Aliases for PARM1 Gene

Aliases for PARM1 Gene

  • Prostate Androgen-Regulated Mucin-Like Protein 1 2 3 4 5
  • Castration-Induced Prostatic Apoptosis-Related Protein 1 2 3
  • Prostatic Androgen-Repressed Message 1 2 3
  • PARM-1 3 4
  • WSC4, Cell Wall Integrity And Stress Response Component 4 Homolog (S. Cerevisiae) 2
  • WSC4, Cell Wall Integrity And Stress Response Component 4 Homolog 3
  • Prostatic Androgen-Regulated Mucin-Like Protein 1 3
  • DKFZP564O0823 3
  • Cipar1 3
  • WSC4 3

External Ids for PARM1 Gene

Previous GeneCards Identifiers for PARM1 Gene

  • GC04P076077
  • GC04P075858
  • GC04P071605

Summaries for PARM1 Gene

GeneCards Summary for PARM1 Gene

PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1) is a Protein Coding gene. Diseases associated with PARM1 include Exstrophy Of Bladder and Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex.

UniProtKB/Swiss-Prot Summary for PARM1 Gene

  • May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.

Gene Wiki entry for PARM1 Gene

Additional gene information for PARM1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARM1 Gene

Genomics for PARM1 Gene

GeneHancer (GH) Regulatory Elements for PARM1 Gene

Promoters and enhancers for PARM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J074932 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 504.5 +0.6 626 3.4 CTCF ZSCAN5C ZBTB10 ZBTB26 RAD21 EZH2 RELA POLR2A SMC3 ZNF341 PARM1 lnc-BTC-1 BTC KR153194-146
GH04J074962 Enhancer 0.4 FANTOM5 14.8 +28.5 28451 0.3 ZNF791 SETDB1 ZNF558 PARM1 THAP6 PARM1-AS1 KR153194-146
GH04J075342 Enhancer 0.8 Ensembl ENCODE 6.3 +411.3 411340 3.2 FOS ZEB1 BCL11A KLF13 PBX2 KLF8 JUND ZNF843 SCRT1 HIC1 PARM1 FAM47E LINC02483 ENSG00000251454 ENSG00000251185 piR-54764-491
GH04J074875 Enhancer 0.4 Ensembl 11.1 -57.7 -57674 0.4 CTCF NR2F2 SMC3 RAD21 PARM1 ENSG00000287375 LOC105377282 piR-31292-143
GH04J075029 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.9 +98.1 98062 2.5 RELA SPI1 IKZF1 HNF4A FOS IKZF2 EED GATAD2B PARM1 ENSG00000248165 piR-32810-083
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARM1

Genomic Locations for PARM1 Gene

Genomic Locations for PARM1 Gene
chr4:74,933,075-75,050,115
(GRCh38/hg38)
Size:
117,041 bases
Orientation:
Plus strand
chr4:75,858,285-75,975,325
(GRCh37/hg19)
Size:
117,041 bases
Orientation:
Plus strand

Genomic View for PARM1 Gene

Genes around PARM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARM1 Gene

Proteins for PARM1 Gene

  • Protein details for PARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWI2-PARM1_HUMAN
    Recommended name:
    Prostate androgen-regulated mucin-like protein 1
    Protein Accession:
    Q6UWI2
    Secondary Accessions:
    • B3KMQ9
    • Q96DV8
    • Q9Y4S1

    Protein attributes for PARM1 Gene

    Size:
    310 amino acids
    Molecular mass:
    32289 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB45720.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for PARM1 Gene

Post-translational modifications for PARM1 Gene

  • Highly N-glycosylated and O-glycosylated.
  • Glycosylation at Asn58, Asn62, Asn80, and Asn176
  • Modification sites at PhosphoSitePlus

Other Protein References for PARM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PARM1 Gene

Domains & Families for PARM1 Gene

Gene Families for PARM1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PARM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PARM1 Gene

GenScript: Design optimal peptide antigens:
  • Prostate androgen-regulated mucin-like protein 1 (PARM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWI2

UniProtKB/Swiss-Prot:

PARM1_HUMAN :
  • Belongs to the PARM family.
Family:
  • Belongs to the PARM family.
genes like me logo Genes that share domains with PARM1: view

Function for PARM1 Gene

Molecular function for PARM1 Gene

UniProtKB/Swiss-Prot Function:
May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.
UniProtKB/Swiss-Prot Induction:
By androgens.

