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Aliases for PAQR9 Gene

Aliases for PAQR9 Gene

  • Progestin And AdipoQ Receptor Family Member 9 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member IX 2 3 4
  • Progesterone And AdipoQ Receptor Family Member 9 3 4
  • Membrane Progesterone P4 Receptor Epsilon 3 4
  • Membrane Progesterone Receptor Epsilon 3 4
  • MPR Epsilon 3 4
  • Membrane Progestin Receptor Epsilon 3

External Ids for PAQR9 Gene

Previous GeneCards Identifiers for PAQR9 Gene

  • GC03M143991
  • GC03M144000
  • GC03M144162
  • GC03M142668
  • GC03M140052

Summaries for PAQR9 Gene

GeneCards Summary for PAQR9 Gene

PAQR9 (Progestin And AdipoQ Receptor Family Member 9) is a Protein Coding gene. An important paralog of this gene is PAQR5.

UniProtKB/Swiss-Prot for PAQR9 Gene

  • Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).

Additional gene information for PAQR9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR9 Gene

Genomics for PAQR9 Gene

GeneHancer (GH) Regulatory Elements for PAQR9 Gene

Promoters and enhancers for PAQR9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J142962 Promoter/Enhancer 1.4 Ensembl ENCODE 650.7 +0.3 335 2.3 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 SP3 ZHX2 PAQR9 U2SURP GC03P142958 PAQR9-AS1
GH03J142997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 -36.7 -36739 6.2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 U2SURP LOC100289361 XRN1 PBX2P1 ATR ST13P15 PAQR9-AS1 PAQR9 TFDP2 LOC100507389
GH03J142940 Enhancer 1 ENCODE 12.9 +22.1 22067 2.9 FOXA2 MLX ARID4B ZNF48 ETS1 YY1 SLC30A9 ATF7 RUNX3 NFKBIZ PCOLCE2 PAQR9 LOC100507389 GC03P142958
GH03J142994 Enhancer 0.8 ENCODE 11.4 -30.5 -30482 0.2 FOXA2 ARID4B ZNF2 RAD21 ARID2 ZNF143 THAP11 MIXL1 DEK ZNF654 PAQR9 PAQR9-AS1 LOC100507389 PLS1 RNA5SP143 LOC100289361 U2SURP GC03M142971
GH03J142988 Enhancer 0.7 Ensembl 11.6 -23.4 -23419 0.2 CTCF ARNT RAD21 CC2D1A ZNF335 ZNF143 SMC3 MIXL1 GATAD2A SMARCA5 LOC100507389 PAQR9 PAQR9-AS1 RNA5SP143 PLS1 LOC100289361 U2SURP GC03M142971
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAQR9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAQR9 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • AREB6
  • Pax-3
  • HNF-4alpha2
  • RORalpha2
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1

Genomic Locations for PAQR9 Gene

Genomic Locations for PAQR9 Gene
chr3:142,949,164-142,963,682
(GRCh38/hg38)
Size:
14,519 bases
Orientation:
Minus strand
chr3:142,668,006-142,682,178
(GRCh37/hg19)
Size:
14,173 bases
Orientation:
Minus strand

Genomic View for PAQR9 Gene

Genes around PAQR9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR9 Gene

Proteins for PAQR9 Gene

  • Protein details for PAQR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVX9-PAQR9_HUMAN
    Recommended name:
    Membrane progestin receptor epsilon
    Protein Accession:
    Q6ZVX9
    Secondary Accessions:
    • Q147T6

    Protein attributes for PAQR9 Gene

    Size:
    377 amino acids
    Molecular mass:
    42692 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

neXtProt entry for PAQR9 Gene

Post-translational modifications for PAQR9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAQR9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PAQR9 Gene

Domains & Families for PAQR9 Gene

Gene Families for PAQR9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PAQR9 Gene

Suggested Antigen Peptide Sequences for PAQR9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVX9

UniProtKB/Swiss-Prot:

PAQR9_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR9: view

Function for PAQR9 Gene

Molecular function for PAQR9 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).

