This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008] See more...

Aliases for PARD6B Gene

Aliases for PARD6B Gene

  • Par-6 Family Cell Polarity Regulator Beta 2 3 5
  • Partitioning Defective 6 Homolog Beta 3 4
  • PAR-6 Beta 3 4
  • PAR-6B 2 4
  • PAR6B 3 4
  • Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta 2
  • Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans) 2
  • Par-6 Partitioning Defective 6 Homolog Beta 3
  • PARD6B 5

External Ids for PARD6B Gene

Previous GeneCards Identifiers for PARD6B Gene

  • GC20P049076
  • GC20P049986
  • GC20P050033
  • GC20P048781
  • GC20P049348
  • GC20P046096

Summaries for PARD6B Gene

Entrez Gene Summary for PARD6B Gene

  • This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PARD6B Gene

PARD6B (Par-6 Family Cell Polarity Regulator Beta) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Ras signaling pathway. An important paralog of this gene is PARD6G.

UniProtKB/Swiss-Prot Summary for PARD6B Gene

  • Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Gene Wiki entry for PARD6B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PARD6B Gene

Genomics for PARD6B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PARD6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PARD6B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PARD6B

Top Transcription factor binding sites by QIAGEN in the PARD6B gene promoter:
  • Arnt
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • Egr-4
  • NF-Y
  • Pax-5

Genomic Locations for PARD6B Gene

Latest Assembly
chr20:50,731,580-50,756,795
(GRCh38/hg38)
Size:
25,216 bases
Orientation:
Plus strand

Previous Assembly
chr20:49,348,117-49,370,278
(GRCh37/hg19 by Entrez Gene)
Size:
22,162 bases
Orientation:
Plus strand

chr20:49,348,081-49,373,332
(GRCh37/hg19 by Ensembl)
Size:
25,252 bases
Orientation:
Plus strand

Genomic View for PARD6B Gene

Genes around PARD6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARD6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARD6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARD6B Gene

Proteins for PARD6B Gene

  • Protein details for PARD6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG5-PAR6B_HUMAN
    Recommended name:
    Partitioning defective 6 homolog beta
    Protein Accession:
    Q9BYG5
    Secondary Accessions:
    • A2A2A7
    • Q9Y510

    Protein attributes for PARD6B Gene

    Size:
    372 amino acids
    Molecular mass:
    41182 Da
    Quaternary structure:
    • Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.

    Alternative splice isoforms for PARD6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PARD6B Gene

Post-translational modifications for PARD6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PARD6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for PARD6B
  • Boster Bio Antibodies for PARD6B

No data available for DME Specific Peptides for PARD6B Gene

Domains & Families for PARD6B Gene

Gene Families for PARD6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PARD6B Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
  • Octicosapeptide/Phox/Bem1p
ProtoNet:

Suggested Antigen Peptide Sequences for PARD6B Gene

GenScript: Design optimal peptide antigens:
  • Partitioning defective 6 homolog beta (PAR6B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYG5

UniProtKB/Swiss-Prot:

PAR6B_HUMAN :
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • Belongs to the PAR6 family.
Domain:
  • The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  • The PDZ domain mediates interaction with MPP5.
Family:
  • Belongs to the PAR6 family.
genes like me logo Genes that share domains with PARD6B: view

Function for PARD6B Gene

Molecular function for PARD6B Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Phenotypes From GWAS Catalog for PARD6B Gene

Gene Ontology (GO) - Molecular Function for PARD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA 21873635
GO:0005515 protein binding IPI 11260256
GO:0031267 small GTPase binding IBA --
genes like me logo Genes that share ontologies with PARD6B: view
genes like me logo Genes that share phenotypes with PARD6B: view

miRNA for PARD6B Gene

miRTarBase miRNAs that target PARD6B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARD6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PARD6B Gene

Localization for PARD6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARD6B Gene

Cytoplasm. Cell membrane. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARD6B gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
nucleus 4
cytoskeleton 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PARD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IEA,IDA 12545177
genes like me logo Genes that share ontologies with PARD6B: view

Pathways & Interactions for PARD6B Gene

PathCards logo

SuperPathways for PARD6B Gene

SuperPathway Contained pathways
1 Cell junction organization
2 G-protein signaling RAC1 in cellular process
.37
.37
3 Axon guidance
4 Endocytosis
5 Hippo signaling pathway
genes like me logo Genes that share pathways with PARD6B: view

