10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARP10

Top Transcription factor binding sites by QIAGEN in the PARP10 gene promoter:
  • c-Myc
  • Max1
  • MyoD

Genomic Locations for PARP10 Gene

Latest Assembly
chr8:143,977,153-144,012,772
(GRCh38/hg38)
Size:
35,620 bases
Orientation:
Minus strand

Previous Assembly
chr8:145,051,326-145,060,628
(GRCh37/hg19 by Entrez Gene)
Size:
9,303 bases
Orientation:
Minus strand

chr8:145,051,321-145,086,940
(GRCh37/hg19 by Ensembl)
Size:
35,620 bases
Orientation:
Minus strand

Genomic View for PARP10 Gene

Genes around PARP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP10 Gene

Proteins for PARP10 Gene

  • Protein details for PARP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GL7-PAR10_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase PARP10
    Protein Accession:
    Q53GL7
    Secondary Accessions:
    • Q8N2I0
    • Q8WV05
    • Q96CH7
    • Q96K72

    Protein attributes for PARP10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    109998 Da
    Quaternary structure:
    • Interacts with MYC (PubMed:15674325). Interacts with PARP14 (PubMed:23473667). Interacts (via-PIP box and ubiquitin-interacting motifs) with PCNA (PubMed:24695737).
    SequenceCaution:
    • Sequence=BAC11498.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PARP10 Gene

neXtProt entry for PARP10 Gene

Post-translational modifications for PARP10 Gene

  • Stimulated through its phosphorylation by CDK2 (PubMed:16455663). Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions (PubMed:16455663). Phosphorylation is suppressed in growth-arrested cells (PubMed:16455663).
  • Auto-mono-ADP-ribosylated on glutamate and lysine residues.
  • Ubiquitination at Lys426, Lys436, Lys814, Lys916, and Lys941
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARP10 Gene

Domains & Families for PARP10 Gene

Gene Families for PARP10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PARP10 Gene

InterPro:
Blocks:
  • Ubiquitin interacting motif

Suggested Antigen Peptide Sequences for PARP10 Gene

GenScript: Design optimal peptide antigens:
  • Poly (ADP-ribose) polymerase family, member 10 (A2RUM0_HUMAN)
  • Poly [ADP-ribose] polymerase 10 (PAR10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53GL7

UniProtKB/Swiss-Prot:

PAR10_HUMAN :
  • The PIP-box mediates the interaction with PCNA.
Domain:
  • The PIP-box mediates the interaction with PCNA.
genes like me logo Genes that share domains with PARP10: view

Function for PARP10 Gene

Molecular function for PARP10 Gene

UniProtKB/Swiss-Prot Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58220, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15088, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:142515; Evidence={ECO:0000269|PubMed:25043379};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:18851833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:25043379};.

Enzyme Numbers (IUBMB) for PARP10 Gene

Phenotypes From GWAS Catalog for PARP10 Gene

Gene Ontology (GO) - Molecular Function for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA 21873635
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,IMP 23473667
GO:0005515 protein binding IPI 15674325
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PARP10: view
genes like me logo Genes that share phenotypes with PARP10: view

Animal Models for PARP10 Gene

MGI Knock Outs for PARP10:

miRNA for PARP10 Gene

miRTarBase miRNAs that target PARP10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP10 Gene

Localization for PARP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP10 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325). {ECO:0000269 PubMed:15674325}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP10 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli rim (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 15674325
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA,IDA 15674325
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with PARP10: view

Pathways & Interactions for PARP10 Gene

genes like me logo Genes that share pathways with PARP10: view

Pathways by source for PARP10 Gene

4 Qiagen pathways for PARP10 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cellular Apoptosis Pathway
  • Granzyme Pathway
  • UVA-Induced MAPK Signaling

Gene Ontology (GO) - Biological Process for PARP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006471 protein ADP-ribosylation IMP 23575687
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0010629 negative regulation of gene expression IBA,IMP 23575687
GO:0010847 regulation of chromatin assembly IDA 15674325
genes like me logo Genes that share ontologies with PARP10: view

No data available for SIGNOR curated interactions for PARP10 Gene

Drugs & Compounds for PARP10 Gene

(9) Drugs for PARP10 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
NU1025 Experimental Pharma PARP inhibitor,potent and novel, Potent PARP inhibitor 0
INO-1001 Investigational Pharma Potent PARP inhibitor 0
AG-14361 Pharma Potent PARP1 inhibitor 0

(1) Additional Compounds for PARP10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminobenzamide
3544-24-9

(3) Tocris Compounds for PARP10 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
NU 1025 Potent PARP inhibitor 90417-38-2

(5) ApexBio Compounds for PARP10 Gene

Compound Action Cas Number
AG-14361 Potent PARP1 inhibitor 328543-09-5
Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered 160003-66-7
INO-1001 Potent PARP inhibitor 3544-24-9
ME0328 PARP inhibitor,potent and selective 1445251-22-8
UPF 1069 Selective PARP2 inhibitor 1048371-03-4
genes like me logo Genes that share compounds with PARP10: view

