Aliases for PAQR5 Gene

Aliases for PAQR5 Gene

  • Progestin And AdipoQ Receptor Family Member 5 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member V 2 3 4
  • Membrane Progestin Receptor Gamma 2 3 4
  • MPRG 2 3 4
  • Progesterone And AdipoQ Receptor Family Member 5 3 4
  • Membrane Progesterone P4 Receptor Gamma 3 4
  • Membrane Progesterone Receptor Gamma 3 4
  • MPR Gamma 3 4
  • FLJ20190 2
  • PAQR5 5

External Ids for PAQR5 Gene

Previous GeneCards Identifiers for PAQR5 Gene

  • GC15P067379
  • GC15P069591
  • GC15P046424
  • GC15P069298

Summaries for PAQR5 Gene

GeneCards Summary for PAQR5 Gene

PAQR5 (Progestin And AdipoQ Receptor Family Member 5) is a Protein Coding gene. Diseases associated with PAQR5 include Amusia. Gene Ontology (GO) annotations related to this gene include steroid binding. An important paralog of this gene is PAQR8.

UniProtKB/Swiss-Prot Summary for PAQR5 Gene

  • Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAQR5 Gene

Genomics for PAQR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PAQR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J069298 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 615.2 +15.9 15867 3.2 ZNF692 ZNF174 PRDM1 ZIC2 ZSCAN4 PATZ1 EZH2 ZNF341 ZNF561 ZBTB44 PAQR5 ENSG00000261634 LOC102723548 KIF23 ANP32A ENSG00000259504 SNORA77-001
GH15J069303 Enhancer 1 ENCODE dbSUPER 15.9 +20.7 20692 3.5 GATAD2A CTCF TEAD4 JUND PKNOX1 RXRB NR2C1 REST GABPA CEBPA PAQR5 LOC102723548 SNORA77-001 KIF23
GH15J069412 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7.1 +130.3 130267 4.8 SP1 CREB1 PRDM10 ZNF629 RFX1 ZNF692 POLR2A TARDBP ZHX2 JUND LOC145694 KIF23 PAQR5 RPLP1
GH15J069342 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 17 +59.5 59497 2.7 PRDM10 ZNF512 ZNF366 PRDM6 ZNF521 GLIS1 PAQR5 SNORA77-001 piR-56133-073 KIF23
GH15J069357 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 10.8 +75.8 75767 4.2 GATAD2A SCRT2 ESR1 NFE2 ZNF316 ZSCAN5C MAFG NFIC STAT1 NR2F1 piR-56133-073 PAQR5 RF00017-1826 KIF23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAQR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAQR5

Top Transcription factor binding sites by QIAGEN in the PAQR5 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Ik-1
  • SRF
  • SRF (504 AA)

Genomic Locations for PAQR5 Gene

Genomic Locations for PAQR5 Gene
chr15:69,284,134-69,407,780
(GRCh38/hg38)
Size:
123,647 bases
Orientation:
Plus strand
chr15:69,591,286-69,700,119
(GRCh37/hg19)
Size:
108,834 bases
Orientation:
Plus strand

Genomic View for PAQR5 Gene

Genes around PAQR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR5 Gene

Proteins for PAQR5 Gene

  • Protein details for PAQR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXK6-PAQR5_HUMAN
    Recommended name:
    Membrane progestin receptor gamma
    Protein Accession:
    Q9NXK6
    Secondary Accessions:
    • Q8IXU2

    Protein attributes for PAQR5 Gene

    Size:
    330 amino acids
    Molecular mass:
    38014 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

neXtProt entry for PAQR5 Gene

Post-translational modifications for PAQR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PAQR5
  • Boster Bio Antibodies for PAQR5

No data available for DME Specific Peptides for PAQR5 Gene

Domains & Families for PAQR5 Gene

Gene Families for PAQR5 Gene

Protein Domains for PAQR5 Gene

InterPro:
Blocks:
  • Hly-III related proteins
ProtoNet:

Suggested Antigen Peptide Sequences for PAQR5 Gene

GenScript: Design optimal peptide antigens:
  • Progestin and adipoQ receptor family member V (MPRG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXK6

UniProtKB/Swiss-Prot:

PAQR5_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR5: view

Function for PAQR5 Gene

Molecular function for PAQR5 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).

