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PARD6G (Par-6 Family Cell Polarity Regulator Gamma) is a Protein Coding gene. Diseases associated with PARD6G include Myoclonic Epilepsy Associated With Ragged-Red Fibers. Among its related pathways are Hippo signaling pathway and Ras signaling pathway. An important paralog of this gene is PARD6B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005080 | protein kinase C binding | IBA | 21873635 |
GO:0005515 | protein binding | IEA,IPI | 11260256 |
GO:0031267 | small GTPase binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005923 | bicellular tight junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | G-protein signaling RAC1 in cellular process |
Cytoskeleton remodeling CDC42 in cellular processes
.37
|
G-protein signaling RAC1 in cellular process
.37
|
3 | Axon guidance | ||
4 | Endocytosis | ||
5 | Hippo signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0007098 | centrosome cycle | IBA | 21873635 |
GO:0007163 | establishment or maintenance of cell polarity | IEA,IBA | 21873635 |
GO:0051301 | cell division | IEA | -- |
GO:0060341 | regulation of cellular localization | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | 0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PARD6G 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PARD6G 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PARD6G 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pard6g 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pard6g 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PARD6G 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PARD6G 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PARD6G 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pard6g 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1701 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pard6gb 30 31 |
|
OneToMany | |
pard6ga 31 |
|
OneToMany | |||
Dr.27686 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010494 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | par-6 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | par-6 30 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7159 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
myoclonic epilepsy associated with ragged-red fibers |
|
|