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Aliases for PAQR7 Gene

Aliases for PAQR7 Gene

  • Progestin And AdipoQ Receptor Family Member 7 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member VII 2 3 4
  • Progesterone And AdipoQ Receptor Family Member 7 3 4
  • Membrane Progesterone P4 Receptor Alpha 3 4
  • Membrane Progesterone Receptor Alpha 3 4
  • Membrane Progestin Receptor Alpha 2 3
  • MPR Alpha 3 4
  • 2310021M12Rik 3
  • MPRA 3
  • PGLP 3
  • MRPA 4
  • MSR 3

External Ids for PAQR7 Gene

Previous GeneCards Identifiers for PAQR7 Gene

  • GC01M026060
  • GC01M026187
  • GC01M024443

Summaries for PAQR7 Gene

GeneCards Summary for PAQR7 Gene

PAQR7 (Progestin And AdipoQ Receptor Family Member 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include steroid hormone receptor activity and steroid binding. An important paralog of this gene is PAQR8.

UniProtKB/Swiss-Prot for PAQR7 Gene

  • Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).

Additional gene information for PAQR7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAQR7 Gene

Genomics for PAQR7 Gene

GeneHancer (GH) Regulatory Elements for PAQR7 Gene

Promoters and enhancers for PAQR7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I025995 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.8 -121.2 -121246 4.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 PAFAH2 ARID1A HMGN2 LOC101928324 ENSG00000261349 SYF2 GPN2 ZNF593 LOC101928728 RPL17P9
GH01I025246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +629.7 629653 3.4 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RSRP1 ENSG00000272432 SRRM1 ENSG00000261349 SYF2 ZNF593 STPG1 MAN1C1 PAQR7 ENSG00000284657
GH01I026499 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -624.5 -624474 2.8 CLOCK MLX ZFP64 DMAP1 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZNF610 LOC101928324 ARID1A GPATCH3 DHDDS RPS6KA1 NPM1P39 LOC101928728 PIGV HMGN2 MIR1976
GH01I025831 Enhancer 0.9 ENCODE dbSUPER 12.1 +44.3 44346 2 BCOR PKNOX1 ZMYM3 ZNF121 CTBP1 NCOR1 POLR2A ZSCAN29 FOS ETV6 ENSG00000272478 PIR56916 PIR62460 SELENON PAQR7 ENSG00000207302 EXTL1 SLC30A2 MTFR1L AUNIP
GH01I025888 Enhancer 1.4 Ensembl ENCODE dbSUPER 7.2 -15.9 -15926 8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A IRF4 E2F8 ZNF143 FOS SELENON MTFR1L ARID1A PAFAH2 ENSG00000252190 ENSG00000252691 EXTL1 RNU6-110P SLC30A2 TRIM63
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PAQR7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PAQR7 gene promoter:

Genomic Locations for PAQR7 Gene

Genomic Locations for PAQR7 Gene
chr1:25,861,210-25,876,707
(GRCh38/hg38)
Size:
15,498 bases
Orientation:
Minus strand
chr1:26,187,701-26,197,744
(GRCh37/hg19)

Genomic View for PAQR7 Gene

Genes around PAQR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR7 Gene

Proteins for PAQR7 Gene

  • Protein details for PAQR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK9-PAQR7_HUMAN
    Recommended name:
    Membrane progestin receptor alpha
    Protein Accession:
    Q86WK9
    Secondary Accessions:
    • A2A2D3
    • Q5XKF9
    • Q86VE4

    Protein attributes for PAQR7 Gene

    Size:
    346 amino acids
    Molecular mass:
    39719 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

neXtProt entry for PAQR7 Gene

Post-translational modifications for PAQR7 Gene

Other Protein References for PAQR7 Gene

No data available for DME Specific Peptides for PAQR7 Gene

Domains & Families for PAQR7 Gene

Gene Families for PAQR7 Gene

Protein Domains for PAQR7 Gene

Suggested Antigen Peptide Sequences for PAQR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK9

UniProtKB/Swiss-Prot:

PAQR7_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR7: view

Function for PAQR7 Gene

Molecular function for PAQR7 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).

