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This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
PARD3 (Par-3 Family Cell Polarity Regulator) is a Protein Coding gene. Diseases associated with PARD3 include Neural Tube Defects and Gamma Heavy Chain Disease. Among its related pathways are Tight junction and Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is PARD3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 10934474 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISS | -- |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | ISS | -- |
GO:0008289 | lipid binding | IEA | -- |
GO:0019903 | protein phosphatase binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005911 | cell-cell junction | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
3 | Adherens junction | ||
4 | Axon guidance | ||
5 | CCR5 Pathway in Macrophages |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0006612 | protein targeting to membrane | ISS | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0007163 | establishment or maintenance of cell polarity | TAS | 14676191 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | |||||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | - | ||||||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||
SP9: | |||||||||||||||||||||
SP10: | |||||||||||||||||||||
SP11: | |||||||||||||||||||||
SP12: | |||||||||||||||||||||
SP13: | |||||||||||||||||||||
SP14: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PARD3 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | PARD3 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | PARD3 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | PARD3 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PARD3 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Pard3 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pard3 32 |
|
||
chicken (Gallus gallus) |
Aves | PARD3 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | PARD3 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pard3 32 |
|
||
Str.17665 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16888 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | pard3 33 32 |
|
OneToMany | |
CABZ01071446.1 33 |
|
OneToMany | |||
Dr.26612 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | baz 33 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | par-3 33 |
|
OneToMany |
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1114167354 | pathogenic, Neural tube defect, Neural tube defects (NTD) [MIM:182940] | 34,341,696(-) | T/C | coding_sequence_variant, missense_variant | |
rs193920776 | uncertain-significance, Malignant tumor of prostate | 34,470,094(-) | G/A/C | coding_sequence_variant, missense_variant, synonymous_variant | |
rs193920777 | uncertain-significance, Malignant tumor of prostate | 34,470,095(-) | C/A | coding_sequence_variant, missense_variant | |
rs193921017 | uncertain-significance, Malignant tumor of prostate | 34,450,347(-) | C/T | coding_sequence_variant, intron_variant, missense_variant | |
rs199923448 | risk-factor, uncertain-significance, Neural tube defect, not provided, Neural tube defects (NTD) [MIM:182940] | 34,382,893(-) | C/A/T | coding_sequence_variant, missense_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
neural tube defects |
|
|
gamma heavy chain disease |
|
|
anencephaly |
|
|
enamel caries |
|
|
heavy chain disease |
|
|