Phenotypes From GWAS Catalog for PAQR9 Gene

Gene Ontology (GO) - Molecular Function for PAQR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
GO:0005496 steroid binding IBA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PAQR9: view
genes like me logo Genes that share phenotypes with PAQR9: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PAQR9 Gene

Localization for PAQR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR9 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PAQR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PAQR9 Gene

Pathways & Interactions for PAQR9 Gene

SuperPathways for PAQR9 Gene

No Data Available

Interacting Proteins for PAQR9 Gene

Gene Ontology (GO) - Biological Process for PAQR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043401 steroid hormone mediated signaling pathway IEA --
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR9: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR9 Gene

Drugs & Compounds for PAQR9 Gene

No Compound Related Data Available

Transcripts for PAQR9 Gene

mRNA/cDNA for PAQR9 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PAQR9 Gene

Progestin and adipoQ receptor family member IX:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR9 Gene

No ASD Table

Relevant External Links for PAQR9 Gene

GeneLoc Exon Structure for
PAQR9
ECgene alternative splicing isoforms for
PAQR9

Expression for PAQR9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAQR9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR9 Gene

This gene is overexpressed in Testis (x15.5), Liver (x12.9), and Heart - Left Ventricle (x7.8).

Protein differential expression in normal tissues from HIPED for PAQR9 Gene

This gene is overexpressed in Pancreatic juice (30.0), Fetal Liver (18.4), Liver (11.5), and Brain (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAQR9 Gene



Protein tissue co-expression partners for PAQR9 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAQR9 Gene:

PAQR9

SOURCE GeneReport for Unigene cluster for PAQR9 Gene:

Hs.408385

mRNA Expression by UniProt/SwissProt for PAQR9 Gene:

Q6ZVX9-PAQR9_HUMAN
Tissue specificity: Expression levels vary widely in a range of tissues (PubMed:16044242). Expressed in the brain, at high level in the pituitary gland and also in hypothalamus, limbic system, caudate nucleus accumens, pons and olfactory bulb (PubMed:23161870).
genes like me logo Genes that share expression patterns with PAQR9: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR9 Gene

Orthologs for PAQR9 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR9 34 33
  • 99.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Paqr9 33
  • 91.64 (n)
dog
(Canis familiaris)
Mammalia PAQR9 34 33
  • 91.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PAQR9 34 33
  • 91.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Paqr9 16 34 33
  • 90.84 (n)
oppossum
(Monodelphis domestica)
Mammalia PAQR9 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAQR9 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858936 33
  • 81.62 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia paqr9 33
  • 69.17 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886606 33
  • 49.68 (n)
PAQR9 34
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 34
  • 22 (a)
OneToMany
Species where no ortholog for PAQR9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAQR9 Gene

ENSEMBL:
Gene Tree for PAQR9 (if available)
TreeFam:
Gene Tree for PAQR9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAQR9: view image

Paralogs for PAQR9 Gene

Paralogs for PAQR9 Gene

genes like me logo Genes that share paralogs with PAQR9: view

Variants for PAQR9 Gene

Sequence variations from dbSNP and Humsavar for PAQR9 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000569541 -- 142,964,025(-) G/T upstream_transcript_variant
rs1000636037 -- 142,963,333(-) G/T coding_sequence_variant, missense_variant
rs1000930479 -- 142,964,412(-) C/G upstream_transcript_variant
rs1001258073 -- 142,964,175(-) G/C upstream_transcript_variant
rs1002108539 -- 142,965,014(-) G/A upstream_transcript_variant

Variation tolerance for PAQR9 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAQR9 Gene

Human Gene Mutation Database (HGMD)
PAQR9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PAQR9 Gene

Disorders for PAQR9 Gene

Additional Disease Information for PAQR9

No disorders were found for PAQR9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR9 Gene

Publications for PAQR9 Gene

  1. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. (PMID: 23161870) Pang Y … Thomas P (Endocrinology 2013) 3 4 58
  2. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. (PMID: 18603275) Smith JL … Lyons TJ (Steroids 2008) 3 22 58
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PAQR9 Gene

Sources for PAQR9 Gene

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