Aliases for PAQR4 Gene

Aliases for PAQR4 Gene

  • Progestin And AdipoQ Receptor Family Member 4 2 3 4 5
  • Progestin And AdipoQ Receptor Family Member IV 2 3 4
  • FLJ30002 2
  • PAQR4 5

External Ids for PAQR4 Gene

Previous GeneCards Identifiers for PAQR4 Gene

  • GC16P003004
  • GC16P002959
  • GC16P003020
  • GC16P003021
  • GC16P002992

Summaries for PAQR4 Gene

GeneCards Summary for PAQR4 Gene

PAQR4 (Progestin And AdipoQ Receptor Family Member 4) is a Protein Coding gene. Diseases associated with PAQR4 include Isolated Growth Hormone Deficiency, Type Ib. An important paralog of this gene is ADIPOR1.

Additional gene information for PAQR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PAQR4 Gene

Genomics for PAQR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PAQR4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PAQR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PAQR4

Top Transcription factor binding sites by QIAGEN in the PAQR4 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NRSF form 1
  • NRSF form 2

Genomic Locations for PAQR4 Gene

Genomic Locations for PAQR4 Gene
chr16:2,969,270-2,973,484
(GRCh38/hg38)
Size:
4,215 bases
Orientation:
Plus strand
chr16:3,019,246-3,023,490
(GRCh37/hg19)
Size:
4,245 bases
Orientation:
Plus strand

Genomic View for PAQR4 Gene

Genes around PAQR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAQR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAQR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAQR4 Gene

Proteins for PAQR4 Gene

  • Protein details for PAQR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4S7-PAQR4_HUMAN
    Recommended name:
    Progestin and adipoQ receptor family member 4
    Protein Accession:
    Q8N4S7
    Secondary Accessions:
    • A8K5Q8
    • D3DUA2
    • D3DUA3
    • Q8NAS6
    • Q96NW1

    Protein attributes for PAQR4 Gene

    Size:
    273 amino acids
    Molecular mass:
    29126 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PAQR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAQR4 Gene

Post-translational modifications for PAQR4 Gene

  • Ubiquitination at Lys23
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PAQR4 Gene

Domains & Families for PAQR4 Gene

Gene Families for PAQR4 Gene

Protein Domains for PAQR4 Gene

InterPro:
Blocks:
  • Hly-III related proteins
ProtoNet:

Suggested Antigen Peptide Sequences for PAQR4 Gene

GenScript: Design optimal peptide antigens:
  • Progestin and adipoQ receptor family member IV (PAQR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4S7

UniProtKB/Swiss-Prot:

PAQR4_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with PAQR4: view

Function for PAQR4 Gene

Phenotypes From GWAS Catalog for PAQR4 Gene

Gene Ontology (GO) - Molecular Function for PAQR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with PAQR4: view
genes like me logo Genes that share phenotypes with PAQR4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAQR4 Gene

Localization for PAQR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAQR4 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PAQR4 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
nucleus 1
extracellular 0
cytoskeleton 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PAQR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PAQR4: view

Pathways & Interactions for PAQR4 Gene

PathCards logo

SuperPathways for PAQR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAQR4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAQR4 Gene

Drugs & Compounds for PAQR4 Gene

No Compound Related Data Available

Transcripts for PAQR4 Gene

mRNA/cDNA for PAQR4 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PAQR4

Alternative Splicing Database (ASD) splice patterns (SP) for PAQR4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for PAQR4 Gene

GeneLoc Exon Structure for
PAQR4

Expression for PAQR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PAQR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for PAQR4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8) and Brain - Substantia nigra (x4.1).

Protein differential expression in normal tissues from HIPED for PAQR4 Gene

This gene is overexpressed in Retina (54.6) and Spinal cord (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PAQR4 Gene



Protein tissue co-expression partners for PAQR4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PAQR4

SOURCE GeneReport for Unigene cluster for PAQR4 Gene:

Hs.351474

mRNA Expression by UniProt/SwissProt for PAQR4 Gene:

Q8N4S7-PAQR4_HUMAN
Tissue specificity: Relatively widely expressed in a range of tissues.

Evidence on tissue expression from TISSUES for PAQR4 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PAQR4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PAQR4 Gene

Orthologs for PAQR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAQR4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PAQR4 30 31
  • 99.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PAQR4 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PAQR4 31
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PAQR4 30 31
  • 90.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PAQR4 30 31
  • 90.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Paqr4 30
  • 89.26 (n)
Mouse
(Mus musculus)
Mammalia Paqr4 30 17 31
  • 88.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PAQR4 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia paqr4 30
  • 64.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia krm2 30
Zebrafish
(Danio rerio)
Actinopterygii LOC568196 30
  • 62.99 (n)
PAQR4 (2 of 2) 31
  • 62 (a)
OneToMany
PAQR4 (1 of 2) 31
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000844 30
  • 50 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG33203 30 31
  • 49.68 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH2 31
  • 20 (a)
ManyToMany
IZH1 31
  • 19 (a)
ManyToMany
Species where no ortholog for PAQR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PAQR4 Gene

ENSEMBL:
Gene Tree for PAQR4 (if available)
TreeFam:
Gene Tree for PAQR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PAQR4: view image

Paralogs for PAQR4 Gene

Paralogs for PAQR4 Gene

genes like me logo Genes that share paralogs with PAQR4: view

Variants for PAQR4 Gene

Additional dbSNP identifiers (rs#s) for PAQR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PAQR4 Gene

Variant ID Type Subtype PubMed ID
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv571246 CNV loss 21841781
nsv827525 CNV gain 20364138
nsv952906 CNV deletion 24416366

Variation tolerance for PAQR4 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PAQR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PAQR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PAQR4 Gene

Disorders for PAQR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PAQR4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
isolated growth hormone deficiency, type ib
  • pituitary dwarfism i
- elite association - COSMIC cancer census association via MalaCards
Search PAQR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PAQR4

genes like me logo Genes that share disorders with PAQR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAQR4 Gene

Publications for PAQR4 Gene

  1. The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis. (PMID: 28992327) Wang L … Chen Y (Journal of molecular cell biology 2017) 2 3
  2. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PMID: 20694148) Zabaneh D … Balding DJ (PloS one 2010) 3 41
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PAQR4 Gene

Sources for PAQR4 Gene