Aliases for PARP10 Gene
External Ids for PARP10 Gene
Previous GeneCards Identifiers for PARP10 Gene
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PARP10 Gene
PARP10 (Poly(ADP-Ribose) Polymerase Family Member 10) is a Protein Coding gene. Diseases associated with PARP10 include Diphtheria and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Granzyme Pathway. Gene Ontology (GO) annotations related to this gene include nucleotide binding and K63-linked polyubiquitin modification-dependent protein binding. An important paralog of this gene is PARP14.
UniProtKB/Swiss-Prot Summary for PARP10 Gene
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.