Phenotypes From GWAS Catalog for PARM1 Gene

genes like me logo Genes that share phenotypes with PARM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PARM1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARM1 Gene

Localization for PARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARM1 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARM1 gene
Compartment Confidence
plasma membrane 5
endosome 5
golgi apparatus 5
nucleus 4
cytosol 4
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 18027867
genes like me logo Genes that share ontologies with PARM1: view

Pathways & Interactions for PARM1 Gene

PathCards logo

SuperPathways for PARM1 Gene

No Data Available

Interacting Proteins for PARM1 Gene

Selected Interacting proteins: Q6UWI2-PARM1_HUMAN for PARM1 Gene via IID

Symbol External ID(s) Details
TERF1
;

Gene Ontology (GO) - Biological Process for PARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051973 positive regulation of telomerase activity ISS --
genes like me logo Genes that share ontologies with PARM1: view

No data available for Pathways by source and SIGNOR curated interactions for PARM1 Gene

Drugs & Compounds for PARM1 Gene

No Compound Related Data Available

Transcripts for PARM1 Gene

mRNA/cDNA for PARM1 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARM1 Gene

No ASD Table

Relevant External Links for PARM1 Gene

GeneLoc Exon Structure for
PARM1

Expression for PARM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARM1 Gene

This gene is overexpressed in Testis (21.4), Fetal ovary (19.6), and Fetal heart (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PARM1 Gene



Protein tissue co-expression partners for PARM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARM1

SOURCE GeneReport for Unigene cluster for PARM1 Gene:

Hs.105460

mRNA Expression by UniProt/SwissProt for PARM1 Gene:

Q6UWI2-PARM1_HUMAN
Tissue specificity: Widely expressed with highest levels in heart, kidney and placenta.

Evidence on tissue expression from TISSUES for PARM1 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Pancreas(2.5)
  • Heart(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PARM1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARM1 Gene

Orthologs for PARM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARM1 31 30
  • 98.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PARM1 31
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARM1 30
  • 78.67 (n)
DKFZP564O0823 31
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parm1 17 31 30
  • 75.9 (n)
rat
(Rattus norvegicus)
Mammalia Parm1 30
  • 75.79 (n)
oppossum
(Monodelphis domestica)
Mammalia PARM1 31
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARM1 31
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARM1 31
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARM1 31
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PARM1 31
  • 25 (a)
OneToOne
Species where no ortholog for PARM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARM1 Gene

ENSEMBL:
Gene Tree for PARM1 (if available)
TreeFam:
Gene Tree for PARM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARM1: view image

Paralogs for PARM1 Gene

No data available for Paralogs for PARM1 Gene

Variants for PARM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARM1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
770713 Benign: not provided 75,012,704(+) G/C MISSENSE_VARIANT
rs3822109 - p.Ser127Leu

Additional dbSNP identifiers (rs#s) for PARM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PARM1 Gene

Variant ID Type Subtype PubMed ID
dgv2830n106 CNV deletion 24896259
esv3601022 CNV loss 21293372
nsv1074189 CNV deletion 25765185
nsv1150012 CNV deletion 26484159
nsv7363 OTHER inversion 18451855

Variation tolerance for PARM1 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARM1 Gene

Human Gene Mutation Database (HGMD)
PARM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARM1 Gene

Disorders for PARM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PARM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exstrophy of bladder
  • bladder exstrophy
bladder exstrophy-epispadias-cloacal exstrophy complex
  • eec
- elite association - COSMIC cancer census association via MalaCards
Search PARM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PARM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PARM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PARM1 Gene

Publications for PARM1 Gene

  1. Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells. (PMID: 18027867) Fladeby C … Bakke O (International journal of cancer 2008) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54

Products for PARM1 Gene

  • Signalway ELISA kits for PARM1
  • Signalway Proteins for PARM1

Sources for PARM1 Gene