Phenotypes From GWAS Catalog for PAQR7 Gene

Gene Ontology (GO) - Molecular Function for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IBA --
GO:0005496 steroid binding IBA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PAQR7: view
genes like me logo Genes that share phenotypes with PAQR7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR7 Gene

Localization for PAQR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR7 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR7: view

Pathways & Interactions for PAQR7 Gene

SuperPathways for PAQR7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0043401 steroid hormone mediated signaling pathway IEA --
GO:0048477 oogenesis IEA --
GO:0048545 response to steroid hormone IBA --
genes like me logo Genes that share ontologies with PAQR7: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR7 Gene

Drugs & Compounds for PAQR7 Gene

No Compound Related Data Available

Transcripts for PAQR7 Gene

Unigene Clusters for PAQR7 Gene

Progestin and adipoQ receptor family member VII:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR7 Gene

No ASD Table

Relevant External Links for PAQR7 Gene

GeneLoc Exon Structure for
PAQR7
ECgene alternative splicing isoforms for
PAQR7

Expression for PAQR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PAQR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR7 Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for PAQR7 Gene

This gene is overexpressed in Testis (35.7), Placenta (17.6), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PAQR7 Gene



Protein tissue co-expression partners for PAQR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PAQR7 Gene:

PAQR7

SOURCE GeneReport for Unigene cluster for PAQR7 Gene:

Hs.523652

mRNA Expression by UniProt/SwissProt for PAQR7 Gene:

Q86WK9-PAQR7_HUMAN
Tissue specificity: Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.

Evidence on tissue expression from TISSUES for PAQR7 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with PAQR7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR7 Gene

Orthologs for PAQR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAQR7 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia PAQR7 33 34
  • 89.73 (n)
dog
(Canis familiaris)
Mammalia PAQR7 33
  • 88.95 (n)
rat
(Rattus norvegicus)
Mammalia Paqr7 33
  • 83.87 (n)
mouse
(Mus musculus)
Mammalia Paqr7 33 16 34
  • 83.48 (n)
oppossum
(Monodelphis domestica)
Mammalia PAQR7 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAQR7 33 34
  • 68.44 (n)
lizard
(Anolis carolinensis)
Reptilia PAQR7 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii paqr7b 33 34
  • 60.95 (n)
mpra 33
worm
(Caenorhabditis elegans)
Secernentea K11C4.2 34
  • 25 (a)
OneToMany
Species where no ortholog for PAQR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PAQR7 Gene

ENSEMBL:
Gene Tree for PAQR7 (if available)
TreeFam:
Gene Tree for PAQR7 (if available)

Paralogs for PAQR7 Gene

Paralogs for PAQR7 Gene

(2) SIMAP similar genes for PAQR7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PAQR7: view

Variants for PAQR7 Gene

Sequence variations from dbSNP and Humsavar for PAQR7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000344681 -- 25,869,069(-) G/A intron_variant
rs1000460195 -- 25,864,888(-) G/A intron_variant
rs1000522918 -- 25,876,851(-) GGAAAGGGAAAGGGAAA/GGAAAGGGAAA upstream_transcript_variant
rs1000577264 -- 25,875,586(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000674681 -- 25,870,660(-) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PAQR7 Gene

Variant ID Type Subtype PubMed ID
nsv834502 CNV gain 17160897
nsv834491 CNV loss 17160897
nsv545883 CNV loss 21841781
nsv460884 CNV loss 19166990

Variation tolerance for PAQR7 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAQR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR7 Gene

Disorders for PAQR7 Gene

Additional Disease Information for PAQR7

No disorders were found for PAQR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PAQR7 Gene

Publications for PAQR7 Gene

  1. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. (PMID: 19071147) Thomas P … Garry VF (Steroids 2009) 3 22 58
  2. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. (PMID: 17082257) Thomas P … Tubbs C (Endocrinology 2007) 3 22 58
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The further redefining of steroid-mediated signaling. (PMID: 12606724) Hammes SR (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for PAQR7 Gene

Sources for PAQR7 Gene

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