Phenotypes From GWAS Catalog for PAQR5 Gene

Gene Ontology (GO) - Molecular Function for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with PAQR5: view
genes like me logo Genes that share phenotypes with PAQR5: view

Animal Model Products

CRISPR Products

miRNA for PAQR5 Gene

miRTarBase miRNAs that target PAQR5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR5 Gene

Localization for PAQR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
mitochondrion 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR5: view

Pathways & Interactions for PAQR5 Gene

PathCards logo

SuperPathways for PAQR5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0048477 oogenesis IEA --
genes like me logo Genes that share ontologies with PAQR5: view

No data available for Pathways by source and SIGNOR curated interactions for PAQR5 Gene

Drugs & Compounds for PAQR5 Gene

No Compound Related Data Available

Transcripts for PAQR5 Gene

mRNA/cDNA for PAQR5 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR5

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for PAQR5 Gene

GeneLoc Exon Structure for
PAQR5

Expression for PAQR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAQR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PAQR5 Gene

This gene is overexpressed in Kidney - Cortex (x10.0), Adrenal Gland (x6.5), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for PAQR5 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PAQR5 Gene



Protein tissue co-expression partners for PAQR5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAQR5

SOURCE GeneReport for Unigene cluster for PAQR5 Gene:

Hs.591096

mRNA Expression by UniProt/SwissProt for PAQR5 Gene:

Q9NXK6-PAQR5_HUMAN
Tissue specificity: Expressed in the brain, lung, kidney, colon, adrenal and lung.

Evidence on tissue expression from TISSUES for PAQR5 Gene

  • Kidney(4.4)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with PAQR5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR5 Gene

Orthologs for PAQR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAQR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PAQR5 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PAQR5 30 31
  • 89.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Paqr5 30 17 31
  • 88.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Paqr5 30
  • 88.28 (n)
Cow
(Bos Taurus)
Mammalia PAQR5 30 31
  • 86.16 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PAQR5 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PAQR5 31
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PAQR5 30 31
  • 66.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PAQR5 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia paqr5 30
  • 62.8 (n)
Zebrafish
(Danio rerio)
Actinopterygii paqr5b 30 31
  • 63.37 (n)
OneToMany
paqr5a 31
  • 50 (a)
OneToMany
zgc56016 30
Worm
(Caenorhabditis elegans)
Secernentea K11C4.2 31
  • 22 (a)
OneToMany
Species where no ortholog for PAQR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PAQR5 Gene

ENSEMBL:
Gene Tree for PAQR5 (if available)
TreeFam:
Gene Tree for PAQR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAQR5: view image

Paralogs for PAQR5 Gene

Paralogs for PAQR5 Gene

(2) SIMAP similar genes for PAQR5 Gene using alignment to 3 proteins:

  • MPRG_HUMAN
  • H0YL06_HUMAN
  • L8E9R0_HUMAN
genes like me logo Genes that share paralogs with PAQR5: view

Variants for PAQR5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAQR5 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs17853893 - p.Ile24Thr

Additional dbSNP identifiers (rs#s) for PAQR5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PAQR5 Gene

Variant ID Type Subtype PubMed ID
dgv1438e59 CNV duplication 20981092
esv1010893 CNV deletion 20482838
esv1243241 CNV deletion 17803354
esv2092169 CNV deletion 18987734
esv2343800 CNV deletion 18987734
esv2659982 CNV deletion 23128226
esv2663165 CNV deletion 23128226
esv2675617 CNV deletion 23128226
esv2749825 CNV deletion 23290073
esv2749826 CNV deletion 23290073
esv2749827 CNV deletion 23290073
esv2749828 CNV deletion 23290073
esv2749829 CNV deletion 23290073
esv2749831 CNV deletion 23290073
esv2749832 CNV deletion 23290073
esv2760037 CNV loss 17122850
esv3552626 CNV deletion 23714750
esv3636823 CNV loss 21293372
esv3636824 CNV loss 21293372
esv5119 CNV loss 18987735
nsv1044617 CNV gain 25217958
nsv1151771 CNV deletion 26484159
nsv1151947 CNV deletion 26484159
nsv512401 CNV loss 21212237
nsv827379 CNV loss 20364138
nsv94997 CNV deletion 16902084
nsv951985 CNV deletion 24416366
nsv958022 CNV deletion 24416366

Variation tolerance for PAQR5 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAQR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAQR5 Gene

Disorders for PAQR5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAQR5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amusia
  • receptive amusia
- elite association - COSMIC cancer census association via MalaCards
Search PAQR5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PAQR5

genes like me logo Genes that share disorders with PAQR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAQR5 Gene

Publications for PAQR5 Gene

  1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 3 41
  2. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 3 4
  3. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. (PMID: 12601167) Zhu Y … Thomas P (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  4. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. (PMID: 12574519) Zhu Y … Thomas P (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PAQR5 Gene

Sources for PAQR5 Gene