Aliases for PARG Gene
External Ids for PARG Gene
Previous GeneCards Identifiers for PARG Gene
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
GeneCards Summary for PARG Gene
PARG (Poly(ADP-Ribose) Glycohydrolase) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include poly(ADP-ribose) glycohydrolase activity.
UniProtKB/Swiss-Prot for PARG Gene
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).