Drug products for research

Transcripts for PARP10 Gene

mRNA/cDNA for PARP10 Gene

2 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARP10

Alternative Splicing Database (ASD) splice patterns (SP) for PARP10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - -
SP2:
SP3:
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

ExUns: 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PARP10 Gene

GeneLoc Exon Structure for
PARP10

Expression for PARP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Thymus (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for PARP10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.1) and CD8 Tcells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARP10 Gene



Protein tissue co-expression partners for PARP10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARP10

SOURCE GeneReport for Unigene cluster for PARP10 Gene:

Hs.348609

mRNA Expression by UniProt/SwissProt for PARP10 Gene:

Q53GL7-PAR10_HUMAN
Tissue specificity: Highly expressed in spleen and thymus (PubMed:15674325). Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325). Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325).

Evidence on tissue expression from TISSUES for PARP10 Gene

  • Skin(4.4)
  • Nervous system(4.4)
  • Kidney(4.4)
  • Liver(4.4)
  • Thyroid gland(4.2)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with PARP10: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP10 Gene

Orthologs for PARP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP10 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia PARP10 29 30
  • 77.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Parp10 29 16 30
  • 73.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102548778 29
  • 73.52 (n)
Oppossum
(Monodelphis domestica)
Mammalia PARP10 30
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PARP10 30
  • 48 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100494418 29
  • 49.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii PARP10 30
  • 22 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7657 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 25 (a)
OneToMany
Species where no ortholog for PARP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PARP10 Gene

ENSEMBL:
Gene Tree for PARP10 (if available)
TreeFam:
Gene Tree for PARP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARP10: view image
Alliance of Genome Resources:
Additional Orthologs for PARP10

Paralogs for PARP10 Gene

Paralogs for PARP10 Gene

genes like me logo Genes that share paralogs with PARP10: view

Variants for PARP10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARP10 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs141423961 Likely Benign: not provided 143,985,496(-) G/A
NM_032789.5(PARP10):c.589C>T (p.Arg197Cys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs141811386 Likely Benign: not provided 143,982,938(-) G/A
NM_032789.5(PARP10):c.2550C>T (p.Val850=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs146902781 Likely Benign: not provided 143,985,613(-) C/T
NM_032789.5(PARP10):c.472G>A (p.Gly158Ser)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1587459606 Likely Pathogenic: Developmental delay 143,985,436(-) CAG/C
NM_032789.5(PARP10):c.647_648del (p.Thr216fs)
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT
rs76489217 Benign: not provided 143,985,270(-) G/A
NM_032789.5(PARP10):c.732C>T (p.Val244=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARP10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARP10 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12432n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
esv1340913 CNV deletion 17803354
esv2738046 CNV deletion 23290073
esv2738047 CNV deletion 23290073
esv2738048 CNV deletion 23290073
esv2738049 CNV deletion 23290073
nsv1077076 CNV deletion 25765185
nsv1130887 CNV deletion 24896259
nsv1149362 CNV deletion 26484159
nsv1161815 CNV deletion 26073780
nsv470249 CNV loss 18288195
nsv470250 CNV gain 18288195
nsv472207 CNV novel sequence insertion 20440878
nsv472334 CNV novel sequence insertion 20440878
nsv475079 CNV novel sequence insertion 20440878
nsv475842 CNV novel sequence insertion 20440878
nsv476239 CNV novel sequence insertion 20440878
nsv479131 CNV novel sequence insertion 20440878
nsv479966 CNV novel sequence insertion 20440878
nsv480849 CNV novel sequence insertion 20440878
nsv481087 CNV novel sequence insertion 20440878
nsv481469 CNV novel sequence insertion 20440878
nsv515809 CNV gain+loss 19592680
nsv612906 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612914 CNV loss 21841781
nsv6445 CNV insertion 18451855
nsv950015 CNV deletion 24416366

Variation tolerance for PARP10 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARP10 Gene

Human Gene Mutation Database (HGMD)
PARP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP10
Leiden Open Variation Database (LOVD)
PARP10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP10 Gene

Disorders for PARP10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARP10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
diphtheria
  • corynebacterium infection
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PARP10

genes like me logo Genes that share disorders with PARP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARP10 Gene

Publications for PARP10 Gene

  1. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). (PMID: 16455663) Chou HY … Lee SC (The Journal of biological chemistry 2006) 3 4 22
  2. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4
  3. The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance. (PMID: 24695737) Nicolae CM … Moldovan GL (The Journal of biological chemistry 2014) 3 4
  4. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. (PMID: 23473667) Forst AH … Lüscher B (Structure (London, England : 1993) 2013) 3 4
  5. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. (PMID: 18851833) Kleine H … Lüscher B (Molecular cell 2008) 3 4

Products for PARP10 Gene

Sources for PARP10 Gene