Pathways by source for PARD6B Gene

3 GeneGo (Thomson Reuters) pathways for PARD6B Gene
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Development A2A receptor signaling
  • G-protein signaling RAC1 in cellular process

Gene Ontology (GO) - Biological Process for PARD6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007043 cell-cell junction assembly TAS 12545177
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IBA 21873635
GO:0007163 establishment or maintenance of cell polarity TAS 14676191
GO:0007409 axonogenesis TAS 14676191
genes like me logo Genes that share ontologies with PARD6B: view

No data available for SIGNOR curated interactions for PARD6B Gene

Drugs & Compounds for PARD6B Gene

(1) Drugs for PARD6B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PARD6B: view

Transcripts for PARD6B Gene

mRNA/cDNA for PARD6B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PARD6B

Alternative Splicing Database (ASD) splice patterns (SP) for PARD6B Gene

No ASD Table

Relevant External Links for PARD6B Gene

GeneLoc Exon Structure for
PARD6B

Expression for PARD6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PARD6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PARD6B Gene

This gene is overexpressed in Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for PARD6B Gene

This gene is overexpressed in Cervix (32.2) and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PARD6B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PARD6B

SOURCE GeneReport for Unigene cluster for PARD6B Gene:

Hs.589848

mRNA Expression by UniProt/SwissProt for PARD6B Gene:

Q9BYG5-PAR6B_HUMAN
Tissue specificity: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

Evidence on tissue expression from TISSUES for PARD6B Gene

  • Kidney(2.5)
genes like me logo Genes that share expression patterns with PARD6B: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARD6B Gene

Orthologs for PARD6B Gene

This gene was present in the common ancestor of animals.

Orthologs for PARD6B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PARD6B 30 31
  • 99.91 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PARD6B 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia PARD6B 31
  • 85 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PARD6B 30 31
  • 81.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pard6b 30 17 31
  • 80.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pard6b 30
  • 79.12 (n)
Chicken
(Gallus gallus)
Aves PARD6B 30 31
  • 77.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PARD6B 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pard6b 30
  • 69.44 (n)
Str.16596 30
African clawed frog
(Xenopus laevis)
Amphibia Par-6 30
Zebrafish
(Danio rerio)
Actinopterygii pard6b 30 31
  • 63.8 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta par-6 31 32
  • 48 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea par-6 31 32
  • 48 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7159 31
  • 40 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11816 30
Species where no ortholog for PARD6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PARD6B Gene

ENSEMBL:
Gene Tree for PARD6B (if available)
TreeFam:
Gene Tree for PARD6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PARD6B: view image

Paralogs for PARD6B Gene

Paralogs for PARD6B Gene

(3) SIMAP similar genes for PARD6B Gene using alignment to 1 proteins:

  • PAR6B_HUMAN

Pseudogenes.org Pseudogenes for PARD6B Gene

genes like me logo Genes that share paralogs with PARD6B: view

Variants for PARD6B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PARD6B Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs61730982 Benign: not provided 50,749,692(+) C/T
NM_032521.3(PARD6B):c.323C>T (p.Thr108Met)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PARD6B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PARD6B Gene

Variant ID Type Subtype PubMed ID
esv3646046 CNV loss 21293372
nsv523874 CNV gain 19592680
nsv834001 CNV loss 17160897

Variation tolerance for PARD6B Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PARD6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARD6B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARD6B Gene

Disorders for PARD6B Gene

Additional Disease Information for PARD6B

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PARD6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARD6B Gene

Publications for PARD6B Gene

  1. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PMID: 11260256) Noda Y … Sumimoto H (Genes to cells : devoted to molecular & cellular mechanisms 2001) 2 3 4
  2. Genome-wide association study on bipolar disorder in the Bulgarian population. (PMID: 21771265) Yosifova A … Nakamura Y (Genes, brain, and behavior 2011) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. (PMID: 15254234) Liu XF … Miki T (Molecular and cellular biology 2004) 3 4
  5. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. (PMID: 12725730) Yamanaka T … Ohno S (Current biology : CB 2003) 3 4

Products for PARD6B Gene

Sources for PARD6B Gene